Tumor-Derived
Potential theranostics of circulating tumor cells and tumor-derived exosomes application in colorectal cancer
... Circulating tumor cells; TDEs: Tumor-derived exosomes; CT: Computed tomography; MRI: Magnetic resonance imaging; TEPs: Tumor-educated platelets; LOC: Lab-on-a-chip; NGS: Next-generation ...
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Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment
... TAMs: tumor-associated macrophages; TEXs: tumor-derived exosomes; TFEB: transcription factor EB; TGF- β : transforming growth factor- β ; TGN: trans-Golgi network; Th17: T helper cell 17; TLR2: ...
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The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications
... that tumor cells produce more exosomes than their normal counterparts and can be a useful diagnostic biomarker ...[28]. Tumor-derived exo- somes are believed to be important mediators of intercel- ...
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Basics and applications of tumor-derived extracellular vesicles
... that tumor-derived exosomes with specific integrin expres- sion profiles regulated organotropic metastasis ...of tumor-derived EVs from human plasma provide valuable information for cancer ...
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Tumor-derived exosomes in cancer progression and treatment failure
... During tumor invasion, constant communication occurs between tumor cells and surrounding stromal cells via ...stromal tumor cells invade the interstitial stroma by releasing oncogenic protein ...
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The functions and clinical applications of tumor-derived exosomes
... in tumor-derived vesicles play important roles in monocyte differentiation [124- ...in tumor-bearing mice, blood-borne exosomes positive for CD11b could suppress tumor Ag- specific responses ...
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Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC+ tumors respond to PD1/PD-L1 blockade therapy
... High levels of circulating soluble NKG2D ligands have been associated with a poor clinical outcome in many solid tumors and poor response of PD1/PD-L1 blockade therapy as shown in melanoma patients [24–26, 30, 41, 42]. ...
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Tumor derived granulocyte colony stimulating factor diminishes efficacy of breast tumor cell vaccines
... occult tumor cells before a recur- rence can ...autologous tumor cell vaccines (ATCVs) comprise a promising class of vaccines capable of inducing personalized, polyclonal anti-tumor immune responses ...
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The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression
... Results: RT-PCR was used to show that, among the adult and pediatric brain tumor-derived cells tested, U-87 glioma cells expressed the highest levels of G6PT mRNA. U-87 cells lacked the microsomal catalytic ...
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<p>Tumor-Draining Lymph Secretome En Route to the Regional Lymph Node in Breast Cancer Metastasis</p>
... somes. Tumor-derived exosomes were shown to promote progression, invasion, and metastasis of cancer cells and play a signi fi cant role in suppressing the immune responses against the ...promote tumor ...
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Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice
... of tumor-bearing mice for phospho-Stat3 (p-Stat3) and VEGF ...Stat3-dependent, tumor-derived MDSC–mediated angiogen- ...in tumor-associated myeloid cells contributes to elevated expression of ...
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Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients
... aggressive tumor biology and even tumor-derived signatures have poor accuracy in predicting ER-negative patient survival due to the uniformly poor survival of this group ...
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Vascularized Tissue-Engineered Model for Studying Drug Resistance in Neuroblastoma
... Further studies using three markers (MYCN, SOX2, CD31) confirmed the high heterogeneity of engineered tumors (Supplementary Figure S10b). We identified five different cell types forming a vessel and remaining after drug ...
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Remodeling the Microenvironment before Occurrence and Metastasis of Cancer
... both tumor cell growth and invasion in the bone. Tumor-derived secreted factors (TDSFs) are crucial in creating a supportive microenvironment at the metastatic ...cytokines derived from the ...
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Pharmacogenomic analysis of patient derived tumor cells in gynecologic cancers
... gynecologic tumor-derived ...primary tumor tissues and matched PDCs, and the distance reflects the number of cases that harbor respective ...between tumor tissue specimens and matched PDCs ...
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Exosome removal as a therapeutic adjuvant in cancer
... whereby tumor cells secrete vast amounts of im- mune inhibitory exosomes that hinder anti-cancer immune ...responses. Tumor-derived exosomes are involved in the fundamental aspects of cancer ...
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Patient derived xenograft models in musculoskeletal malignancies
... fibrous tumor xeno- grafts predicted high sensitivity to a combination of doxorubicin and dacarbazine, and a phase II randomized study has been started to validate these preclinical results ...the tumor, ...
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TWO NEW HEREDITARY TUMORS IN DROSOPHILA
... The tumors are probably derived from embryonic rudiments (imagi- nal discs) (in the first tumor the neuroblast and hypodermal tissue) of the larva. I n the first tumor many[r] ...
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Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy
... MSC- derived exosomes could be a novel therapeutic platform for future clinical consideration due to the fact that MSC-derived exosomes are well tolerated in patients during the treatment of GVHD ...MSC- ...
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Differentiation of Low Grade Oligodendrogliomas from Low Grade Astrocytomas by Using Quantitative Blood Volume Measurements Derived from Dynamic Susceptibility Contrast Enhanced MR Imaging
... in tumor blood volume and ...rCBV derived from DSC MR imaging better correlates with histopathologic find- ings than does rCBV derived from ...
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