TuMV and Eukaryotic Initiation Factor Interactions
Studies of the purification of eukaryotic initiation factor 4A
... other initiation factors, eIF-4A, a 49,000 dalton protein, and eIF-4B, previously discussed, also bind free mRNA, although their function is presently ...of initiation complexes with the artificial template ...
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Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer
... Abstract Eukaryotic initiation factor 5A (eIF5A), the only known cellular protein containing the amino acid hypusine, is an essential component of translation ...
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Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... elongation factor eEF1A (previously eEF1␣), were pass eIF2B in vivo ...demonstrated factor, eEF1B, when provided on a low-copy-number recently that eIF2␣ is required to promote efficient in- ...
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Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... KARSTEN MEYER, ANKE PETERSEN, MICHAEL NIEPMANN, AND EWALD BECK* Biochemisches Institut am Klinikum der Justus-Liebig-Universita ¨t Giessen, Giessen, Germany Received 21 November 1994/Accepted 25 January 1995 We studied ...
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On the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation
... comm en t re v ie w s re ports refer e e d re sear chdeposited research interacti o ns inf o rmation eif3h, one would expect elevated polysome loading in the mutant, exactly the opposite of what was observed. The effect ...
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The Eukaryotic Translation Initiation Factor 4GI Is Cleaved by Different Retroviral Proteases
... translation initiation factor eIF4G without affecting IRES-driven translation with mRNAs having the 5⬘ leader of ...translation initiation is suppressed and IRES-mediated translation ...
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Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia
... of eukaryotic initiation fac- tor (eIF) 4E activity slows G1 progression in yeast [13] and non-transformed mammalian cells ...translation initiation and is thought to function through eIF4F, a ...
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Epstein-Barr Virus Protein EB2 Stimulates Translation Initiation of mRNAs through Direct Interactions with both Poly(A)-Binding Protein and Eukaryotic Initiation Factor 4G
... Since PABP is known to play an essential role in translation due to its association with the eIF4F cap-binding complex (CBC), the interaction of EB2 with this protein suggests that EB2 could be an active component of the ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... Thus, the eIF3 complex may act as the general scaffold- ing platform, bringing all components of the process into close proximity. Although the roles played by CB and gephyrin in this scenario have yet to be defined, our ...
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The role of eukaryotic initiation factor 2α during the metabolic depression associated with estivation
... the initiation of translation by eIF2α in estivating organisms and provides evidence for a possible mechanism by which the rate of protein synthesis is downregulated during the metabolic depression associated with ...
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Binding Specificities and Potential Roles of Isoforms of Eukaryotic Initiation Factor 4E in Leishmania
... fully replace the yeast eIF4E gene, whereas At.eIF4E-2, which encodes eIF(iso)4E, provides only partial complementation and the recovered yeast cells grow very slowly (54). The ge- nome of Drosophila melanogaster also ...
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Involvement of the eukaryotic initiation factor 6 and kermit2/gipc2 in Xenopus laevis pronephros formation
... translation initiation factor Eif6 has been implicated as a regulator of ribosome assembly, selective mRNA translation and ...growth factor (IGF) ...
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Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC
... translation initiation factors EIF4E1 and EIF4G1 effectively inhibits breast cancer stem cells (CSCs) through selectively reducing translation persistent in breast CSCs [38, ...
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Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer
... Translation initiation is the most well-studied in cancer [7]. Translation initiation is regulated by eukaryotic translation factor 4F (EIF4F) heterotrimeric complex, which is consisted of ...
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Genetic Interactions of Yeast Eukaryotic Translation Initiation Factor 5A (eIF5A) Reveal Connections to Poly(A)-Binding Protein and Protein Kinase C Signaling
... conserved eukaryotic translation initiation factor eIF5A has been proposed to have various roles in the cell, from translation to mRNA decay to nuclear protein ...
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Decreased expression of eukaryotic initiation factor 3f is an adverse prognostic factor for stage I–III gastric cancer
... The relationship between the expression level of eIF3f and prognosis The prognostic effect of eIF3f on the survival rate of GC patients was investigated by comparing the survival rate of patients with high or low levels ...
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Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention?
... from initiation to devel- opment and aggressiveness of cancer, greatly depend on the ability of translational machinery for increased syn- thesis of oncogenic ...translation initiation machinery across ...
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Emerging players in the initiation of eukaryotic DNA replication
... The initial identification of FACT and Ctf4 indicated their functions in regulating chromatin contexts, not DNA synthesis; however, recent data have clearly demon- strated the close crosstalk between DNA replication and ...
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DNA Replication-Initiation Proteins in Eukaryotic Cells
... replication factor A (RFA) binds to protect the single stranded DNA, and new DNA strands are synthesized by DNA polymerases facilitated by other replication ...replication initiation and replication fork ...
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Complex Formation between Potyvirus VPg and Translation Eukaryotic Initiation Factor 4E Correlates with Virus Infectivity
... of TuMV and eIF(iso)4E of ...various initiation factor isomers and the identification of the binding domain in a highly conserved region of the VPg are indications that the interac- tion plays an ...
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