Tumour necrosis factor-a
Commercially Available Antibodies to Human Tumour Necrosis Factor-α Tested for Cross-Reactivity with Ovine and Bovine Tumour Necrosis Factor-α using Flow Cytometric Assays
... human tumour necrosis factor- α tested for cross-reactivity with ovine and bovine tumour necrosis factor- α using flow cytometric ...treatments. Tumour necrosis ...
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Cost effectiveness of abatacept, rituximab, and TNFi treatment after previous failure with TNFi treatment in rheumatoid arthritis: a pragmatic multi centre randomised trial
... Introduction: For patients with rheumatoid arthritis (RA) whose treatment with a tumour necrosis factor inhibitor (TNFi) is failing, several biological treatment options are available. Often, another ...
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The effect of oxygen tension on the cytotoxic action of tumour necrosis factor-alpha
... of tumour blood flow (TBF), tissue accumulation of neutrophils (Yi and Ulich, 1992), and an early influx of red cells into the tumour (MacPherson and North, 1986; Shimomura et a l 1988; Kallinowski et a l ...
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Induction maintenance with tumour necrosis factor inhibitor combination therapy with discontinuation versus methotrexate monotherapy in early rheumatoid arthritis: a systematic review and meta analysis of efficacy in randomised controlled trials
... tumor necrosis factor α , monoclonal antibody, biological product, limited to clinical trials in humans (see online supplementary table S1 for detailed ...
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Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin 6 in bone infection
... osteoblast TNFR-1 induces activation of NFkB. Either deleting SpA from S. aureus or reducing TNFR-1 expression by osteoblasts prevented activation of NFkB. This is an important observation, as NFkB is a critical ...
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Redefining the role of tumour necrosis factor in macrophage differentiation and effector function in bacterial and tumour defences
... Tumour necrosis factor (TNF) is an essential pro-inflammatory cytokine predominantly secreted by macrophages that regulates the inflammatory response to ...a tumour model and we hypothesized ...
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Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen induced arthritis in combination with tumour necrosis factor blockade
... investigated previously in other in vivo models. RB200 inhibited EGF- and NRG1-b1-stimulated tyrosine phosphorylation of HER1, HER2 and HER3 and also showed potency in cell proliferation assays [18]. In addition, RB200 ...
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Effectiveness and safety of TNF inhibitors in adults with juvenile idiopathic arthritis
... Introduction: Many children with juvenile idiopathic arthritis ( JIA) continue to have active disease into adulthood. Adults with JIA are a heterogeneous group, and the effects of tumour necrosis ...
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Expression of BAFF receptors in muscle tissue of myositis patients with anti Jo 1 or anti Ro52/anti Ro60 autoantibodies
... Cells positive for B cell–activating factor of the tumour necrosis factor family receptor BAFF-R A, B cell maturation antigen BCMA B or transmembrane activator and calcium modulator and [r] ...
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Inhibition of anti tuberculosis T lymphocyte function with tumour necrosis factor antagonists
... Tumour necrosis factor (TNF) antagonists such as the anti- TNF monoclonal antibodies (mAbs) infliximab (Ifx) and adali- mumab (Ada) and the soluble TNF receptor etanercept (Eta) are efficacious in ...
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Genetic polymorphisms in tumour necrosis factor receptors (TNFRSF1A/1B) illustrate differential treatment response to TNFα inhibitors in patients with Crohn’s disease
... Figure 1 Gene expression level of TNFα, TNFRSF1A and TNFRSF1B according to each allele type in selected single nucleotide polymorphisms (SNP) (A–I) among patients with Crohn’s disease (CD) (n=54) and healthy controls ...
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The effect of tumour necrosis factor-alpha and insulin on equine digital blood vessel function in vitro
... In other species, vascular and endothelial dysfunction can be caused by hyperinsulinaemia and/or insulin resistance (IR) [12] and inflammatory mediators [13]. Normally, insulin activates both the phosphatidylinositol ...
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Age-related loss of CpG methylation in the tumour necrosis factor promoter
... performed using a mixed effects model in which we included the intra-individual correlations between the methylation levels at the CpG sites. When considering the change in methylation with age, this variable was entered ...
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Tumour necrosis factor signalling in health and disease
... nuclear factor-kappa B (NF-κB) and the induction of a cell survival response, TNFR1 is also capable of inducing a cell death response depending on prevailing physiological circumstances; however, the regulation of ...
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Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal dominant Behçet's disease
... Patients 1 and 2 exhibited a very good response to glucocorticoid treatment in comparison with other cases of BD without dominantly inherited traits, although this may have been re fl ective of their poor response to col- ...
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Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis
... The two receptors appear to promote distinct TNF-α-induced cellular responses, although both are capable of inducing the nuclear factor-κB (NF-κB) and apoptotic pathways [7-10], providing some evidence of receptor ...
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Necroptosis: a new link between cell death and inflammation
... Necroptosis is a type of newly identified cell death induced by apoptotic stimuli under conditions where apoptotic execution is prevented. Studies over the past 10 years have revealed the molecular mechanism of ...
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Efficacy of ustekinumab in biologic naïve patients with psoriatic arthritis by prior treatment exposure and disease duration: data from PSUMMIT 1 and PSUMMIT 2
... Figure 1 Proportions of patients who achieved (A) ACR20/ACR50/ACR70 responses at week 24, (B) DAS28-CRP response and remission at week 24, and (C) mean changes from baseline in total PsA-modified vdH-S score at week 24 ...
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Tumour necrosis factor - alpha mediated mechanisms of cognitive dysfunction
... Mental and neurological disorders like schizophrenia and depression constitute 13% of the global disease burden, quickly surpassing the threat by cardiovascular disorders and cancer [1]. A common link between ...
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Exogenous tumour necrosis factor α induces suppression of autoimmune arthritis
... Results Arthritic LEW rats show highest levels of TNFα at the recovery phase of AA, whereas AA-resistant WKY rats exhibit an opposite profile The results of ex vivo TNFα secretion cytoki[r] ...
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