Type I interferons (IFN-I)
Overview of the biology of type I interferons
... Firstly, type I interferons are widely used for the treatment of chronic viral infections, mainly by hepatitis B virus and hepatitis C virus ...that type I interferons are not ...
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Sendai Virus Infection Induces Efficient Adaptive Immunity Independently of Type I Interferons
... responses. Type I interferons (IFNs), including IFN- ␣ and -  , are produced by most cells upon virus infection and constitute the main innate antiviral ...response. Type I ...
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Species independent bioassay for sensitive quantification of antiviral type I interferons
... Type-I interferons (IFN-a/b) are potent cytokines that can be released from virtually all vertebrate cells follow- ing viral ...of IFN- a subspecies and a single IFN- b , and ...
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Effects of Type I Interferons on Friend Retrovirus Infection
... example, IFN induces the maturation of dendritic cells (19), which is important for the stimulation of T ...that IFN-  ⫺/⫺ and IFNAR ⫺/⫺ mice have fewer T cells during retroviral infection than ...
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Evidence for a Different Susceptibility of Primate Lentiviruses to Type I Interferons
... Type I interferons induce a complex transcriptional program that leads to a generalized antiviral response against a large panel of viruses, including human immunodeficiency virus type 1 ...
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Type I Interferons and NK Cells Restrict Gammaherpesvirus Lymph Node Infection
... whether IFN-I restricts MHV-RG prop- agation in SSM, we gave IFNAR-blocking antibody or not and then ...5). IFN-I blockade in- creased day 6 virus titers, most noticeably in spleens ...
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Identification and Characterization of Novel Type I Interferons in Pteropus vampyrus Bats.
... human STAT2 to efficiently suppress IFN signaling [225]. Similarly, the interferon antagonistic ability of EBOV VP24 has been suggested to be a major determinant in resistance of mice to the Zaire ebolavirus ...
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Type I interferons regulate susceptibility to inflammation-induced preterm birth
... tial type I IFN sensitization is required for dysregulated proinflammatory cytokine ...robust type I IFNs will similarly play a critical role in controlling susceptibility to secondary ...
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Vaccinia Virus K1L and C7L Inhibit Antiviral Activities Induced by Type I Interferons
... that IFN-  inhibited only the translation of intermediate mRNAs and did not affect the level of inter- mediate gene transcripts, so it is unlikely that the 2 ⬘ -5 ⬘ oligo- adenylate synthetase (OAS)/RNase L ...
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Alphavirus evasion of type I interferons
... wild type virus but are unable undergo multiple rounds of replication ...that IFN-αβ differences between mam- and mos-VRP infected cultures or animals would show more dramatic differences between the two ...
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Chronic neurodegeneration induces Type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression
... of IFN-I on the long-term outcome of ME7 prion disease, survival of ME7-inoculated IFNAR1 −/− mice was analyzed and FIGURE 6 Type I interferons (IFN-I), neuroinflammatory, ...
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Double-Stranded RNA Induces Biphasic STAT1 Phosphorylation by both Type I Interferon (IFN)-Dependent and Type I IFN-Independent Pathways
... of type I interferons (IFNs), which initiate antiviral ...activities. Type I IFNs bind to their cognate receptor, IFNAR, resulting in the activation of signal- transducing activators of ...
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Malaria parasite DNA harbouring vesicles activate cytosolic immune sensors
... P athogens are sensed by pattern recognition receptors (PRR) of the mammalian innate immune system, which directly recognize pathogen-associated molecular patterns (PAMP), and also host-derived damage-associated ...
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Impact of genotype 1 and 2 of porcine reproductive and respiratory syndrome viruses on interferon-α responses by plasmacytoid dendritic cells
... immunity. Type I interferons (IFN) are essential for mounting efficient antiviral innate and adaptive immune responses, but in a recent study, North American PRRSV genotype 2 isolates did not ...
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HIV Blocks Interferon Induction in Human Dendritic Cells and Macrophages by Dysregulation of TBK1
... produce type I interferons (IFNs) in response to HIV-1 but that, unlike T cells, the virus does not block IFN induction by targeting IFN regulatory factor 3 (IRF3) for cellular ...
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Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1
... Our study demonstrates that influenza virus induces degradation of the cellular receptor of type I IFNs, the potent antiviral mole- cules. Importantly, viral HA protein was shown to cause IFNAR1 FIG 5 ...
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Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction
... cell type- and stimulus-specific (Table ...for type I IFN induction by both TLR ligands and viruses in ...virus-induced type I IFN induction, although it inhibited ...
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Cytokine-Independent Upregulation of MDA5 in Viral Infection
... binding sites in the murine IP10 and IFN- ␣ 4 promoters were com- pared with putative IRF3 binding sites in the murine and human MDA5 promoter regions. Boxes highlight GAAA motifs required for IRF3 binding. (b) ...
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Type I Interferon Signals in Macrophages and Dendritic Cells Control Dengue Virus Infection: Implications for a New Mouse Model To Test Dengue Vaccines
... both type I and type II interferon (IFN) receptors (AG129 mice) or the type I IFN receptor (IFNAR ⴚ/ⴚ mice) are susceptible to infection with mouse- adapted DENV strains ...
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β-catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-κB signaling
... of IFN-β expression upon IAV ...CBP/p300, IFN-β transcription ...the IFN-β activation pathway provoked by viral RNA, this was fur- ther affirmed via comparison of the dimerization cap- acity of IRF3 ...
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