Tumor-initiation
Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production
... in tumor development of breast and colon cancer ...including tumor initiation (formation) and promotion ...promote tumor initiation in tumor ...
14
Estrogen promotes estrogen receptor negative BRCA1 deficient tumor initiation and progression
... in tumor development and progression [12, ...in tumor initiation and ...proficient tumor cells in vitro and tumorigenesis in ...mammary tumor cells, promoting their properties in ...
17
Targeting Zfp148 activates p53 and reduces tumor initiation in the gut
... The role of Znf148 (human Zfp148 homologue) in human CRC was recently investigated [9]. In familial adenomatous polyposis, expression of Znf148 increased from normal mucosa to adenomas to carcinomas, thus supporting the ...
10
Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity
... the tumor vasculature or the tumor ...in tumor cells it is quite variable from one tumor to another [15, ...in tumor angiogenesis. However, there is evidence that expression by ...
19
Collagen density promotes mammary tumor initiation and progression
... excessive tumor burden (not ...PyVT/Col1a1 tumor-bearing glands appear to be increased relative to non-tumor bearing col- lagen-dense glands (Figure ...lowing tumor initiation, and may ...
15
Genes Involved in Viral Carcinogenesis and Tumor Initiation in Hepatitis C Virus-Induced Hepatocellular Carcinoma
... HCC development. Each of these scenar- ios involves different genetic and epige- netic alterations, chromosome aberra- tions, gene mutations, and altered molecular pathways (18–25). Moreover, the study of the ...
10
PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target
... metastases. Pthrp ablation in the mammary epithelium of the PyMT-MMTV breast cancer mouse model caused a delay in primary tumor initiation, inhibited tumor progression, and reduced metastasis to ...
16
The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression
... During the survival analyses of Ctnnb1 mutant mice, we observed that homozygous Pygo2 knockout animals survived the initial phase of tumor initiation for up to ten weeks after induction. However, these ...
21
RhoE is required for contact inhibition and negatively regulates tumor initiation and progression
... different tumor types have suggested a positive correlation of RhoE expression with tumor malignancy [20-26] but also a tumor suppressive function for RhoE [7, ...or tumor types, alterations ...
12
Specific inhibition of one DNMT1-including complex influences tumor initiation and progression
... Findings: Our data indicated that the use of an unspecific DNMT inhibitor (5aza-2deoxycytidine), a DNMT1 inhibitor (procainamide) or peptides disrupting the DNMT1/PCNA, DNMT1/EZH2, DNMT1/HDAC1, DNMT1/DNMT3b and DNMT1/HP1 ...
7
Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma
... primary tumor samples and associated survival data (n = 259) were ranked by the ratio of the RPKM (reads per Kb per million mapped reads) values of PKM2 and PKM1 isoform-specific ...
9
On the Question of Crown-Gall Tumor Initiation by DNA of Bacteriophage PS8
... Similarly, carnosine, an analogue of a natural crown-gall growth factor 7, applied at 0.5 mg/ml with 1.7 x 1011 PFU/ml of phage PS8 to 30 sunflower seedlings failed to provide any eviden[r] ...
6
Cancer as an immune-mediated disease
... to tumor growth is now recognized, the role of the immune system in controlling tumor initiation and expansion as well as cancer progression has been controversial for some ...
6
β1 integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer
... ErbB2-mediated tumor induc- tion [80]. Although a signifi cant 33-day delay in tumor onset was observed, all of the mice developed mammary tumors histologically similar to their control counterparts ...
10
Cancer Etiology: Variation in Cancer Risk among Tissues is Poorly Explained by the Number of Gene Mutations
... to tumor initiation and the number of cell divisions occurring during tumor growth is similar among tissues, here I use whole genome sequencing information from 22,086 cancer samples and incidence ...
15
Effect of Stromal Cells in Tumor Microenvironment on Metastasis Initiation
... where tumor cells reside is called the tumor microenvironment (TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM), stromal cells, immune/inflammatory cells, secreted ...
11
Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis
... increases tumor initiation by induction of chromosomal instability, but that initiated tumors need to reactivate telomerase for genome stabilization and tumor ...
7
Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges
... how tumor initiation and the early development remain ...the initiation of gastric cancers, and the tumor can ori- ginate from bone marrow derived cells ...
11
A cytokine mediated link between innate immunity, inflammation, and cancer
... microenvironment that is an indispensable participant in the neoplastic process. The mechanisms that link infection, innate immunity, inflammation, and cancer are being unraveled at a fast pace. Important components in ...
10
Cancer gene therapy using a survivin mutant adenovirus
... target tumor cell viability in vitro and in ...of tumor cells with pAd-T34A resulted in cytochrome c release from mitochondria, cleavage of approximately 46-kDa upstream caspase-9, processing of caspase-3 ...
11