Tumor therapy
Current applications and future prospects of nanomaterials in tumor therapy
... of tumor therapies is a multidisciplinary field, and with more in-depth research on tumor biology, tumor immunology, molecular biology, and NMs, an ideal therapy or NM will eventually be ...
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Nanomedicine engulfed by macrophages for targeted tumor therapy
... into tumor tissues, are a novel drug vehicle for directional drug ...the tumor site hypersecreting chemokine in immunocompetent mice in comparison to the tumor site secreting low levels of chemokine ...
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<p>Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy</p>
... or therapy methods are involved, the more complicated the nanoparticle becomes and the more difficult for researchers to coordinate each ...cancer therapy. To build more robust multifunctional hypoxia ...
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Mathematical Modeling and Analysis of Tumor Therapy with Oncolytic Virus
... increased antibody could deactivate viruses before the tumor has been destroyed. This can be overcome by us- ing parental viruses that are not normal human pathogens, thereby avoiding any pre-existing immunity. ...
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Photodynamic Tumor Therapy: Mitochondrial Benzodiazepine Receptors as a Therapeutic Target
... (1990) Peripheral- type benzodiazepine receptors mediate transloca- tion of cholesterol from outer to inner mitochon- drial membranes in adrenocortical cells. (1988) Involvement of the[r] ...
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Three-dimensional tumor spheroids for in vitro analysis of bacteria as gene delivery vectors in tumor therapy
... for tumor targeting strategies are spore-forming Clostridium ...as tumor therapeutics based on their oncolytic activity (reviewed in [14, ...areas, tumor regres- sion was incomplete and experimental ...
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Histone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy
... on tumor cells in vitro and in in vivo model of ...the tumor should improve their clinical benefit by limiting systemic toxicity and by increasing the anti-tumor ...the tumor in vivo and ...
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Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy
... has been shown to be an effective strategy to promote effi- cacy between therapeutic agents, as indicated by the recent approval of Vyxeos (Dublin, Ireland) (liposomes coloaded with daunorubicin and cytarabine at a fixed ...
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Optimization of the tumor microenvironment and nanomedicine properties simultaneously to improve tumor therapy
... the tumor tissues than its counterpart control group, even those regions far away from tumor ...near tumor vessels ...most tumor vessels that did not ...in tumor perfusion than the ...
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Taking aim at translation for tumor therapy
... The use of eIF4E ASOs was previously shown to have the predicted effect of reversing transformation (11, 12). Howev- er, this strategy was not generally effective due to the difficulties of using ASOs thera- peutically. ...
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Survivin: a unique target for tumor therapy
... against tumor cells, therefore antigen delivery and role of adjuvants is important to enhance immunogenicity of this protein Furthermore, both CD4 and CD8 restricted epitopes from Survivin protein are important ...
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Tumor biology and cancer therapy – an evolving relationship
... in tumor therapy and tumor biology is ...cancer therapy by highlighting exemplary results from recent clinical trials with colorectal and pancreatic cancer patients and to discuss the current ...
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Photothermal therapy of melanoma tumor using multiwalled carbon nanotubes
... on tumor was shaved and the skin was cleansed. Tumor sizes were measured using a caliper and evaluated with an ultrasonography machine (Ultrasonix SonixOP; Burnaby, BC, Canada) before the treatment and 3 ...
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Precision medicine becomes reality—tumor type-agnostic therapy
... the tumor originated, and therefore established a precedent for tumor type-agnostic ...15 tumor types with MSI-H/dMMR and 75% ORR for larotrectinib across more than 12 tumor types with ...
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Apatinib for molecular targeted therapy in tumor
... study, 46 patients with advanced cancer were enrolled, including 34 cases of gastrointestinal cancer, three cases of lung cancer, three cases of breast cancer, and six cases of other tumor types. The maximum ...
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Roscovitine confers tumor suppressive effect on therapy resistant breast tumor cells
... tamoxifen therapy resistance by activating CDK2 func- tions ...hormone therapy resistance ...of therapy-resistant breast cancer cells and to down regulate expression of ER a ...hormonal ...
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<p>Tumor Targeting Chemo- and Photodynamic Therapy Packaged in Albumin for Enhanced Anti-Tumor Efficacy</p>
... The tumor accumulation of nanomedicines was mainly based on the EPR ...in tumor vasculature as well as binding of SPARC (secreted protein, acidic and rich in cysteine), an extracellular matrix glyco- ...
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Solid Tumor Differentiation Therapy – Is It Possible?
... Similar to other solid tumors, sarcomas have been historically classified based on histopathological features reflecting the degree to which these tumors resemble normal tissue. However, unlike other solid tumors, the ...
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Tumor refractoriness to anti-VEGF therapy
... Anti-angiogenic refractory tumors contained blood vessels with a investment of pericytes expressing alpha smooth muscle actin (α-SMA) [20]. Pericyte coverage promote resistance through direct support or paracrine ...
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Tumor-specific activated photodynamic therapy with an oxidation-regulated strategy for enhancing anti-tumor efficacy
... ROS generation [35]. If intracellular redox homeostasis is disrupted, an increase in ROS production may occur. To verify this hypothesis, we measured GSH depletion and ROS elevation. To do this, we used NEM as a GSH ...
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