Tumor Suppressor Protein
The function, regulation and therapeutic implications of the tumor suppressor protein, PML
... The tumor suppressor protein, promyelocytic leukemia protein (PML), was originally identified in acute promyelocytic leukemia due to a chromosomal translocation between chromosomes 15 and ...
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Cell-Specific Modulation of Papovavirus Replication by Tumor Suppressor Protein p53
... In vitro replication studies have shown that papillomaviruses and Py resemble each other in their utilization of a number of cellular replication factors, including DNA polymerase ␣/pri- mase, DNA polymerase ␦, RPA, ...
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Activation of tumor suppressor protein PP2A inhibits KRAS driven tumor growth
... in substantial tumor-growth inhibition compared with vehi- cle control. Furthermore, mutation of residues at the putative drug-binding site completely abrogated the antitumorigenic effect of SMAP. These results ...
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The Coronavirus Endoribonuclease Nsp15 Interacts with Retinoblastoma Tumor Suppressor Protein
... retinoblastoma protein (pRb) ...the protein surface ...Nsp15 protein and in proteins of other ...Nsp15 protein was from the Urbani isolate (GenBank accession ...
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Complex formation between the lymphotropic papovavirus large tumor antigen and the tumor suppressor protein p53.
... 5417-5424 0022-538X/91/105417-08$02.00/0 Copyright © 1991, American Society for Microbiology Complex Formation between the Lymphotropic Papovavirus Large Tumor Antigen and the Tumor Supp[r] ...
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The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein
... sAC protein expression, we examined data from the Human Protein Atlas ...Human Protein Atlas confirmed that in most human cancers where sAC expression was diminished, sAC protein level is ...
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Immunohistochemical Evaluation of Human p53 Tumor Suppressor Protein Content in Ductal Carcinoma in Situ of the Breast
... Fig 1. Detection of mutant p53 protein accumulation by immunohistochemistry. (1) p53 immunopositivity in colon tissue section. This section of tissue was stained using avidin-biotin immunoperoxidase staining ...
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A neuronal function of the tumor suppressor protein merlin
... GTPase proteins are molecular switches that regulate many important processes in the cell, including the organization of the actin cytoskeleton [24]. By provoking local actin re- arrangements, the protein family ...
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von Hippel–Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia inducible factor 2α signaling and splenic erythropoiesis
... (VHL) tumor suppressor protein (pVHL) is unique in that it is not associated with tumor development, but rather with Chuvash polycythemia, a heritable disease char- acterized by elevated ...
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A Genetic Screen for Dominant Modifiers of a cyclin E Hypomorphic Mutation Identifies Novel Regulators of S-Phase Entry in Drosophila
... the tumor suppressor protein, Retinoblastoma is controlled by the activity of the Cyclin-dependent ser/ (Rb; Lundberg and Weinberg 1998), which functions thr protein kinases (Cdks) associated ...
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Bromodomain-containing protein 7 (BRD7) as a potential tumor suppressor in hepatocellular carcinoma
... Bromodomain-containing protein 7 (BRD7) is a subunit of the PBAF complex, which functions as a transcriptional cofactor for the tumor suppressor protein ...its tumor suppressive effect ...
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Two Distinct Activities Contribute to the Oncogenic Potential of the Adenovirus Type 5 E4orf6 Protein
... the tumor suppressor ...the tumor suppressor ...the tumor suppressor protein (36, 45, ...with tumor growth rates in nude mice, indicating a relationship between p53 ...
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LKB1 and AMPK and the cancer-metabolism link - ten years after
... a tumor suppressor that normally restrains growth and proliferation of cancer cells as well as the associated metabolic changes, one would expect such cells to be under selective pressure to down-regulate ...
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Mapsin Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma
... a tumor-suppressor ...maspin protein has the ability to induce upregulation of some specific integrin levels, resulting in suppression of an invasive phenotype of the breast cancer cell ...against ...
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Effectiveness of a Computer Based Syntax Program in Improving the Morphosyntax of Students Who are Deaf/Hard of Hearing
... Cyclin Dependent Kinases (CDKs) play important roles in regulating the entry from interphase to mitosis. For cells to exit from mitosis, CDKs must be degraded or be dephosphorylated to inhibit their functions. How cells ...
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The neuronal RNA binding protein HuB as a potential tumor suppressor in glioblastoma
... We then looked for suitable cell models to investigate the effects of the HuB protein in a CDKN2A null glioma background. We initially employed U87MG cells, a commonly used glioma cell line, and we genotyped it ...
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SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
... in tumor promotion or ...many tumor sup- pressor genes, including DBC1, HIC1, and p53, which may regulate SIRT1 through ...and tumor formation, suggesting a possibility to extend lifespan and inhibit ...
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Therapeutic Potential of Neem Synthesized Silver Nanoparticles on Human Gastric Cancer Cells in Vitro
... generate protein radicals [59], initiation of lipid peroxidation [60]-[62], DNA-strand breaks, modification to nucleic acids [63], modulation of gene expression through activation of re- dox-sensitive ...
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RETINOBLASTOMA RELATED PROTEIN controls the transition to autotrophic plant development
... like tumor tissue: sugar-transporters were upregulated in combination with highly increased sucrose accumulation, photosynthetic capacity and expression of genes of the photosynthesis machinery was reduced, and ...
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Cellular Reproduction
... When tumor suppressor genes don't work properly, cells can grow out of control. – More than 50% of tumors contain a mutation in the tumor suppressor gene p53..[r] ...
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