Trypanosoma congolense
Detection of multiple drug resistant Trypanosoma congolense populations in village cattle of south east Mali
... In the present study, an abbreviated 28-day field protocol based on treatment of naturally infected cattle [9] was preferred over the longer follow-up protocol [17]. Although there was risk of underestimating the re- ...
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Antitrypanosomal activity of Verbascum sinaiticum Benth (Scrophulariaceae) against Trypanosoma congolense isolates
... The trypanocidal and trypanostatic efficacy of V. sinaiti- cum aqueous and methanol extracts are associated with the presence of one or more biological active principals. This was shown to be true by the positive test ...
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Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection
... a major constraint on cattle productivity in sub-Saharan Africa. Some African Bos taurus breeds are highly tolerant of infection, but the potentially more productive Bos indicus zebu breeds are much more susceptible. ...
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Molecular and Biochemical Characterization of a Cathepsin B-Like Protease Family Unique to Trypanosoma congolense
... Cysteine proteases have been shown to be essential virulence factors and drug targets in trypanosomatids and an attractive antidisease vaccine candidate for Trypanosoma congolense. Here, we describe an ...
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Effects of experimental Trypanosoma congolense infection on sperm morphology in Yankasa rams
... Trypanosoma congolense through the jugular vein. All the rams were closely monitored for clinical signs suggestive of trypanosomosis. Semen was collected weekly from each ram, for seven weeks using ...
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Trypanocidal activity of ethanolic extracts of Commiphora swynnertonii Burtt on Trypanosoma congolense
... Plant extracts have been found to have antitrypanoso- mal activity against trypanosomes in different plant ex- tracts evaluated in vitro [20]. Considering the previous reports on C. swynnertonii extracts activity, there ...
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Cloning and Expression of Mitochondrial Heat Shock Protein 70 of Trypanosoma congolense and Potential Use as a Diagnostic Antigen
... The ability to use mitochondrial heat shock protein 70 (MTP) of Trypanosoma congolense as a diagnostic antigen was examined. One cDNA clone was obtained by immunoscreening of a T. congolense ...
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Symptoms and Response to Treatment with Diminazene Aceturate and Mebendazole in Dogs Infected with Single Trypanosoma congolense, Ancylostoma caninum and Combination of Trypanosoma congolense and Ancylostoma caninum
... Trypanosoma congolense is the major species of trypanosome responsible for the disease “Nagana” in livestocks ...T. congolense and in combination with ...
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In vivo effect of Commiphora swynnertonii ethanolic extracts on Trypanosoma congolense and selected immunological components in mice
... In vivo activity of the extract on Trypanosoma congolense A sum of 40 clinically health mice were inoculated intra- peritoneally with approximately 3 × 10 5 trypanosomes. The mice had parasitaemia of ...
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Population genetics of forest type of Trypanosoma congolense circulating in Glossina palpalis palpalis of Fontem in the South West region of Cameroon
... T. congolense forest has a higher infectious rate than ...T. congolense savannah. The low infection of T. congolense savannah is probably due to the level of pathogenicity of this trypanosome ...T. ...
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Trypanosoma congolense Procyclins: Unmasking Cryptic Major Surface Glycoproteins in Procyclic Forms
... SDS-PAGE and immunoblotting. SDS-polyacrylamide gel electrophoresis (SDS-PAGE) was performed under reducing conditions (26) on 12% polyacryl- amide gels. For fluorography, gels were soaked in Amplify (Amersham), dried, ...
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In Vivo anti trypanosomal activity of dichloromethane and methanol crude leaf extracts of Dovyalis abyssinica (Salicaceae) against Trypanosoma congolense
... On the other hand, only MOH-250 mg/kg and MOH-200 mg/kg were shown to significantly reduce parasitemia level from D14 to D20 compared to the lowest two doses (150 and 100 mg/kg) and DMSO- treated groups. Within this ...
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A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice
... T. congolense infection was selected in the 1990’s because the large variance between strains made it more likely that there would be QTL of large enough effect to be ...
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Haemoassessment of Dogs Experimentally Infected with Single and Conjunct Trypanosoma congolense and Ancylostoma caninum and Treatment with Diminazene Aceturate and Mebendazole
... Dogs were randomly divided into 3 groups of 4 members in each group. GROUP I was uninfected dogs (control), GROUP II was infected with T. congolense, and GROUP III was mixed infections of T. congolense and ...
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Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data with a set of universal protein motifs
... (SNP), estimated with RAxML (Stamatakis 2014) with a GTR+ Γ model and 100 bootstrap replicates (branches with bootstrap >70 are shown in bold). Labels ‘i’ to ‘v’ denote examples referred to in the text. Label ‘i’ ...
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Expression profiling of Trypanosoma congolense genes during development in the tsetse fly vector Glossina morsitans morsitans
... T. congolense 45 ...T. congolense ACs in the cardia may be linked to increased function of cAMP mediated signal- ing pathways and social motility [69], as C-parasites do not divide ...T. congolense ...
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Evidence for viable and stable triploid Trypanosoma congolense parasites
... Our finding is a recent addition to increasing observa- tions of changes in ploidy found in trypanosomatid para- sites such as clinical and laboratory lines of Leishmania spp. [17, 21, 28, 29] and T. cruzi parasites [22, ...
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Characterization of an epimastigote stage specific hemoglobin receptor of Trypanosoma congolense
... heme synthesis [21]. As seen in Trypanosoma and Leishmania, heme uptake is important for the growth and development of the parasite [6, 22]. For example, TbHpHbR knockout mutants caused a de- crease in the growth ...
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Equine trypanosomosis: enigmas and diagnostic challenges
... genus Trypanosoma that are transmitted cyclically by tsetse flies, mechanically by other haematopha- gous flies, or ...sexually. Trypanosoma congolense (subgenus Nannomonas) and ...
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A comparative evaluation of PCR based methods for species specific determination of African animal trypanosomes in Ugandan cattle
... for Trypanosoma congolense, Trypanosoma brucei and Trypanosoma vivax and compared to a modified (using eluate extracted using chelex) ITS-PCR ...
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