Trypanosoma cruzi I
Towards a New Strategy for Diagnosis of Congenital Trypanosoma cruzi Infection
... congenital Trypanosoma cruzi infection, (ii) assess the utility of these techniques for diagnosing a congenital transmission, and (iii) propose a strategy for a prompt, effi- cient, and cost-effective ...
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Oxidative stress fuels Trypanosoma cruzi infection in mice
... studied Trypanosoma cruzi infection in mice in which NRF2/HO-1 was induced with cobalt protoporphyrin ...T. cruzi parasitemia in ...type I IFN, or ...
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Multilocus sequence typing: genetic diversity in Trypanosoma cruzi I (TcI) isolates from Brazilian didelphids
... Trypanosoma cruzi is a minimally diploid organism and as such heterozygosity renders MLST analysis more difficult than in haploid organisms. As mentioned above, heterozygosity was inferred from ...
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A reduction in ecological niche for Trypanosoma cruzi infected triatomine bugs
... of Trypanosoma cruzi, the causal agent of Chagas ...control. Trypanosoma cruzi is a typical parasite with a complex life-cycle; it requires bugs to carry and transfer it to humans and other ...
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Trypanosoma cruzi infection associated with atypical clinical manifestation during the acute phase of the Chagas disease
... T. cruzi was performed using the primers TCZ_F (5ʹ-GCT CTT GCC CAC AMG GGT GC-3ʹ) and TCZ_R (5ʹ-CCA AGC AGC GGA TAG TTC AGG-3ʹ), which amplify a region of 188 bp; the satellite DNA PCR conditions were set ...
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Role of iron in Trypanosoma cruzi infection of mice
... T. cruzi with the peak hypoferremia also occurring 28 d after inoculation of the ...T. cruzi was shown to require both a heme and a nonheme iron source for an optimal growth ...T. cruzi correlated ...
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Wild Trypanosoma cruzi I genetic diversity in Brazil suggests admixture and disturbance in parasite populations from the Atlantic Forest region
... implemented in PhyML (4 substitution rate categories) [36]. The best-fit model of nucleotide substitution was se- lected from 88 models and its significance evaluated ac- cording to the Akaike Information Criterion (AIC) ...
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Untangling the transmission dynamics of primary and secondary vectors of Trypanosoma cruzi in Colombia: parasite infection, feeding sources and discrete typing units
... and the Colombian Caribbean region [40, 46, 48, 49]. We detected five DTUs in this species (TcI-TcV) that is in ac- cordance with previous reports in Brazil, Venezuela and the Colombian Orinoco, and showing the ...
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Bioluminescent imaging of Trypanosoma cruzi infection in Rhodnius prolixus
... weighed 35.2 ± 3.4 mg, were randomly chosen and then allowed to feed on defibrinated rabbit blood through a membrane feeding apparatus [4]. Defibrinated rabbit blood used for feeding the insects was provided by the ...
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Different serological cross reactivity of Trypanosoma rangeli forms in Trypanosoma cruzi infected patients sera
... of Trypanosoma cruzi (Y strain) and Trypanosoma rangeli (Choachi strain) with chagasic ...T. cruzi (dark arrows) or on ...T. cruzi-infected patients. Lanes 1 and 2 = T. cruzi Y ...
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PCR Assay for Monitoring Trypanosoma cruzi Parasitemia in Childhood after Specific Chemotherapy
... of Trypanosoma cruzi infection by antibody seroconversion usually involves several years of ...T. cruzi-seropositive children, who were enrolled in a field trial of benznidazole (Bz) ...T. ...
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Design, structure–activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi
... parasite Trypanosoma cruzi, is a major neglected parasitic disease endemic in South and Central America with an increasing number of cases reported in countries such as USA, Spain and ...T. cruzi ...
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1 The Janus Face of NKT Cell Function in
... anti-inflammatory functions of different subsets of CD1d-restricted natural killer T cells during 369. Trypanosoma cruzi infection[r] ...
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Pathogen Species Identification from Metagenomes in Ancient Remains: the Challenge of Identifying Human Pathogenic Species of Trypanosomatidae Via Bioinformatic Tools
... confirmed Trypanosoma cruzi infection and undoubtedly Leishmania infection in the three Andean ...T. cruzi, in all mummies with available ...T. cruzi belonging to some ...
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Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast myofibroblast transition and increase in expression of extracellular matrix proteins
... T. cruzi infection led to a transi- ent increase in expression of SMA, thus indicating fibroblast-to-myofibroblast ...T. cruzi induce the activation of TGF-beta [30] and pro-fibrotic proteins [31] as well ...
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Journal of Applied Pharmaceutical Science
... The Y strain of T. cruzi was used in the assays. This strain is characterized by thin forms and tropism for phagocytic mononuclear cells (Pereira da Silva and Nussenzweig, 1953). The Y strain of T. cruzi is ...
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Mitochondrial dysfunction in Trypanosoma cruzi: the role of Serratia marcescens prodigiosin in the alternative treatment of Chagas disease
... complex I and IV, respectively, do not have an effect on T. cruzi viability, and caused slight or no Ψm and cellular respiration ...T. cruzi complex I is absent or at least can- not be ...
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Trypanosoma dionisii as an experimental model to study anti-Trypanosoma cruzi drugs: A comparative analysis with benznidazole, posaconazole and amiodarone
... T. cruzi, using amiodarone or posaconazole, we note that there is a reduction of about 10 ...cholesterol. Trypanosoma cruzi depends on de-novo ergosterol production for its survival in all the stages ...
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Detection of Trypanosoma cruzi and Trypanosoma rangeli Infection by Duplex PCR Assay Based on Telomeric Sequences
... Trypanosoma cruzi causes Chagas’ disease, a fatal illness endemic to many Latin American ...T. cruzi shares reservoirs and vectors with the related protozoan Trypanosoma rangeli, which is ...
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CRISPR Cas9 Mediated Single Gene and Gene Family Disruption in Trypanosoma cruzi
... T. cruzi, demonstrating rapid and efficient knockout of multiple endogenous genes, including essential ...T. cruzi occurs exclusively by microhomology-mediated end joining (MMEJ) with various-sized ...T. ...
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