tumor suppressor
Tumor suppressor and overgrowth suppressor genes of Drosophila melanogaster: developmental aspects
... Int I De" BinI 38 565 590 (]99 \] 565 Rfview Tumor suppressor and overgrowth suppressor genes of Drosophila melanogaster Developmental aspects ELISABETH GATEFF* Institut fur Genetik, Johannes Gutenber[.] ...
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A neuronal function of the tumor suppressor protein merlin
... The hereditary disease Neurofibromatosis type 2 Mutations in the NF2 gene are causative for the autosomal- dominant disease Neurofibromatosis Type 2 (NF2). This rare multiple neoplasia syndrome affects about 1 in 25,000 ...
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SOX17 is a tumor suppressor in endometrial cancer
... In this study, we evaluated SOX17 expression in EC patient tumor samples and cell lines. High SOX17 levels were observed in benign endometrial tumor tissues, with low expression in malignant EC tissues. As ...
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MTG16 is a tumor suppressor in colitis-associated carcinoma
... a tumor suppressor in inflammatory ...the tumor microenvironment, all of which influence tumor growth and ...a tumor suppressor in a diverse spectrum of epithelium- based ...
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CBX7 is a tumor suppressor in mice and humans
... The CBX7 gene encodes a polycomb group protein that is known to be downregulated in many types of human cancers, although the role of this protein in carcinogenesis remains unclear. To shed light on this issue, we ...
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Evidence for a Tumor Suppressor Role for the Large Tumor Suppressor Genes LATS1 and LATS2 in Human Cancer
... Genetic analysis of Lats/Wts family genes using Drosoph- ila and mice models has revealed their role as a negative growth regulator and tumor suppressor (Justice et al. 1995; Xu et al. 1995; St John et al. ...
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Activation of tumor suppressor protein PP2A inhibits KRAS driven tumor growth
... in substantial tumor-growth inhibition compared with vehi- cle control. Furthermore, mutation of residues at the putative drug-binding site completely abrogated the antitumorigenic effect of SMAP. These results ...
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HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability
... In the current work, we focus on integration sites analysis of HPV16, the most common type of HPV in Shanghai, try- ing to understand the HPV16 integration characteristics and the potential consequence of viral fragment ...
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New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
... the tumor suppressor p53 ( p53 or Trp53 ) ...ideal tumor associated antigen (TAA) for cancer ...to tumor regression and clearance, which were at least partially caused by the activation of ...
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Tumor suppressor in oral carcinogenesis
... The head and neck squamous epithelium (HNSE), with basal layers containing stem cells and progenitors to gradually differentiated squamous cells, represents the paradigm of stratified epithelium which is consistently ...
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SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
... a tumor promoter came from experiments showing that SIRT1 physi- cally interacts with p53 and attenuates p53-mediated functions through deacetylation of p53 at its C-terminal Lys382 residue [12, ...many ...
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The regulation of cellular metabolism by tumor suppressor p53
... induces glutamine transporters SLC38A5 and SLC1A5 to promote glutamine uptake in cells. Furthermore, Myc induces the expression of glutaminase 1 (GLS1), an en- zyme that converts glutamine into glutamate as the first ...
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BRCA1 tumor suppressor network: focusing on its tail
... Germline mutations of the BRCA1 tumor suppressor gene are a major cause of familial breast and ovarian cancer [1,2]. BRCA1 plays critical roles in a number of diverse cellular processes that ensure genome ...
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Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment
... of tumor-promoting ...several tumor-promot- ing genes in the upregulated group and tumor-suppressive genes in the downregulated group by reverse transcription quantita- tive PCR (RT-qPCR) and Western ...
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DYRK1A in Down syndrome: an oncogene or tumor suppressor?
... report their loss- and gain-of-function experiments in mouse and human cells that show that increased expression of the kinase encoded by the chromosome 21 gene DYRK1A suppresses the nuc[r] ...
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SETD2: an epigenetic modifier with tumor suppressor functionality
... SETD2 is responsible for the trimethylation of H3K36 in the gene body of actively transcribed genes and its inactivation interferes with the function of readers of this specific histone modification. The role of H3K36me3 ...
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TGF β antagonists: Why suppress a tumor suppressor?
... Small-molecule inhibitors of TGF-β action could also be of value and should offer better drug speci- ficity than the fusion protein described here. Their design will depend on a greater understanding of the cross-talk ...
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A Secreted Tumor-Suppressor, mac25, with Activin-Binding Activity
... ture medium and suppressed the growth of various tumor cells lines, in addition to an osteosarcoma cell line. Thus, mac25 may be a general growth-suppressor. The viability of Saos-2 cells and HeLa cells was ...
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Immunohistochemical Evaluation of Human p53 Tumor Suppressor Protein Content in Ductal Carcinoma in Situ of the Breast
... Source of tissue. Samples were acquired from women that had surgical removal of breast tumor/lumps for pathologic evaluation at St. Lawrence Local Hospital in E-Lansing (Michigan, USA). These samples were ...
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Original Article Investigating RASSF1A hypermethylation and endometrial carcinoma occurrence and development using in vivo and in vitro demethylation of 5-AZA-2’-deoxy cytidine
... inducing tumor cells apoptosis may not only restore the function of the tumor suppressor gene RASSF1A, but could also involve other mechanisms [38, ...
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