tumor necrosis factor
Cachectin/Tumor Necrosis Factor
... particularly tumor necrosis factor released by macmphages under the influence of a malaria toxin Glycosyl phosphatidyl inositol (GPI) released at schizont rupture could be involved in enhancing ...
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Cellular Responses to Tumor Necrosis Factor
... Introduction Tumor necrosis factor α (TNF) is a proinflammatory cytokine produced mainly by activated macrophages or monocytes and plays an important role in diverse cellular events, such as the ...
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Characterization in vitro of a human tumor necrosis factor binding protein A soluble form of a tumor necrosis factor receptor
... J Clin Invest. 1990;86(5):1396-1402. https://doi.org/10.1172/JCI114853. Tumor necrosis factor (TNF) is a pleiotropic mediator of inflammatory responses. A cysteine-rich, highly glycosylated 30-kD ...
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Tumor necrosis factor inhibitors in psoriatic arthritis.
... human tumor necrosis factor alpha antibody, administered every four weeks as a subcutaneous injection in psoriatic arthritis: Twenty-four-week efficacy and safety results of a randomized, ...
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Tumor Necrosis Factor and Regulatory T Cells
... 2 BioMedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, Korea. CD4 + CD25 + FoxP3 + regulatory T (Treg) cells play major roles in the maintenance of ...
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Effect of Tumor Necrosis Factor on Body Systems
... Summary Tumor necrosis factor (TNF) is the prototypic member of a large cytokine family having two main types, tumor necrosis factor-alpha (TNF-α) and tumor ...
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The 55 kD tumor necrosis factor receptor on human keratinocytes is regulated by tumor necrosis factor alpha and by ultraviolet B radiation
... 55-kd tumor necrosis factor receptor is expressed by human keratinocytes and plays a pivotal role in regulation of human keratinocyte ICAM-I expression. Mechanisms of cutaneous inflammat[r] ...
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Tumor necrosis factor expression in human epithelial tumor cell lines
... Tumor necrosis factor (TNF) is a monokine with in vitro cytotoxicity for some but not all tumor ...epithelial tumor cell ...14 tumor cell lines has detectable levels of high ...
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Contribution of tumor necrosis factor alpha to the pathogenesis of stroke
... TNF-alpha stimulates release of three best- known beta chemokines — which can play a signif- icant role in inflammatory processes within the brain — i.e. macrophage inflammatory protein-1 alpha (MIP-1 alpha), macrophage ...
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The tumor necrosis factor receptor and human neutrophil function Deactivation and cross deactivation of tumor necrosis factor induced neutrophil responses by receptor down regulation
... regulation. B Schleiffenbaum, J Fehr J Clin Invest. 1990;86(1):184-195. https://doi.org/10.1172/JCI114683. Despite numerous reports, the role of tumor necrosis factor (TNF) in polymorphonuclear ...
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Prognostic serum tumor necrosis factor- in paediatric patients with sepsis
... Bacteremia and endotoxemia elicit the production of a cascade of endogenous mediators that cause a metabolic and immunologic host systemic inflammatory response. Both gram-negative and gram-positive bacteria, as well as ...
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TUMOR NECROSIS FACTOR ALPHA AND INTERLEUKIN 6 IN ESSENTIAL HYPERTENSION
... of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) which might play an important role in the initiation and progression of hypertension by a variety of mechanisms such as giving rise to ...
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Systemic use of tumor necrosis factor alpha as an anticancer agent
... Tumor necrosis factor-α (TNF-α) has been discussed as a potential anticancer agent for many years, however initial enthusiasm about its clinical use as a systemic agent was curbed due to significant ...
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The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia
... Tumor necrosis factor (TNF) is a protein hormone implicated in the development of septic shock and other pathologic states. However, complexities inherent in detecting TNF synthesis by individual ...
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The role of tumor necrosis factor alpha in systemic lupus erythematosus
... (a) tumor necrosis factor (TNF) expression was low and TNF administration helpful or (b) TNF was high and TNF blockade of therapeutic benefit, depen- ding on the mouse model ...
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Anti-Tumor Necrosis Factor- Induced Systemic Lupus Erythematosus
... Patients on anti-TNF- therapy may develop systemic features of SLE, which usually resolve after discontinuation of the offending drug. The associated general features include constitutional symptoms of fever, malaise, ...
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Epstein-Barr Virus Immediate-Early Protein BZLF1 Inhibits Tumor Necrosis Factor Alpha-Induced Signaling and Apoptosis by Downregulating Tumor Necrosis Factor Receptor 1
... Tumor necrosis factor alpha (TNF- ␣ ) is a key mediator of host immune and inflammatory responses and inhibits herpesvirus replication by cytolytic and noncytolytic ...
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The Oncogene Metadherin Modulates the Apoptotic Pathway Based on the Tumor Necrosis Factor Superfamily Member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in Breast Cancer.
... Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) 3 is a member of the TNF super family that can initiate apoptosis via activation of the extrinsic apoptosis pathway (1, ...
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CrmE, a Novel Soluble Tumor Necrosis Factor Receptor Encoded by Poxviruses
... Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom Received 2 August 2000/Accepted 29 September 2000 Cytokines and chemokines play a critical role in both the innate ...
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C/EBP beta regulation of the tumor necrosis factor alpha gene
... proteinases. Tumor necrosis factor alpha (TNF alpha) is particularly important in this process because of its ability to regulate other inflammatory mediators in an autocrine and paracrine ...
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