tumor necrosis factor alpha (TNF-alpha)
Tumor Necrosis Factor-alpha (-308 G/A) is a Predictor for Development of Gestational Diabetes Mellitus in Saudi Pregnant Women
... circulating TNF-α by in vivo injection of soluble TNF-α receptor- immunoglobulin G chimeric protein leads to a considerable making greater in insulin sensitivity [6], and infusion of TNF-α during ...
11
Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice.
... These classes of inflammatory cells produce an assortment of cytokines, such as tumor necrosis factor alpha TNF-a, alpha interferon IFN-ot, gamma interferon IFN-y, interleukin-1 alpha IL[r] ...
6
The effect of the pro inflammatory cytokine tumor necrosis factor alpha on human joint capsule myofibroblasts
... 7 Tumor necrosis factor-alpha (TNF-α) modulates the synthesis of prostaglandin E 2 (PGE 2 ) in alpha-smooth muscle actin (α-SMA)- positive myofibroblasts ...upon TNF-α ...
16
Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin 25 Mediated Protection from Amebic Colitis
... that tumor necrosis factor alpha (TNF- ␣ ) production was associated with increased risk of ...of TNF- ␣ ...colonic TNF- ␣ ...of TNF- ␣ resulted in resistance to ...
10
Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria
... Tumor necrosis factor alpha (TNF-α) plays a central role in inflammatory processes, immune regulation and ...apoptosis. TNF-α exerts its action via cell-surface ...to ...
9
Functional switching of macrophage responses to tumor necrosis factor alpha (TNF alpha) by interferons Implications for the pleiotropic activities of TNF alpha
... of TNF alpha in stimulating the synthesis of two macrophage gene products, namely IGF-1, a growth factor implicated in wound repair and fibrosis, and complement component factor B (Bf), an ...
10
Treatment with recombinant human tumor necrosis factor alpha protects rats against the lethality, hypotension, and hypothermia of gram negative sepsis
... of TNF are not reproducibly measurable in rats following ...human TNF-alpha (100 micrograms/kg) to rats undergoing CLP 1 d after the treatment period resulted in a significant reduction in mortality ...
7
Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke
... serum TNF-α level was asso- ciated with higher risk of ischemic stroke in the Chinese Han ...the TNF-α was not asso- ciated with risk of stroke in a British prospective study ...that TNF-α was linked ...
11
Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha Downregulating Genes for the Development of Antituberculous Vaccines
... reduced TNF production of infected C10, we reasoned that the respective ...such TNF-upregulating mutants could exhibit en- hanced immunogenicity, we chose to focus on the two genes encoding triacylglycerol ...
15
Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF alpha receptor subtype 1 and require TNF alpha receptor subtype 2
... prothrombotic TNF a effects, including an enhanced endothelial production of reactive oxygen species; upregulation of p-selectin, tissue factor, and PAI-1 expression; and suppression of throm- ...bomodulin. ...
13
Pro-inflammatory activity of Astronium fraxinifolium Schott on Lipopolysaccharide-stimulated RAW 264.7 cells
... (NO), tumor necrosis factor alpha (TNF-α), and transforming growth factor beta (TGF-β) levels were determined in supernatants from LPS-stimulated RAW ...of TNF-α and low ...
7
Original Article Oral administration of Lactobacillus acidophilus stain SW1 suppresses tumor necrosis factor (TNF)-alpha and increases transforming growth factor (TGF)-beta in mice
... inhibit TNF-α production by prevent- ing the activation of c-Jun and the mitogen-acti- vated protein kinase (MAPK)-regulated tran- scription factor activator protein (AP)-1 in mam- mals ...inhibited ...
6
Journal of Applied Pharmaceutical Science
... of tumor necrosis factor alpha (TNF-α), as a marker of inflammation, malondialdehyde (MDA), as a marker of lipid peroxidation, and levels of Lactate dehydrogenase (LDH) and creatine ...
5
Safety of biologics in rheumatoid arthritis: data from randomized controlled trials and registries
... Abstract: Over the past decade, the use of biologics has significantly changed the management of rheumatoid arthritis (RA). Biologics selectively target components of the immune system, result- ing in better disease ...
6
Functional Analysis of a Human Tumor Necrosis Factor α (TNF-α) Promoter Polymorphism Related to Joint Damage in Rheumatoid Arthritis
... (1997) Scarring trachoma is associated with polymor- phism in the tumor necrosis factor alpha (TNF-a) gene promoter and with elevated TNF-a levels in tear fluid. Grove J, Daly AK, Bassen[r] ...
10
Original Article The single nucleotide polymorphisms in TNF-α promoter are associated with susceptibility and clinical features of pulmonary tuberculosis in Chinese Uygurs
... The tumor necrosis factor alpha (TNF-α) that is involved in the interactions between the pathogens and host immune systems is highly related to TB susceptibility and diversity in ...
10
Herb-partitioned moxibustion upregulated the expression of colonic epithelial tight junction-related proteins in Crohn’s disease model rats
... junction; TNF-α: tumor necrosis factor-alpha; TNFR1: tumor necrosis factor receptor-1; ZO-1: zonula occludens proteins-1; UC: ulcerative colitis; ECCO: European ...
10
Early gestational mesenchymal stem cell secretome attenuates experimental bronchopulmonary dysplasia in part via exosome-associated factor TSG-6
... microscopy; TNF- α : Tumor necrosis factor alpha; TSG-6: Tumor necrosis factor alpha-stimulated gene-6; TSG-6 siRNA: Tumor necrosis ...
26
Estrogen modulates the influence of cardiac inflammatory cells on function of cardiac fibroblasts
... if tumor necrosis factor-alpha (TNF-α) produced by inflam- matory cells represents a mechanism contributing to the stimulatory effects of inflammatory cells on cardiac fibroblasts, ...
10
Effect of Tumor Necrosis Factor on Body Systems
... Tumor necrosis factor (TNF) is the prototypic member of a large cytokine family having two main types, tumor necrosis factor-alpha (TNF-α) and tumor ...
15