type I IFN response
Proteolysis of MDA5 and IPS 1 is not required for inhibition of the type I IFN response by poliovirus
... the type I IFN ...in response to poly(I:C) [41]. In poliovirus-infected cells MDA-5, RIG-I and IPS-1 are all cleaved by viral and/or cellular proteases providing a potential mechanism ...
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Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response
... assessed IFN-α production in SIVagm-infected AGMs and SIVmac-infected ...peak IFN-α production. Since IFN-α responses are reflected at the molecular level by induction of ISGs, we assessed the ...
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Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons
... recombinant IFN to LACV-infected COs rescues viability ...of IFN signaling and the ISG in committed neurons correlates with in- creases cell survival during LACV infection and should be further examined as ...
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Variation in Antagonism of the Interferon Response to Rotavirus NSP1 Results in Differential Infectivity in Mouse Embryonic Fibroblasts
... in IFN-competent wild-type ...of type I IFN secretion by RRV in MEFs, RRV infection efficiently elicits type I IFN secretion by murine dendritic cells ...brisk ...
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Differential Impact of Interferon Regulatory Factor 7 in Initiation of the Type I Interferon Response in the Lymphocytic Choriomeningitis Virus-Infected Central Nervous System versus the Periphery
... regulating type I IFN genes and other genes participating in the early antiviral host ...a type I IFN response in the LCMV-infected CNS, whereas con- current elimination ...
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TRIM13 Is a Negative Regulator of MDA5-Mediated Type I Interferon Production
... gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are essential intracellular detec- tors of viral ...the type I interferon (IFN) response that is crucial for ...
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Inherited STING activating mutation underlies a familial inflammatory syndrome with lupus like manifestations
... The type I IFN response is a key component of innate immunity to viral ...enhanced type I IFN signaling as a consequence of mutations in TREX1, RNASEH2A, RNASEH2B, ...
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The Naturally Attenuated Kunjin Strain of West Nile Virus Shows Enhanced Sensitivity to the Host Type I Interferon Response
... to type I IFN were vulnerable to infection with WNV KUN and suggest that the relative lack of pathogenicity of this natural virus variant in wild-type mice or, possibly, humans can be ...
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Chronic neurodegeneration induces Type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression
... of IFN-I in different disease states (Owens et ...of IFN-I in the brain is that they are anti-inflammatory. IFN-I induce the anti-inflammatory cytokine IL-10 (Lin et ...context, ...
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Cytokine gene expression in human hepatocytes infected with dengue virus serotype 3 (strain 16562)
... the response of a hepatic cell linage, HepG2 to infection with dengue 3 virus (strain ...TGF-βIIIR), type I interferon (IFN-α and IFN-β), and pattern-recog- nition receptors (TLR3, ...
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JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN Induced Response
... detected IFN- production at 3 dpi, but no ISGs were detected at this time ...of type I IFN signaling, thus enhancing viral replication ...the IFN-mediated signaling activation blocking ...
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Immune- and miRNA-response to recombinant interferon beta-1a: a biomarker evaluation study to guide the development of novel type I interferon- based therapies
... to IFN-β in healthy humans using MRI ...phase I studies with the RIG-I ligand, the main read outs used here (ELISA and qPCR) will be validated on repeatability, precision, pre-assay effects, dilution ...
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jem_20181359.pdf
... secrete type I IFN (IFN-I) was first documented in the 1950s (Lennert and Remmele, ...these IFN-producing cells were defined and charac- terized in both humans and mice and ...
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Viral Interferon Regulatory Factors Decrease the Induction of Type I and Type II Interferon during Rhesus Macaque Rhadinovirus Infection
... (IFN) response is integral to a host’s antiviral ...(types I to III), characterized by sequence, receptor usage, and biological ac- tivity ...well-studied type I IFNs (IFN-␣ and ...
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Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction
... Type I interferon (IFN) plays a crucial role in innate immunity against viral infections [1, ...of type I IFNs is typically mediated by pattern-recognition receptors (PRRs), including ...
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Type III Interferon (IFN) Induces a Type I IFN-Like Response in a Restricted Subset of Cells through Signaling Pathways Involving both the Jak-STAT Pathway and the Mitogen-Activated Protein Kinases
... by IFN- ␣ ...the IFN- ␣ - induced genes revealed that the majority of these genes were also induced upon IFN- treatment but failed to meet the stringent statistical criteria (see the supplemental ...
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TRAM is required for TLR2 endosomal signaling to type I IFN induction
... In response to LPS, TRAM is initially mobilized to EEA1- positive early endosomes and can also be found in Rab11-positive sorting/recycling endosomes (48, ...
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Type I Interferon Signals in Macrophages and Dendritic Cells Control Dengue Virus Infection: Implications for a New Mouse Model To Test Dengue Vaccines
... both type I and type II interferon (IFN) receptors (AG129 mice) or the type I IFN receptor (IFNAR ⴚ/ⴚ mice) are susceptible to infection with mouse- adapted DENV strains ...
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Cytokine-Independent Upregulation of MDA5 in Viral Infection
... by type I IFN (7, 20), it is likely that type I IFN feedback signaling involving STAT1 is required for maximum activation of DCs through RIG-I and MDA5 ...of type ...
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β-catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-κB signaling
... (Qiagen) using the HiPerfect (Qiagen) transfection reagent. For analysis of mRNA expression, A549 cells (5 × 10 5 per 6-well dish) were transfected with X-treme Gene HP (Roche) following the manufacturer’s instructions. ...
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