Tumor aggressiveness
LGR5 is associated with tumor aggressiveness in papillary thyroid cancer
... with tumor risk stratification largely based on tumor histology, with only ...preference, tumor size, patient age, and highly variable operator-dependent preoperative ultrasonography) ...exact ...
12
TIPE2 acts as a biomarker for tumor aggressiveness and suppresses cell invasiveness in papillary thyroid cancer (PTC)
... suppressed tumor aggressiveness remains largely ...a tumor suppressor by inhibiting several classic oncogenic sign- aling pathways [15, ...the aggressiveness of PTC [25, 26, ...suppressed ...
12
Expression of Notch 1 receptor associated with tumor aggressiveness in papillary thyroid carcinoma
... thyroid cancer. The role of the Notch receptor or signaling pathway has not yet been fully elucidated in DTC. The role of the Notch signaling pathway in thyroid cancers may differ apparently according to their ...
5
NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib
... There is accumulating evidence that TrkA and its ligand Nerve Growth Factor (NGF) are involved in cancer development. Staurosporine derivatives such as K252a and lestaurtinib have been developed to block TrkA kinase ...
13
High expression of Sox10 correlates with tumor aggressiveness and poor prognosis in human nasopharyngeal carcinoma
... We discovered that high expression of Sox10 was correlated with advanced tumor stages and advanced N stage in NPC, which suggests that high expression of Sox10 correlates with locally invasive features. Many ...
7
CD44 enhances tumor aggressiveness by promoting tumor cell plasticity
... increased tumor malignancy and may contribute to tumor ...in tumor metastasis [12, ...of tumor endothelium ...promoting tumor cell invasiveness and epithelial-to- mesenchymal transition ...
13
Original Article High expression of Twist is associated with tumor aggressiveness and poor prognosis in patients with renal cell carcinoma
... plays an important role in the extreme malig- nant aggressiveness of sarcomatoid RCC. However, our findings suggest that Twist expres- sion at the edge of tumors is a strong indicator that Twist has a role in the ...
8
Pregnane X receptor activation induces FGF19 dependent tumor aggressiveness in humans and mice
... Our data are consistent with previous observations that PXR is antiapoptotic in colon (e.g., upregulates antiapoptotic BAG3, BIRC2, and MCL-1, while downregulating proapoptotic BAK1 and p53) (15, 54) and ovarian cancer ...
14
Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?
... Staining for MMP-13 is usually cytoplasmic but nuclear staining was also seen in some cases. This finding was in accordance with the results of other reports [49], its signif- icance is undetermined, but its presence ...
11
The pluripotency factor LIN28B is involved in oral carcinogenesis and associates with tumor aggressiveness and unfavorable prognosis
... gender, tumor differentiation and patients’ survival ...with tumor size and advanced clini- cal stages, but not the gender and tumor differentiation status as reported by Wu ...
9
Decreased expression of SLC39A14 is associated with tumor aggressiveness and biochemical recurrence of human prostate cancer
... investigated the function of SLC39A14 in LNCaP cells using gene overexpression and knockdown techniques. Further experiments presented here showed that the proliferation, migration, and invasion of PCa cells, following ...
9
Novel regulators of prostate cancer stem cells and tumor aggressiveness
... Typically, the “metastatic niche” is located at perivascular locations (124). CTCs and DTCs may, potentially, establish a metastatic niche through competition with hematopoietic stem cells (HSCs) for their niche at a ...
229
DNA methylation signature is prognostic of choroid plexus tumor aggressiveness
... and tumor samples were collected from many sources, including two large pediatric neuro-oncology centers: the Hospital for Sick Children (SickKids), Toronto, Ontario, and the Children’s Hospital of Los Angeles ...
16
Evaluation of tumor aggressiveness in women under 40 in western Algeria
... A BSTRACT : In Algeria, breast cancer is currently the most common malignant tumor and the leading cause of cancer mortality in women. It’s a complex and heterogeneous disease. It’s histological, phenotypic, and ...
9
Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion
... The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its expression and impact in human tumors is unclear. In this study, sortilin was analyzed by immunohistochemistry in a series of ...
14
Association between promoter polymorphisms of matrix metalloproteinase-1 and risk of gastric cancer
... by breast cancer cells and correlate with collagen degradation, trans- formation-like morphological changes in MCF-10A acini, and tumor aggressiveness. Biomed Res Int. Decock J, Hendric[r] ...
8
Increased PTEN gene expression in patients with endometrial carcinoma from areas of high risk depleted uranium exposure
... Recent studies have reported that overall cancer inci- dence has increased at least twofold amongst the Iraqi general population—especially in conflict areas involving Iraqi insurgents and occupation forces. According to ...
6
PubMedCentral-PMC5791515.pdf
... promotes tumor proliferation and mi- gration, suggesting that reactive astrocytes may potentiate tumor aggressiveness after ...vitro tumor growth showed a marginal increase compared with the ...
12
A favorable tumor size to define papillary thyroid microcarcinoma: an analysis of 1176 consecutive cases
... the tumor aggressiveness will aid the physician in choosing the optimal individualized patient ...the tumor is widely used to predict the aggressiveness of PTMC to aid clinical decision making ...
8
Tumor-initiating cell frequency is relevant for glioblastoma aggressiveness
... on tumor incidence and mice ...and tumor aggressiveness, implemented through in vivo LDA in immunodeficient recipient mice [15, ...and tumor invasiveness) and TIC ...
13