Tumor-infiltrating CD8+ T cell
Pre-selection of PD-1+ Tumor-Infiltrating CD8+ T cells improves the efficacy of adoptive T-cell Therapy
... from tumor fragments, or digested tumor cell suspensions, in the presence of high dose of ...total tumor lesion size of about 3 cm in diameter is required to successfully expand ...autologous ...
5
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma
... of T cell surface markers and intracellular tar- gets was measured by fluorescence cytometry (MACSQuant, Miltenyi Biotec) and analyzed by FlowJo software (Tree Star ...VIT4), CD8 peridinin ...
14
PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors
... selectively CD8 + T-cell subsets expressing both activating and inhibitory receptors Because treatment with anti-PD-L1 has major effects on the expansion of the CD8 + T-cell ...
14
Suppression of antitumor immunity by IL 10 and TGF b producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells
... ⫹ T cells may play a critical role in progression of a number of cancers (2, 9, ...non-small cell lung cancer, natural Treg cells from the tumors have been shown to inhibit proliferation of autologous, but ...
9
The prognostic influence of tumor infiltrating Foxp3+CD4+, CD4+ and CD8+ T cells in resected non-small cell lung cancer
... Lung tissue specimens from 80 newly diagnosed and un- treated NSCLC patients who underwent surgical resection for NSCLC (pathological stage I-III) and 16 control group subjects who underwent surgery due to recurrent ...
9
Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma
... better overall survival (OS) (HR, 0.32; 95% CI, 0.10-0.98; P=0.046, Table 3 and Fig 4B), and longer progression-free survival (PFS) by univariate analysis (HR, 0.31; 95% CI, 0.11-0.85; P=0.024, Table 3 and Fig 4C). ...
10
Tumor-derived exosomes induce CD8+ T cell suppressors
... of tumor-specific cytotoxic CD8 + T cells to the tumor micro- environment is now understood to be generally associated with favorable clinical outcomes, even in patients not receiving ...
15
The clinical significance of tumor infiltrating neutrophils and neutrophil to CD8+ lymphocyte ratio in patients with resectable esophageal squamous cell carcinoma
... cytotoxic CD8+ lymphocytes constitute one of the most important effector mechanisms of anti-tumor immunity ...humans, CD8+ lymphocytes have been shown to play an important role in the host's defense ...
10
Enrichment of inflammatory IL 17 and TNF α secreting CD4+ T cells within colorectal tumours despite the presence of elevated CD39+ T regulatory cells and increased expression of the immune checkpoint molecule, PD 1
... However, tumor infiltrating T cells contain a number of different functional subtypes, which can have either pro- or antitumor ...IFN-γ-producing CD8 T cells play a key role in the ...
11
Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens
... both tumor and surrounding stroma). Tumor cell mask was visualized as described above, utilizing a cocktail of anti- CA9 and anti-cytokeratin antibodies with streptavidin- peroxidase polymer (bound ...
13
Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes
... renal cell carcinoma, lung cancer, mismatch repair-deficient colorectal cancer, and bladder cancer—characterized by a high prevalence of neo-antigens, elevated PD-L1 expression, and robust infiltration of ...
9
The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy
... in tumor- infiltrating T cells during tumor progression in GL261 glioma orthotopic murine glioma model, the survival time of which is around 30 days ...and CD8 + T cells grad- ...
13
Comprehensive analyses of tumor immunity: implications for cancer immunotherapy
... with infiltrating immune cells could be a useful criterion for selecting putative cancer vaccine targets, although the utility of this criter- ion awaits future experimental ...with infiltrating immune ...
16
Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells
... B cell and CD8 + T cell densities in HPV-positive and HPV-negative OPSCC samples, we observed substantial variability in the levels of tumor-infiltrating immune cells in patients ...
16
Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells
... gous tumor-cell recognition by melanoma TILs by reducing cytokine production and metabolic ...however, tumor antigens are not expressed homoge- neously throughout the tumor tissue, and their ...
16
Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma
... % CD8 T cell infiltrate and # of CD8 positive ...of CD8 positive T cells/mm^2 determined using PerkinElmer and ...On tumor cells B) on CD8+ T cells and C) on ...
11
Prognostic value, localization and correlation of PD-1/PD-L1, CD8 and FOXP3 with the desmoplastic stroma in pancreatic ductal adenocarcinoma
... either CD8 (1:100, clone C8/144B; Dako M7103, UK), FOXP3 (1:100, clone 236A/E7; Abcam AB20034, UK), PD-1 (1:80, clone NAT105; Cell Marque CMC31529030, UK) and PD-L1 (1:200, clone E1L3N(R); Cell ...
13
The Majority of Infiltrating CD8+ T Cells in the Central Nervous System of Susceptible SJL/J Mice Infected with Theiler's Virus Are Virus Specific and Fully Functional
... I-restricted CTL-mediated lysis in our experiments (Fig. 4). Our results indicate that the association of disease resistance with the H-2D genetic locus is not due to the fact that only H-2D molecules can present viral ...
9
CD8 T cell tumor infiltration following Tc1 or Tc2 therapy
... advantages for using an in vivo model, having an in vitro model would allow for future studies to contribute to our understanding of the mechanisms of Tc1 and Tc2 cell migration. Currently, our in vitro model ...
183
Clonal T cell responses in tumor infiltrating lymphocytes from both regressive and progressive regions of primary human malignant melanoma
... express tumor-associated antigens that are recognized by syngeneic T ...the tumor, i.e., T lympho- cytes and macrophages are infiltrating both primary and meta- static ...of ...
7