Tumour necrosis factor
Commercially Available Antibodies to Human Tumour Necrosis Factor-α Tested for Cross-Reactivity with Ovine and Bovine Tumour Necrosis Factor-α using Flow Cytometric Assays
... human tumour necrosis factor- α tested for cross-reactivity with ovine and bovine tumour necrosis factor- α using flow cytometric ...treatments. Tumour necrosis ...
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Tumour necrosis factor signalling in health and disease
... of tumour necrosis factor (TNF): TNF receptor 1/2 (TNFR1/2) signalling ...IIb), necrosis (via complex IIc), or cell survival (via complex ...nuclear factor-kappa B (NF-κB) and AP1 ...
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The effect of tumour necrosis factor-alpha and insulin on equine digital blood vessel function in vitro
... In other species, vascular and endothelial dysfunction can be caused by hyperinsulinaemia and/or insulin resistance (IR) [12] and inflammatory mediators [13]. Normally, insulin activates both the phosphatidylinositol ...
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Redefining the role of tumour necrosis factor in macrophage differentiation and effector function in bacterial and tumour defences
... Tumour necrosis factor (TNF) is an essential pro-inflammatory cytokine predominantly secreted by macrophages that regulates the inflammatory response to ...a tumour model and we hypothesized ...
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Immune complexes from rheumatoid arthritis synovial fluid induce FcγRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor α by peripheral blood mononuclear cells
... ICs communicate with macrophages via Fcγ receptors, which results in phagocytosis, degranulation, transcription of cytokine genes and release of inflammatory mediators. Fcγ receptors have been shown to be important in ...
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Tumour necrosis factor - alpha mediated mechanisms of cognitive dysfunction
... Mental and neurological disorders like schizophrenia and depression constitute 13% of the global disease burden, quickly surpassing the threat by cardiovascular disorders and cancer [1]. A common link between ...
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Induction maintenance with tumour necrosis factor inhibitor combination therapy with discontinuation versus methotrexate monotherapy in early rheumatoid arthritis: a systematic review and meta analysis of efficacy in randomised controlled trials
... introduction of biological disease-modifying drugs (bDMARDs) such as tumour necrosis factor inhibitors (TNFi). 1 2 There are currently fi ve approved TNFi (adali- mumab (ADA), etanercept, in fl iximab ...
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Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin 6 in bone infection
... osteoblast tumour necrosis factor receptor-1 (TNFR-1) is responsible for the recognition of and binding to ...nuclear factor kappa B ...
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The risk of acute coronary syndrome in rheumatoid arthritis in relation to tumour necrosis factor inhibitors and the risk in the general population: a national cohort study
... ACS, Acute coronary syndrome; HR, Hazard ratio; RA, Rheumatoid arthritis; TNFi, Tumour necrosis factor inhibitor. b Adjusted for age, sex and county of residence. c Adjusted for sex; age; county of ...
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Genetic polymorphisms in tumour necrosis factor receptors (TNFRSF1A/1B) illustrate differential treatment response to TNFα inhibitors in patients with Crohn’s disease
... Figure 1 Gene expression level of TNFα, TNFRSF1A and TNFRSF1B according to each allele type in selected single nucleotide polymorphisms (SNP) (A–I) among patients with Crohn’s disease (CD) (n=54) and healthy controls ...
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Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis
... soluble tumour necrosis factor receptors (sTNFRs) are elevated in the circulation of patients with rheumatoid arthritis ...of tumour necrosis factor- α , levels of sTNFRs in RA ...
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Discontinuation and switching patterns of tumour necrosis factor inhibitors (TNFis) in TNFi naive and TNFi experienced patients with psoriatic arthritis: an observational study from the US based Corrona registry
... Figure 3 Provider-reported reasons for discontinuation or switch of the index TNFi in (A) the overall population and (B) patients who discontinued by the first follow-up visit. Potential reasons for discontinuation or ...
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Inhibition of anti tuberculosis T lymphocyte function with tumour necrosis factor antagonists
... Tumour necrosis factor (TNF) antagonists such as the anti- TNF monoclonal antibodies (mAbs) infliximab (Ifx) and adali- mumab (Ada) and the soluble TNF receptor etanercept (Eta) are efficacious in ...
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Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen induced arthritis in combination with tumour necrosis factor blockade
... The antagonist RB200 has been developed to target all four members of the EGFR family. RB200 is composed of the ECD of HER1/ErbB1 (amino acids 1 to 621) and HER3/ErbB3 (amino acids 1 to 621), fused with the Fc domain of ...
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Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee
... Secondary endpoints included change in the WOMAC pain subscale score, WOMAC pain subscale 20% and 50% improvement, change in the WOMAC stiffness and function subscales, change in the pat[r] ...
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The effect of oxygen tension on the cytotoxic action of tumour necrosis factor-alpha
... of tumour blood flow (TBF), tissue accumulation of neutrophils (Yi and Ulich, 1992), and an early influx of red cells into the tumour (MacPherson and North, 1986; Shimomura et a l 1988; Kallinowski et a l ...
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Tumour necrosis factor-α production in fibrosing alveolitis is macrophage subset specific
... AM = alveolar macrophage; APAAP = alkaline phosphatase/antialkaline phosphatase; BAL = bronchoalveolar lavage; CFA = cryptogenic fibrosing alveolitis; FA = fibrosing alveolitis; FASSc = [r] ...
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Age-related loss of CpG methylation in the tumour necrosis factor promoter
... performed using a mixed effects model in which we included the intra-individual correlations between the methylation levels at the CpG sites. When considering the change in methylation with age, this variable was entered ...
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Exogenous tumour necrosis factor α induces suppression of autoimmune arthritis
... Results Arthritic LEW rats show highest levels of TNFα at the recovery phase of AA, whereas AA-resistant WKY rats exhibit an opposite profile The results of ex vivo TNFα secretion cytoki[r] ...
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Effects of tumour necrosis factor on BrdU incorporation in cultured human enterocytes
... TNFot induced DNA synthesis in confluent 140 7 and L929 cells: The MTT assay, which relates to the number of viable cells, showed no significant difference in cell density of the 1407 ce[r] ...
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