tumor-associated macrophage
GATA3 expression correlates with poor prognosis and tumor- associated macrophage infiltration in peripheral T cell lymphoma
... with tumor-associated macrophage (TAM) infiltration, as indicated by the presence of CD68-positive ...M2-type macrophage differentiation through a GATA3-dependent ...
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Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial–mesenchymal transition
... are associated with chronic inflammation, which plays a role in tumor ...the tumor mass. Macrophages are highly infiltrative in the tumor microenvironment and secrete a series of inflammatory ...
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Class A1 scavenger receptor modulates glioma progression by regulating M2-like tumor-associated macrophage polarization
... with tumor grade ...to tumor tissue, and were almost twice as numerous as resident microglia in glioma tissues ...M2-like tumor-associated macrophage (TAM) polarization in mice by ...
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Hedgehog signaling promotes tumor associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment
... Preparation of single-cell suspensions from tumors. The isolation of TAMs and leukocytes was previously described (40) and was slight- ly modified for this study. Briefly, tumors were excised from mice and digested with ...
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CD163+ tumor-associated macrophage is a prognostic biomarker and is associated with therapeutic effect on malignant pleural effusion of lung cancer patients
... Members of the TLR family play key roles in both innate and adaptive immune responses [38]. TLR proteins enable host to recognize a large number of pathogen-associated molecular patterns such as bacterial ...
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Prognostic impact of tumor-associated macrophage infiltration in non-small cell lung cancer: A systemic review and meta-analysis
... curve. Tumor stage is an important prognostic factor. The differences in tumor stages between the high and low TAM density groups may be a confounding factor for the observation of ...
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Increased IL-10 mRNA expression in tumor-associated macrophage correlated with late stage of lung cancer
... both tumor cells and stromal cells ...of tumor growth and ...not associated with NSCLC stage, lymph metastasis, lymphovascular invasion or histological ...
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Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA
... inhibit tumor metastasis or improve tumor radiosensi- tivity [10, 11], and miRNA mimic transfection showed that miR-146b-5p could inhibit the migration of endothe- lial cells ...of tumor blood ...
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Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells
... The gastric cancer cell line MFC,MGC-803 were pur- chased from the Chinese Academy of Sciences Cell Bank of Type Culture Collection. Murine bone marrow–de- rived macrophages (BMDM) were isolated and activated as ...
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Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment
... the tumor-promoting and tumor-inhibiting roles of three major TAM subtypes, namely, the M1 cytotoxic, the M2 tumor growth-promoting, and the TEM vasculature- stabilizing ...the tumor growth, ...
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Neuroendocrine-like cells -derived CXCL10 and CXCL11 induce the infiltration of tumor-associated macrophage leading to the poor prognosis of colorectal cancer
... the tumor microenvironment along with their secreted cytokines, such as IL-6, interact with prostate cancer cells and play an important role in neuroendocrine differentiation and the prognosis of prostate cancer ...
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Targeting lipid metabolism to overcome EMT-associated drug resistance via integrin β3/FAK pathway and tumor-associated macrophage repolarization using legumain-activatable delivery
... In summary, we proposed a dual-targeting nano codelivery system for modulating lipid metabolism as a novel strategy to reverse drug resistance in cancer therapy. SV has been reported to be able to inhibit tumorigenesis ...
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Tumor-associated macrophage expression of interferon regulatory Factor-8 (IRF8) is a predictor of progression and patient survival in renal cell carcinoma
... intratumoral macrophage behavior and patient outcome are ...in macrophage expression of the transcriptional regulator for myeloid commitment and function, interferon regulatory factor-8 (IRF8), could ...
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One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment
... by tumor-associated macrophage (TAM), NK cells, T cells, B cells, polymorphonuclear leukocytes (PMN), and dendritic cells (DCs) [1] in the tumor sites should not be ...the tumor immune ...
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<p>Tumor-Associated CD163<sup>+</sup> M2 Macrophage Infiltration is Highly Associated with PD-L1 Expression in Cervical Cancer</p>
... in tumor cells is not clear. Tumor-associated macrophages, the main cells in the tumor stroma, are important components of the inhibitory tumor ...in tumor immune ...with ...
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Preconditioning of murine mesenchymal stem cells synergistically enhanced immunomodulation and osteogenesis
... γ plus TNF-α were included as a positive control, be- cause this conditioning has been demonstrated previ- ously to enhance the modulation of both innate and adaptive immune responses [17, 18]. Activation of proin- ...
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Tumor suppressor ARF regulates tissue microenvironment and tumor growth through modulation of macrophage polarization
... in tumor progression and metastasis [1, ...that tumor suppressor ARF plays an important role in the regulation of the immune system [15] as well as in the modulation of the M1/M2 macrophage phenotype ...
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Obesity is associated with macrophage accumulation in adipose tissue
... tissue macrophage content and indicators of adiposity pro- vides a mechanism for the increased adipose tissue pro- duction of proinflammatory molecules and acute- phase proteins associated with ...types ...
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MiR-98 modulates macrophage polarization and suppresses the effects of tumor-associated macrophages on promoting invasion and epithelial–mesenchymal transition of hepatocellular carcinoma
... regulates macrophage polarization from M2 to M1 in HCC-conditioned ...of tumor growth, invasion, and metastasis ...diated macrophage polarization from M2 to M1 and reg- ulation of cytokines may lead ...
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CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models
... Osteosarcoma is the most common bone tumors in children and adolescents. Despite intensive chemotherapy, patients with advanced disease still have a poor prognosis, illustrating the need for alternative therapies. In ...
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