TS, thymidylate synthase
Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC
... and thymidylate synthase (TS); but is most potent on TS ...of TS mRNA and TS protein differed between squamous cell lung cancer or NSCLC and lung adenocar- cinoma ...that ...
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Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase thymidylate synthase
... reductase-thymidylate synthase (pfDHFR-TS) is a well-defined target of antifolate drugs such as pyrimethamine and ...as thymidylate (dTMP) required for DNA synthesis ...
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Efficient Generation of Power In Medium Voltage Direct Current Systems: Variable Speed Operation and Rectifier Considerations
... of thymidylate synthase (TS) (Berger and Berger, 2006; Wyatt and Wilson, ...response. TS inhibition is known as a major mechanism of 5-FU cytotoxicity; the degree of its inhibition could ...
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Organization of the thymidylate synthase gene of herpesvirus saimiri.
... pseudorabies virus 69% 19, and human cytomegalovirus 56% 13, did not induce TS activity in permissive cells during virus replication 22, and no nucleotide or amino acid sequence homology[r] ...
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trans activation of the thymidylate synthase promoter of herpesvirus saimiri.
... Here we describe the regulation of the herpesvirus saimiri TS gene that is increasingly expressed from delayed-early to late times of virus infection and identify a genomic upstream regi[r] ...
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Original Article Correlations between expression levels of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase, and efficacy of 5-fluorouracil-based chemotherapy for advanced colorectal cancer
... enzymes, thymidylate synthase (TS), thymidine phosphorylase (TP), and dihydropyrimidine de- hydrogenase (DPD) are known to play important roles in the efficacy of therapeutic ...of TS, TP, and ...
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siRNA Targeting of Thymidylate Synthase, Thymidine Kinase 1 and Thymidine Kinase 2 as an Anticancer Therapy: A Combinatorial RNAi Approach
... of TS than normal, non-tumour proliferating cells [180, 182]. TS enzyme levels are tightly regulated at the level of ...The TS protein can bind to its own mRNA to inhibit translational processing of ...
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Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients
... the TS-negative patients (P= ...between TS expression and OS was found in ADC (P= ...the TS-negative group had higher risk of death, in the whole group and in subgroups, such as ADC, patients ,60 ...
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Pharmacogenetic Analysis of the UK MRC (Medical Research Council) MAGIC Trial: Association of Polymorphisms with Toxicity and Survival in Patients Treated with Perioperative Epirubicin, Cisplatin, and 5-fluorouracil (ECF) Chemotherapy.
... in thymidylate synthase (TS), a 2R/2R tandem repeat, was significantly associated with overall survival in patients treated with chemotherapy, but not in patients treated with surgery ...
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5-Fluorouracil targets thymidylate synthase in the selective suppression of T 17 cell differentiation
... 5-FU, an analogue of uracil, is commonly used as a chemotherapeutic drug for treating various kinds of tumors, primarily through inhibition of TS [26-29]. Due to its structural similarity to uracil, 5-FU and its ...
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Association of thymidylate synthase expression and clinical outcomes of gastric cancer patients treated with fluoropyrimidine-based chemotherapy: a meta-analysis
... demonstrated that omission of any single study would not alter the impact of the final result. And subgroup analysis stratified by study region has minimized the intergroup het- erogeneity (Figure 3), which displayed a ...
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Clinical significance of the thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase mRNA expressions in hepatocellular carcinoma patients receiving 5-fluorouracil-based transarterial chemoembolization treatment
... of TS, TP, DPD, and the internal control of β -actin were quantified using the MX3000P (Stratgene, La Jolla, CA, USA) with 25 µ L polymerase chain reaction (PCR) reaction system con- taining 10 µ m for each ...
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Thymidylate synthase polymorphisms in genomic DNA as clinical outcome predictors in a European population of advanced non small cell lung cancer patients receiving pemetrexed
... A recent study by Hu et al. [21] investigated the differ- ent TS polymorphisms in genomic DNA of 90 Asian NSCLC patients. In contrast with our findings, no spe- cific genotype regarding the TSER or 3′-UTR polymor- ...
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Wide-Scale Use of Notch Signaling Factor CSL/RBP-Jκ in RTA-Mediated Activation of Kaposi's Sarcoma-Associated Herpesvirus Lytic Genes
... Identification of three new RTA-responsive promoters. In view of the large number of potential CSL sites, we selected four clusters (M type) (Fig. 1B to D) for further testing; spe- cifically, we chose the clusters ...
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Thymidylate synthase gene (TYMS) polymorphisms in sporadic and hereditary breast cancer
... the Thymidylate synthase gene (TYMS), located at band ...[9]. Thymidylate synthase is a key enzyme in the folate metabolism originating from the diet, catalyzing the deoxyuridine monophosphate ...
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Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase
... Notes: Panc-1 cells were treated with various concentrations of ribonucleotide reductase inhibitors, (A, B) cladribine, (C, D) gemcitabine, (E, F) hydroxyurea and thymidine synthase inhibitors, (G, H) ...
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<p>Proteomics of Sentinel Lymph Nodes in Early Breast Cancer for Identification of Thymidylate Synthase as a Potential Biomarker to Flag Metastasis: A Preliminary Study</p>
... anti-thymidylate synthase antibody (Elabsciences; 1:10,000) and anti- β -actin antibody (Elabsciences; 1:10,000), at 4 °C ...the thymidylate synthase and β -actin bands intensity in blot ...
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Index Catalog // Carolina Digital Repository
... DPD is responsible for the first and rate-limiting step of 5-FU catabolism and mediates over 80% of 5-FU elimination. Therefore, higher levels of DPD, as seen in the exposed samples, would be expected to be associated ...
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MOLECULAR MARKERS FOR CAPECITABINE THERAPY: A REVIEW
... of TS and TP was associated with a higher RR than was low expression of TS and TP ...with TS expression (P = ...the TS and ERCC1 genotypes on XELOX efficacy compared with the outcome of an ...
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Relating protein pharmacology by ligand chemistry.pdf
... The similarity of the ligand sets to only a few others owes to the intrinsic chemical differences between most sets and to the statistical model’s discrimination between significant (e.g., E-value < 1 × 10 −10 ) and ...
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