Tumor heterogeneity
Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications
... of tumor cells can coexist within the same tumor. This intra-tumor heterogeneity will have clinical implications and it is therefore important to identify factors that drive or suppress such ...
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Circulating Tumor Cells as a Tool for Assessing Tumor Heterogeneity
... the heterogeneity state of cancer cells, as numerous emergent studies have demonstrated their consequences in tumor evolution and therapeutic response [7, 9, 10, ...the tumor ecosystem and between ...
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Multipotent luminal mammary cancer stem cells model tumor heterogeneity
... exact tumor subtypes arising from the differentiation of Py230 cells in vivo ...during tumor progression requires further ...Py230-derived tumor het- erogeneity ...while tumor ...
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Quantitative analyses to study tumor clones dynamics and tumor heterogeneity
... intra-patient tumor heterogeneity in the clinical setting, here I report studies aimed to characterize the genomics of metastatic prostate cancer through “liquid biopsy”, ...all tumor lesions present ...
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Understanding tumor heterogeneity as functional compartments superorganisms revisited
... Given that tumorigenesis requires acquisition of multi- ple mutations during a period of many years, stem cells are - due to their long life span - reasonable candidates for the accumulation of mutations ultimately ...
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Tumor heterogeneity measurement using [18F] FDG PET/CT shows prognostic value in patients with non-small cell lung cancer
... lying tumor biology and heterogeneity in specific tumor biology ...characteristics. Tumor heterogeneity refers to features at a cellular level ...and tumor metabolism) as well as ...
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Breast cancer intra tumor heterogeneity
... spatial heterogeneity in tumors, methodologies that allow for in situ topological genotyping, assessment of gene copy number aberrations, and expression and/or activation of the protein products of genes targeted ...
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Tumor heterogeneity in neoplasms of breast, colon, and skin
... the heterogeneity model are established on the basis of the assumption of the mathematical model of tumor ...The heterogeneity model assumes that new subpopulations in tumor inherit essential ...
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Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation
... of tumor heterogeneity, investigation of genetic suscepti- bility, and characterization of mutational motifs to better understand underlying mutational ...[1-5]. Tumor subpopulations possessing ...
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Human Cancer Modeling: Recapitulating Tumor Heterogeneity Towards Personalized Medicine
... An attractive approach in personalized modeling is to select for xenografts that naturally encompass certain molecular abnormalities. Although such targeted ab- normalities can be created by engineering GEMMs, using ...
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Evolving concepts of tumor heterogeneity
... the tumor secretome provide compelling evidence for the TME as a major contributor to compositional tumor ...the tumor suppressor p53, a prominent hub in DNA-induced cellular stress networks and ...
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Assessment of tumor heterogeneity: an emerging imaging tool for clinical practice?
... tuberculomas (2.25 ± 0.08) (p < 0.0001). The 3D fractal dimension also differentiated adenocarcinomas (n 0 61) from squamous cell carcinomas (n 0 9) [37]. In the second study, the authors found that bronchoalveolar ...
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Using single-cell multiple omics approaches to resolve tumor heterogeneity
... epigenetic heterogeneity progress through sub-clonal branched evolution rather than through linear expansion ...tumour heterogeneity computationally using single-cell genomics data and determine functional ...
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Tumor heterogeneity as a rationale for a multi-epitope approach in an autologous renal cell cancer tumor vaccine
... This leads to the conclusion that all components needed for a (broad) immune response were present in all TCLs in an immunological active form. Since the presence of both (a mix- ture of TAA and danger signal) was proven ...
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Alterations of lymph nodes evaluation after colon cancer
... and tumor heterogeneity on nodal ...and tumor-related features, including gender, age, T stage, histology, tumor differentiation, tumor size and tumor ...stage, tumor ...
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Evaluation and consequences of heterogeneity in the circulating tumor cell compartment
... several tumor types ...circulating tumor (ct) DNA, derived from tumor deposits and lysed CTCs, also has the potential to serve as a marker for tumor burden, therapy response, and even therapy ...
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<p>Heterogeneity of targeted lung lesion predicts platinum-based first-line therapy outcomes and overall survival for metastatic triple-negative breast cancer patients with lung metastasis: a “PET biopsy” method</p>
... Our results suggested that the new measurement method of tumor heterogeneity, LI, was a potential predictor of fi rst- line therapy response for mTNBC with a cutoff value of 0.56, which corresponds to the ...
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The global cancer genomics consortium’s symposium: new era of molecular medicine and epigenetic cancer medicine - cross section of genomics and epigenetics
... the tumor recurrence via contributing to tumor ...exhibit tumor stem cells characteristics and eventually lead to cell population with increased heterogeneity with respect to cell growth, ...
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A Simple Computed Tomography Scoring System to Predict Histological Malignancy of Solitary Fibrous Tumors of the Pleura
... malignancy: tumor size ≥ 10 cm, as well as intratumoral necrosis and ...study, tumor heterogeneity either with or without contrast injection, intratumoral fluid density areas, and a pleural effusion ...
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The degree of intratumor mutational heterogeneity varies by primary tumor sub-site
... primary tumor and in most cases from two separate locations of a metastatic lymph ...patient’s tumor tissues information are summarized in Supplemental Table ...
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