tumor infiltrating T cells
Human Papillomavirus Type 33 E7 Peptides Presented by HLA-DR*0402 to Tumor-Infiltrating T Cells in Cervical Cancer
... tumor cells. Some reports demonstrated the presence of HPV-specific T cells after in vitro stimulation with peptides (11) or used autologous dendritic cells in order to expand ...
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Noninvasive detection of tumor infiltrating T cells by PET reporter imaging
... of tumor-reactive T cells can successfully reduce tumor burden; however, in rare cases, lethal on-target/off-tumor effects have been ...engineered cells with high sensitivity and ...
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Collagen density regulates the activity of tumor-infiltrating T cells
... for T cells, purified T cells (isolated with anti-CD3 microbeads, Miltenyi Biotec), or purified CD8 positive cells (isolated with CD8 MicroBeads, Miltenyi Biotec) were transiently ...
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The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy
... in tumor- infiltrating T cells during tumor progression in GL261 glioma orthotopic murine glioma model, the survival time of which is around 30 days ...immune cells showed that ...
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Tumor infiltrating BRAFV600E specific CD4+ T cells correlated with complete clinical response in melanoma
... melanoma originating on the left foot and was treated with wide excision, completion lymph node dissection, and adjuvant ipilim- umab at 3 mg/kg every 3 weeks for 4 doses, then every 3 months for maintenance. Before ...
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Pure Choriocarcinoma of Testis with Tumor Infiltrating Lymphocytes and Granulomas
... histological tumor types. The immunocompetent cells that infiltrate tumors are mostly T-lymphocytes and macro- phages, with a few B-lymphocytes and very few ...
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Suppression of antitumor immunity by IL 10 and TGF b producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells
... ⫹ T cells in the lung is also consistent with studies on non-small cell lung cancer, which demonstrated low concentrations of IFN- ␥ and elevated IL-10 and TGF-  at the tumor site (23) and high ...
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Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance
... of tumor pathologic features ...in tumor with MMR defects by T-cells, macrophages, and natural killers, infiltration might be increased enhancing immune surveillance mechanisms ...of ...
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Development and validation of a molecular prognostic index of bladder cancer based on immunogenomic landscape analysis
... lower infiltrating percent- age of T cells CD8, T cells CD4 memory activated or T cells follicular helper were significantly associated with the poor prognosis of ...of ...
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Pre-selection of PD-1+ Tumor-Infiltrating CD8+ T cells improves the efficacy of adoptive T-cell Therapy
... the T-cell recognition against both defined and un-defined tumors antigens, and in the context of all possible MHC molecules, rather than the single specificity of tg-TCR- or CAR-transduced T cells, ...
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IL 12 triggers a programmatic change in dysfunctional myeloid derived cells within mouse tumors
... ferred T cells infiltrating the extra- vascular space of tumors treated with IL-12 cells, but not mock cells (Figure ...mock cells, although this observa- tion was more an ...
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OX40 expression enhances the prognostic significance of CD8 positive lymphocyte infiltration in colorectal cancer
... of infiltrating CD8+ T cells are associated with improved disease-free and overall survival in CRC [4-8] and the analysis of tumor infiltration by immune cells has been suggested to ...
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PD 1 + polyfunctional T cells dominate the periphery after tumor infiltrating lymphocyte therapy for cancer
... after T cell activation upon recognition of tumor cells (Borch TH, personal ...+ T cells in heavily expanded TILs consist of antigen-experienced effector memory T cells ...
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Focus on the target: the tumor microenvironment, Society for Immunotherapy of Cancer Annual Meeting Workshop, October 24th-25th 2012
... TILs: Tumor infiltrating T lymphocytes; TECs: Tumor endothelial cells; IHC: Immuohistochemistry; ETBR: Endothelin type B receptor; ICAM-1: Intercellular Adhesion Molecule 1; FasL: ...
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Checkpoint blockade in solid tumors and B-cell malignancies, with special consideration of the role of CD200
... in tumor-associated or tumor-infiltrating cells in ovarian tumor-bearing mice and that blockade of any one of PD-1, LAG-3, or CTLA-4 alone using blocking antibodies or knockout mice led ...
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Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells
... TILs/autologous tumor cells ...autologous tumor cells in untreated culture condition, in presence of Ado or ZM 241385 + ...autologous tumor cells in resting condition, in ...
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Cancer-induced Defective Cytotoxic T Lymphocyte Effector Function: Another Mechanism How Antigenic Tumors Escape Immune-mediated Killing
... the tumor, induce the transitory proliferative and lytic defects in ...for tumor-induced TIL anergy is unknown and its understanding is a major goal of the ...or infiltrating host cells that ...
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Isolation of T cell receptor specifically reactive with autologous tumour cells from tumour-infiltrating lymphocytes and construction of T cell receptor engineered T cells for esophageal squamous cell carcinoma
... Background: T cell receptor-engineered T cells (TCR-Ts) therapy is a promising cancer treatment ...high-avidity T cell receptors (TCRs) directed against neoantigens derived from somatic ...
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Comprehensive analyses of tumor immunity: implications for cancer immunotherapy
... cytotoxic T-cell infiltration inde- pendently predicts better outcome in liver [22] and rectal [23] ...found infiltrating CD8 T cells to be associated with sur- vival in univariate analysis ...
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Tumor infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice
... of tumor cells from CTLs depends on ROS ...EL-4 cells were treated for 10 minutes with ...panels). Cells were labeled with SIINFEKL peptide (SIIN) conjugated with FITC; peptide binding was ...
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