Tumor suppressor PTEN
Original Article miR-106b promoted growth and inhibited apoptosis of nasopharyngeal carcinoma cells by suppressing the tumor suppressor PTEN
... in tumor tissues and lymph node metastasis NPC ...human tumor suppressor PTEN, modulating PI3K/Akt signaling, which are responsible for cell proliferation and ...
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In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself
... processing PTEN generates a number of splice ...frame. PTEN-B, SV-5a, SV-5b and SV-5c contain parts of in- tron 5 and SV-3a, SV-3b and SV-3c contain parts of in- tron ...variant PTEN-Δ results from ...
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Original Article MicroRNA-590-5p promotes cell survival in endometrioid endometrial cancer by suppressing tumor suppressor PTEN
... 48 h after transfection, total protein of cultured cells was extracted using RIPA buffer with pro- tease inhibitor Cocktail (Pierce, Rockford, IL, USA). BCA protein assay kit (Beyotime, Haimen, China) was used to detect ...
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Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau
... that PTEN affects phosphor- ylation of wild-type tau at multiple ...that PTEN affects the mutant tau most significantly at the Akt ...null PTEN, resembling the in vivo ...
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Effectiveness of a Computer Based Syntax Program in Improving the Morphosyntax of Students Who are Deaf/Hard of Hearing
... of Akt promotes its survival capability by inceasing glycolysis levels. Akt regulates glycolysis though many aspects. Firstly, the activated Akt pathway in respiration deficient cancer cells increases glucose consumption ...
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<p>Deficiency of <em>PTEN</em> and <em>CDKN2A</em> Tumor-Suppressor Genes in Conventional and Chondroid Chordomas: Molecular Characteristics and Clinical Relevance</p>
... The tumor-suppressor PTEN was fi rst identi fi ed in 1997, 39 and it has been found to be a negative regulator of the phosphatidylinositol-3-kinase (PI3K)/AKT/mTOR sig- naling ...40 PTEN ...
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Role of Rho GTPases and PTEN in the migration of human glioma cells
... Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways, J Cell Biol 143,1375-83. Proliferation[r] ...
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Original Article Silencing of DJ-1 reduces proliferation, invasion, and migration of papillary thyroid cancer cells in vitro, probably by increase of PTEN expression
... the tumor suppressor PTEN [18], it was assumed that DJ-1 suppressed cell prolifera- tion, migration, and invasion by regulating ...of PTEN in DJ-1 knocked-down cells were determined by qRT-PCR ...
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Original Article Expression of miR-3182 and EBV-miR-BART8-3p in nasopharyngeal carcinoma is correlated with distant metastasis
... causes tumor metastasis in ...cellular tumor suppressor PTEN. Reduction of the PTEN dos- age by EBV-miR-BART1 activates PTEN-de- pendent pathways including PI3K-Akt, FAK- p130 ...
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Coadministration of doxorubicin and etoposide loaded in camel milk phospholipids liposomes showed increased antitumor activity in a murine model
... model. Tumor-bearing mice treated with a combination of Dox and ETP loaded into CML-Lip showed increased survival and reduced tumor growth compared to other groups, including the combination of Dox and ETP ...
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Studies of the PTEN tumour suppressor in endometrial cancer
... PVDF membranes which had been electroblotted were pre-wet with methanol for a few seconds, then washed 3 times with T/P-BST, (Appendix II), for 5 minutes per wash. A s ufficient volume of buffer was used to completely ...
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DNA Methylation profiles as predictors of recurrence in non muscle invasive bladder cancer: an MS-MLPA approach
... HIC1 is a new candidate tumor suppressor gene [23], but the relevance of its methylation in bladder cancer prognosis is still unknown. Although GSTP1 methy- lation is a well known event in the ...
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USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer
... 9]. PTEN is located at 10q23, which is one of the most frequently mutated genes in human cancers [10, ...11]. PTEN deficiency has been identified in a PTEN-deficient mice ...Besides, PTEN ...
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Role of Pten in leukemia stem cells
... regulators, Pten was also downregulated ...the Pten downregu- lation [34]. However, the mechanisms of Pten regulation of LSC function in CML need to be ...when Pten was overexpressed [27], ...
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Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells
... [5] reported that DNMT3b deletion in a colorectal can- cer cell line reduced global DNA methylation by less than 3%, but co-silencing of both DNMT1 and DNMT3b nearly eliminated methyltransferase activity, and reduced ...
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<p>USP13 serves as a tumor suppressor via the PTEN/AKT pathway in oral squamous cell carcinoma</p>
... Abcam), PTEN (#9552, Cell Signaling Technology, Danvers, MA, USA), p-AKT (#9271, Cell Signaling Technology), AKT (#9272, Cell Signaling Technology), and glyceraldehyde- 3-phosphate dehydrogenase (#5174, Cell ...
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Original Article FOXA1 positively regulates gene expression by changing gene methylation status in human breast cancer MCF-7 cells
... of tumor suppressor genes (DAPK, MGMT, p53, RASSF1A) promotor in our estab- lished siRNA-FOXA1 and FOXA1 over-expres- sion cells as well as control cell using quantita- tive methylation specific real-time ...
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SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
... a tumor suppressor or promoter, it is important to identify endogenous genes or small chemicals that inhibit or activate ...inhibit tumor growth ...
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... of tumor suppressor genes as well as their relation with microsatellite ... tumor samples and samples of the surrounding healthy tissue of patients with colorectal ...of tumor samples. ...
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Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples
... in tumor size with the first cycle of therapy and change in IHC scores for all four tumor suppressor genes could be assessed in 15 ...immediate tumor growth, while five patients had a ...
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