Tubulin S
GENETICS OF THE TUBULIN GENE FAMILIES OF PHYSARUM
... T h e independent, strong criterion used to indicate that the benD mutant phenotype is determined by a @-tubulin structural gene mu- tation is that the benD210 allele en[r] ...
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An Innovation in the Cancer Therapy by the Interaction of Docetaxel to the Demethylpodophyllotoxin site of Tubulin
... Demethylpodophyllotoxin-treated tubulin show a small reduction in 25-S to 30-S peaks at ...of tubulin is seen at 0° but disappears if the temperature of tubulin incubated with ...
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Role of α Tubulin Acetylation and Protein Kinase D2 Ser/Tyr Phosphorylation in Modulation by Ghrelin of Porphyromonas gingivalis Induced Enhancement in Matrix Metalloproteinase 9 (MMP 9) Secretion by Salivary Gland Cells
... Moreover, relying on the literature evidence as to the role of cytoskeleton MT stabilization in the secretory vesicle trafficking [11] [15] [16], we assessed the impact of the LPS and ghrelin on the acinar cell secretion ...
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βIII-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer
... βIII- tubulin silencing and induction of apoptosis in pancreatic cancer ...βIII- tubulin is important in providing pancreatic cancer cells with a key survival advantage, thus allowing them to grow and ...
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Herpes Simplex Virus Type 1 Tegument Protein VP22 Induces the Stabilization and Hyperacetylation of Microtubules
... To confirm that the apparent VP22–a-tubulin colocalization represented an interaction between the two proteins, we used two drugs which are known to affect the stability of the MT network. First, both ...
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Revisiting the microtubule based quantum models of mind: tubulin bound GTP cannot pump microtubule coherence or provide energy for alpha <-> beta computation in stable microtubules
... Inorganic phosphate (Pi) binds to MTs with a low affinity (KD = 25 mM) and slows down the rate of GDP-subunit dissociation by about 2 orders of magnitude. Carlier et al. (1988, 1989) propose that Pi and its structural ...
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Different Functionals Domain of SpastinM87V Affect Cellular Microtubule Cutting
... The effects of different functional domains of Spastin M87V on the microtubule cutting of Hela cells were investigated. Spastin is a microtubule-cutting protein that can participate in many physiological functions, such ...
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A Tubulin Alpha 8 Mouse Knockout Model Indicates a Likely Role in Spermatogenesis but Not in Brain Development
... other tubulin studies showed that even with total absence of acetylated tubulin in the tes- tis, animals were still fertile, though some reduction in sperm function was noted when specifi- cally ...
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Molecular Analysis of the Alpha Tubulin Gene from the Microsporidium, Endoreticulatus sp Zhenjiang, Isolated from Bombyx mori
... the tubulin protein and rRNA sequence data in combination with phylogenetic analysis can be effective tools to redefine the phylogenetic relationship between microsporidia [7] ...
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Rationalization of paclitaxel insensitivity of yeast β tubulin and human βIII tubulin isotype using principal component analysis
... the tubulin struc- ture, Ile278 is in proximity to Leu217 and Leu 219 (Figure 5b) allowing the formation of a three-center hydrophobic staple, stabilizing the loop-loop ...
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Archaeal origin of tubulin
... the tubulin/FtsZ superfam- ily (see Additional File 2) was employed to build maxi- mum likelihood phylogenetic trees using FtsZ proteins as the ...bacterial tubulin sequences grouped within the eukaryo- tic ...
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The electrostatic analysis of TOG domains from XMAP215/DIS1 family members
... GTP-cap sizes should endow a MT with more resistance to growth fluctuations and there- fore lower its frequency of catastrophe. However, high-resolution experiments of growing MTs found that the catastrophe frequency ...
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Protective antibody and cytokine responses in mice following immunization with recombinant beta tubulin and subsequent Trypanosoma evansi challenge
... β tubulin specific IgG antibody, specifically of IgG2a isotype, with higher concentrations of TNF-α and lower concentrations of IL-4 in the serum following rTe- β-tubulin immunization in ...
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Synthetic paclitaxel-octreotide conjugate reversing the resistance of A2780/Taxol to paclitaxel in xenografted tumor in nude mice
... Peptide hormone-based targeted therapy to tumors has been studied extensively. Our previous study shows that somatostatin receptor expresses high level on drug- resistant human ovarian cancer. The paclitaxel-octreotide ...
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A Novel Step in β-Tubulin Folding Is Important for Heterodimer Formation in Saccharomyces cerevisiae
... important to note that the GimC/PFD complex seems to act asymmetrically on ␣- and -tubulin: ␣-tubulin levels are decreased more than -tubulin levels. Thus, in the absence of the GimC/PFD complex, ...
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Quick and Simple Detection Technique to Assess the Binding of Antimicrotubule Agents to the Colchicine-Binding Site
... Abstract Development of antimitotic binding to the colchicine-binding site for the treatment of cancer is rapidly expanding. Numerous antimicrotubule agents are prepared every year, and the determination of their binding ...
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HE4 promotes collateral resistance to cisplatin and paclitaxel in ovarian cancer cells
... in tubulin levels we observe is not due to a transcriptional effect, since we did not detect an in- crease in any tubulin gene in OVCAR8-WT cells treated with 20 nM rHE4 for 6 h (data not ...of ...
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Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6
... HDAC8 belongs to class I HDACs that are generally local- ized to nucleus and regulate gene expression. Although HDAC8 is well-characterized structurally, its precise cellu- lar loaclization, functional role and the ...
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Pironetin reacts covalently with cysteine 316 of α tubulin to destabilize microtubule
... on tubulin heterodimer in solution (without the other proteins used to obtain crystals) to ensure the modification of Cys316 was not the result of crystal packing or an artefact of T2R-TTL protein complex ...
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Antimitotic herbicides bind to an unidentifed site on malarial parasite tubulin and block development of liver stage Plasmodium parasites
... Protein affinity assay using the tubulin fusion proteins.. The affinity of the tubulin fusions for other proteins was determined by their ability to.[r] ...
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