tumour progression
Cancer stem cells as key drivers of tumour progression
... the tumour progression and this process predominantly in- volves endothelial cells and pericytes ...in tumour- associated endothelial cells define the tumorigenicity of CSC in head and neck squamous ...
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An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models
... reflected tumour progression than changes in single populations (Figure ...aggressive tumour cultures (HG, ER- or HER2+) relative to non-tumour or non-aggressive tumour ...LG ...
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Cyclin G2 Inhibits the Warburg Effect and Tumour Progression by Suppressing LDHA Phosphorylation in Glioma
... a tumour suppressor in several ...a tumour suppressive role in ...a tumour suppressor in glioma by repressing glycolysis and tumour progression through its interaction with ...
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Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression
... Tumour cells adjoining stromal adipocytes have previously been shown to exert significant changes in proliferation, migration, and invasion. The ability of adi- pocytes to modify tumour progression ...
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Tumour stroma interactions: Phenotypic and genetic alterations in mammary stroma: implications for tumour progression
... of tumour progression is not sufficient in itself to provide an insight into its functional significance, in the absence of complementary data regarding alterations in stroma com- position and/or physical ...
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Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives
... cancer progression since extracellular adenosine generated after extracellular ATP hydrolysis by the ectonucleotidases CD39 and CD73 is immunosuppressive, resulting in tumour progression, metastases ...
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Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
... Thus, we show that CCT365623 is a LOX inhibitor both biochemically against the isolated enzyme and in living cells. In vitro and in vivo it recapitulates the biological effects of both BAPN and LOX depletion. The ...
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Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer
... KRAS WT/G12D , P53 WT/R172H , PDX-1CRE +/+ (KPC) trans- genic mice and control mice were maintained and geno- typed by the Animal Research Centre (Murdoch, Western Australia) according to the original protocol [12]. All ...
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Attenuation of TGFBR2 expression and tumour progression in prostate cancer involve diverse hypoxia-regulated pathways
... In an attempt to evaluate the potential of TGFBR2 as the direct target of miR-93, we firstly detected the expression pattern of miR-93 in PCa. We examined miR-93 expression levels in a panel of 45 human PCa tissues and ...
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Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.
... Thus, we show that CCT365623 is a LOX inhibitor both biochemically against the isolated enzyme and in living cells. In vitro and in vivo it recapitulates the biological effects of both BAPN and LOX depletion. The ...
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The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma
... Results: The combination of natural product Biochanin A with the BRAF inhibitor SB590885 synergistically sup- pressed proliferation, and promoted cell cycle arrest and apoptosis in vitro. Furthermore, we demonstrated ...
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Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: An analysis of 215 cases from the Malmö Diet and Cancer Study
... primary tumour was significantly associated with favourable clinicopathological parameters; ...primary tumour is an independent marker of a prolonged ...
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TP53 codon 72 polymorphism may predict early tumour progression in paediatric pilocytic astrocytoma
... IR of death or disease progression were calculated and reported with their 95% Confidence Intervals (95% CI). Survival curves were drawn to assess disease-free survival and time to the event was expressed as ...
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Overexpression of platelet derived growth factor receptor α in breast cancer is associated with tumour progression
... some tumour types, such as oesophageal squamous cell carcinoma [25], pulmonary artery intimal sarcomas (where it was demonstrated that PDGFR- α amplification is strongly associated with the development of this ...
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Kallistatin inhibits tumour progression and platinum resistance in high-grade serous ovarian cancer
... treatments for HGSOC patients [4]. Recently targeted therapy has made significant progress in ovarian can- cer, such as the vascular endothelial growth factor (VEGF) targeting drug bevacizumab and the p-oly- ADP-ribose ...
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Tissue factor, angiogenesis and tumour progression
... The direct targeting of TF with, for example, monoclonal anti- bodies or inactivating peptides has already been demon- strated efficacious in several models in vivo [69]. Moreover, inhibition of various procoagulant and ...
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Tyrosine kinase signalling in breast cancer: Tyrosine kinase mediated signal transduction in transgenic mouse models of human breast cancer
... mT-mediated tumour progression has been demon- strated by crossing the MMTV/PyV mT strains to c-src- and c-yes-deficient mice [28 •• ...mammary tumour progression, mammary epithelial expres- ...
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Stopping rules employing response rates, time to progression, and early progressive disease for phase II oncology trials
... As a model, the CSR cannot mimic disease processes with complete accuracy. The model assumes that the population undergoes tumour progression in an expo- nential distribution. It is unlikely that any one ...
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Quantitative in vivo optical tomography of cancer progression & vasculature development in adult zebrafish
... study tumour progression and vasculature development in vivo via global 3-D fluorescence imaging of live non-pigmented adult zebrafish utilising angularly multiplexed optical projection tomography with ...
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... in tumour escape and in limiting the success of cancer ...In tumour- bearing mice, another group of bone marrow derived cells may be a part of APC ...from tumour- bearing mice differentiate into ...
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