tumor microenvironment (TME)
Exosomes in tumor microenvironment: novel transporters and biomarkers
... Tumor microenvironment (TME) plays an integral part in the biology of cancer, participating in tumor initiation, progression, and response to ...from tumor cells are called ...
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Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment
... TAMs: tumor-associated macrophages; TEXs: tumor-derived exosomes; TFEB: transcription factor EB; TGF- β : transforming growth factor- β ; TGN: trans-Golgi network; Th17: T helper cell 17; TLR2: Toll-like ...
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A Review of Exosomes and their Role in The Tumor Microenvironment and Host-Tumor "Macroenvironment"
... the tumor microenvironment (TME) and the hypothesis that exosomes may also generate a host-tumor “macroenvironment” beyond the TME through their miRNA and protein payloads, so to speak “fertilizing ...
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Immune mediators in the tumor microenvironment of prostate cancer
... the tumor is termed the tumor microenvironment ...the tumor originates ...the tumor. Immune cells can have both anti-tumor and pro-tumor activ- ...
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Theranostic Probes for Targeting Tumor Microenvironment: An Overview
... the tumor microenvironment ...promote tumor growth, invasion and ...enhancing tumor progression, it is vital to identify the different components in the ...
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Chemotherapy and tumor microenvironment of pancreatic cancer
... circulating tumor cells; CTLA-4: cytotoxic T-lymphocyte-associated protein 4; CXCL: c-x-c motif ligand; CXCR: receptor of c-x-c motif ligand; DAMPs: damage associated molecular patterns; DMBA: ...
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Osteoprotegerin rich tumor microenvironment: implications in breast cancer
... of tumor epithelial cells and stromal ...the tumor microenvironment components including immune cells, mesenchymal stem cells (MSCs), tumor associated fibroblasts (TAFs), fibroblasts, ...
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Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications
... entering tumor cells, the balance between positive and negative charges will be broken and thereby cause conformational changes, facilitating drug release in tumor ...of tumor microenvironment ...
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Social networks help to infer causality in the tumor microenvironment
... between tumor microenvironment components and predict their response to single and combined perturbations, and will serve to identify the most efficient treatment combina- tions that induce desired cell ...
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Effect of Stromal Cells in Tumor Microenvironment on Metastasis Initiation
... where tumor cells reside is called the tumor microenvironment (TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM), stromal cells, immune/inflammatory cells, ...
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Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment
... the tumor microenvironment suggests sev- eral alternative, though not mutually exclusive, hypoth- ...or tumor progression; another possibility is that these species are being enriched as the ...
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Immune targets in the tumor microenvironment treated by radiotherapy
... local tumor control with relatively less systematic side effects comparing to ...acquired tumor resistance leading to the risks of relapse and ...in tumor cells and stromal cells, especially the ...
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Novel Therapeutic Targets in the Brain Tumor Microenvironment
... brain tumor of adults and children, diffusely invades within the non-neoplastic ...the tumor and constituents of its microenvironment are known to regulate malignancy, and heparan sulfate ...
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Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis
... of tumor- derived SCF, inflammation, and germline Nf1 heterozygosity to neu- rofibroma development and provide insights for the design of future neurofibroma therapies in targeting its tumor ...
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Targeting the tumor microenvironment to enhance antitumor immune responses
... the tumor microenvironment ...of tumor-specific T cells by the peri- tumoral administration of CTLA-4-blocking antibodies in the lipid-based adjuvant montanide [213, ...approach, ...
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Molecular targeting of liposomal nanoparticles to tumor microenvironment
... target tumor microenvironments ranging from animal studies to clinics will be dependent on their ability to target all aspects of the tumor microenvironment, including cancer stem ...of tumor ...
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Tumor associated stromal cells as key contributors to the tumor microenvironment
... In addition to CAFs/TAFs, there is growing evidence to support a TASC subtype derived exclusively from adipose tissue called cancer-associated adipocytes (CAAs) [4] (Fig. 1). Found at the invasive front of tumors, CAAs ...
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A key role of GARP in the immune suppressive tumor microenvironment
... on tumor and T cells, we checked viability using 7-AAD (data not shown) and only viable cells were analyzed by flow ...inhibitory tumor microenvironment by decreasing GARP expression on melanoma ...
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Tissue factor in tumor microenvironment: a systematic review
... the tumor microenvironment ...the tumor microenvironment, resulting in an immunosuppressive milieu [82] (Figure ...the tumor microenvir- onment may cause local ischemia and hypoxia, ...
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Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment
... of tumor suppressor PTEN was closely associated with the lack of T cell infiltration as well as low PD-L1 expression in the tumor microenvironment of triple-negative breast cancer [30], indicating ...
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