tumor budding
TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer
... Tumor budding in colorectal cancer is likened to an epithelial-mesenchymal transition (EMT) characterized predominantly by loss of E-cadherin and up-regulation of E-cadherin repressors like TWIST1 and ...
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Automatic evaluation of tumor budding in immunohistochemically stained colorectal carcinomas and correlation to clinical outcome
... Background: Tumor budding, meaning a detachment of tumor cells at the invasion front of colorectal carcinoma (CRC) into single cells or clusters (<=5 tumor cells), has been shown to ...
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The cell surface mucin podocalyxin regulates collective breast tumor budding
... Tumor budding, which is regarded to be an important component of local tumor cell dissemination, has signifi- cant prognostic significance in a number of solid tumor types, including breast ...
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Original Article Hypoxia induced HIF-1α expression promotes angiogenesis, tumor budding cell survival and cell proliferation arrest in high-grade tumor budding colorectal carcinomas
... high-grade tumor bud- ...at tumor invasive front where the tumor budding cells are present, can not only provide oxygen and nutrient to maintain the budding tumor cell survival, ...
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Original Article Tumor budding and size as risk factors of lymph node metastasis in early colorectal cancer
... the tumor repre- sents the ratio of circumference of tumor to luminal ...which tumor size, depth of submucosal invasion, histologic grade, lympho- vascular invasion, tumor budding and ...
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Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer
... c-MET and its ligand HGF are frequently overexpressed in colorectal cancer (CRC) and increased c-MET levels are found in CRC liver metastases. This study investigated the role of the HGF/c-MET axis in regulating ...
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Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget
... by tumor buds ...pushing tumor borders accompanied by dense PTL inflammation ...targeting tumor budding cells for destruction, hence their frequent absence at the invasive front in tumors with ...
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Tumor Budding in Breast Carcinoma: Relation to E-Cadherin, MMP-9 Expression, and Metastasis Risk
... grade tumor budding ...grade tumor budding (p=0.001). High grade tumor budding was a significant, independent risk factor of metastasis in breast carcinoma ...conclusion, ...
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Tumor budding as a risk factor of lymph node metastasis in submucosal invasive T1 colorectal carcinoma: a retrospective study
... node metastasis. Data of malignant polyps in two patients who underwent colonoscopic polypectomy at a local clinic before radical surgery could not be found. The tumor budding was found in five (83.3%) of ...
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Tumor budding for predicting prognosis of resected rectum cancer after neoadjuvant treatment
... factors, tumor progression at the time of diagnosis, and adjunct- ive therapy (surgery, adjuvant and/or neoadjuvant treat- ment) [5, ...as tumor budding (TB), poorly ...
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Accumulation of FOXP3+T-cells in the tumor microenvironment is associated with an epithelial-mesenchymal-transition-type tumor budding phenotype and is an independent prognostic factor in surgically resected pancreatic ductal adenocarcinoma
... as tumor-associated macrophages (TAMs) in the tumor development has been recognized, only few previous reports indicate a role of macrophages in EMT ...and tumor budding, support an ...
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<p>Desmoplastic Reaction and Tumor Budding in Cervical Squamous Cell Carcinoma are Prognostic Factors for Distant Metastasis: A Retrospective Study</p>
... the tumor cell has the potential to disseminate or ...of tumor budding. 11,22 The tumor dedifferentiation phenotypes at the invasive border are a morphologic feature of epithelial- mesenchymal ...
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Decreased miR-320a promotes invasion and metastasis of tumor budding cells in tongue squamous cell carcinoma
... of tumor budding, miR-320 and Suz12 in TSCC, we performed a clinicopathological analysis of 100 patients, of which 48 were male and 52 were ...in tumor tissues than the pericancerous epithelium and ...
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Prognostic significance of tumor budding and single cell invasion in gastric adenocarcinoma
... high-grade tumor budding was observed in ...differentiated. Tumor budding, single cell invasion, and large cell invasion were indepen- dent of age, sex, and smoking or drinking history ...
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Novel histopathologic feature identified through image analysis augments stage II colorectal cancer clinical reporting
... significance: tumor budding (TB) [16, 17], poorly differentiated clusters (PDC) [11, 18], lymphatic vessel invasion (LVI) [19], lymphatic vessel density (LVD) [20, 21] and the tumor to stroma ratio ...
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Combined aberrant expression of E-cadherin and S100A4, but not β-catenin is associated with disease-free survival and overall survival in colorectal cancer patients
... high tumor budding and poor prognosis [11], whereas other studies did not find such a relationship ...and tumor budding or overall survival in our patient ...were tumor budding ...
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Novel histopathologic feature identified through image analysis augments stage II colorectal cancer clinical reporting Peter D. Caie 1,2 , Ying Zhou 3, Arran K. Turnbull3 , Anca Oniscu 1,2 , David J. Harrison 1,2
... significance: tumor budding (TB) [16, 17], poorly differentiated clusters (PDC) [11, 18], lymphatic vessel invasion (LVI) [19], lymphatic vessel density (LVD) [20, 21] and the tumor to stroma ratio ...
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KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer
... and budding of CRC cells, leading the primary tumor to distant sites such as the liver and ...of tumor budding which retains aberrant Wnt/β-catenin signaling [19, 21, ...in tumor ...
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High expression of muscarinic acetylcholine receptor 3 predicts poor prognosis in patients with pancreatic ductal adenocarcinoma
... six tumor cell layers or detached tumor cell groups at the advancing ...ITF/tumor budding cells; moreover, nearly half of the ITF/tumor budding cells (11/29, ...
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Actin and Endocytosis in Budding Yeast
... However, other lines of evidence have pointed to twinfilin- promoting actin-filament disassembly or turnover, including: (i) twinfilin genetically interacts with cofilin in yeast and flies (G[r] ...
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