TTF-1.
Original Article Associations of deregulation of mir-365 and its target mRNA TTF-1 and survival in patients with NSCLC
... while TTF-1 was increased, it was showed that mir- 365 expression could downregulate TTF-1 [13, ...factor 1 (TTF-1), encoded by NKX2 homeobox 1 (NKX2-1) gene ...
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Value of thyroid transcription factor (TTF)-1 for diagnosis and prognosis of patients with locally advanced or metastatic small cell lung cancer
... The TTF-1 immunostaining was prospectively ...with TTF-1-positive SCLC had a median OS of 374 (95% CI 306 – 442) ...with TTF-1-expression (DCR 86% ...
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Correlation of TTF-1 and Napsin A expression in CT-guided percutaneous puncture tissue with the malignant biology of cancer cells
... Lung cancer is one of the most common malignant tumors worldwide, the incidence is increasing year by year and it trends to occur in the younger. CT-guided percutaneous puncture lung tissue biopsy is the effective means ...
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Original Article TTF-1 and EGFR expression are related to EGFR mutation in lung adenocarcinoma
... In the past decade, major progress has been made toward personalized medical treatment of NSCLC through the discovery of EGFR muta- tions. EGFR TKIs are shown to be superior to chemotherapy in first-line therapy of ...
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Case Report Primary pleomorphic adenoma of the lung with positive staining of TTF-1: a case report and review of literature
... Abstract: Pleomorphic adenoma is a common tumor occurring in the salivary glands of head and neck. But, it is extremely rare in the trachea or lung. Here, we reported a case of primary pleomorphic adenoma of the lung. A ...
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TTF-1 regulates α5 nicotinic acetylcholine receptor (nAChR) subunits in proximal and distal lung epithelium
... [29]. TTF-1 regulates cytodifferentiation and for- mation of functional respiratory epithelium ...of TTF-1, also individually and synergistically activate the a 5 promoter, suggesting complex ...
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Case Report KRAS mutation-positive bronchial surface epithelium (BSE)-type lung adenocarcinoma with strong expression of TTF-1: a case providing a further insight as for the role of TTF-1 in the oncogenesis
... was TTF-1 posi- ...and TTF-1 expression and EGFR mutation, Sumiyoshi et ...on TTF-1, MUC5B/5AC, and other immunohistochemical findings and driver gene mutation patterns [3]: ...
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Congenital human thyroglobulin defect due to low expression of the thyroid specific transcription factor TTF 1
... However, TTF-1 and Pax-8 preferentially bind to the thyroglobulin and thyroperoxidase promoters, ...of TTF-1 expression as determined by Northern blot analysis, reverse transcriptase-PCR, and ...
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Developmental lung expression and transcriptional regulation of Claudin-6 by TTF-1, Gata-6, and FoxA2
... Functional assays of reporter gene constructs were performed by transient transfection of Beas2B and A- 549 cells (American Tissue Culture Collection, ATCC, Manassas, VA) using FuGENE-6 HD reagent (Promega) [23]. Beas2B ...
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Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defect
... Complete TTF-1 absence in the ...lung, TTF-1 is expressed in the alveolar epithelium and is required for type II cell differentiation and surfactant protein ...with TTF-1 ...
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TTF 1/NKX2 1 up regulates the in vivo transcription of nestin
... presence of a signal in the entire neural tube in roughly 30% of the total embryos analyzed, with the notable exclusion of the telencephalic portions (Fig. 4 and Table 1). However, in 6 out of 7 ( ∼ 86%) of the ...
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Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature
... positive TTF-1 reaction in the in situ component as well as in the invasive component in this case gives strong support for primary breast ...reported TTF-1 posi- tive ductal carcinoma in situ ...
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IMP3 can predict aggressive behaviour of lung adenocarcinoma
... Hintergrund: Das Lungenkarzinom kommt meistens als nicht resektabler Tumor vor und die Diagnose kann nur in kleinen Biopsaten oder zytologisch gestellt werden. In der Gruppe der nicht kleinzelligen Lungenkarzinome kann ...
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Histopathological and immunohistochemical analysis of non small cell lung carcinoma with special emphasis on EGFR expression
... We evaluated the most commonly used panel of four immunohistochemical markers which included TTF-1, NAPSIN,P63 and CK5/6 on 50 cases. This IHC panel helped in sub typing the NSCLC into adenocarcinomas and ...
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Pathological characteristics and genetic features of melanin-producing medullary thyroid carcinoma
... for TTF-1, TG, CK19 and negative for calcitonin, whereas the tumor cells of melanin-producing MTC are positive for calcitonin and TTF-1 and negative for TG and ...
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Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas
... of TTF-1 protein (clone SPT24) by immunohistochemical staining of sections from paraffin embedded tumor samples in 247 primary breast cancers from the population- based Norwegian Breast Cancer Screening ...
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New insight into ectopic thyroid glands between the neck and maxillofacial region from a 42-case study
... Background: Ectopic thyroid is a rare disease. In the present study at the 9th People ’ s Hospital in Shanghai, China, 42 patients ’ ectopic thyroid glands between the neck and maxillofacial region were subjected to a ...
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Series Introduction: Intrinsic and innate defenses in the lung: intersection of pathways regulating lung morphogenesis, host defense, and repair
... The lung is a complex organ consisting of a series of branching tubules and alveoli that are highly vascu- larized to provide a large gas exchange surface. The respiratory tract is lined by endodermally derived ...
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Prognostic implications of immunohistochemistry markers for EGFR-TKI therapy in Chinese patients with advanced lung adenocarcinoma harboring EGFR mutations
... carcinoma has been previously reported. Only a few studies suggested that IHC markers and histologic features have a predictive role associated with the effectiveness of a specific treatment for lung adenocarcinoma ...
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<p>A comparison of diagnostic panels in the immunohistochemical analysis of lung cancer</p>
... three TTF-1 clones as well as to identify the best four- and two-marker panel to accurately distinguish SCC and ...of TTF-1 and p40 or p63 (one ADC marker and one SCC marker, respectively) to ...
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