type VI secretion system
The Tip of the VgrG Spike Is Essential to Functional Type VI Secretion System Assembly in Acinetobacter baumannii
... ABSTRACT The type VI secretion system (T6SS) is a critical weapon in bacterial war- fare between Gram-negative bacteria. Although invaluable for niche establishment, this machine represents an ...
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Physiological Heterogeneity Triggers Sibling Conflict Mediated by the Type VI Secretion System in an Aggregative Multicellular Bacterium
... the type VI secretion system (T6SS) as well as gliding motility; in particular, we identified the effector-immunity pair (TsxEI) as the mediator of this ...
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Double Tubular Contractile Structure of the Type VI Secretion System Displays Striking Flexibility and Elasticity
... The type VI secretion system (T6SS) is one such lethal weapon used by many Gram-negative bacteria to deliver toxic effectors into neighboring bacterial and eukaryotic cells ...
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Critical role of a sheath phosphorylation site on the assembly and function of an atypical type VI secretion system
... non-canonical type VI secretion system (T6SS) that is required for phagosomal escape in infected ...and secretion of the T6SS in ...
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Clinical impact of the type VI secretion system on virulence of Campylobacter species during infection
... the Type VI Secretion System (T6SS) [8], one of several bacterial systems for protein secretion ...contact-dependent secretion of effectors into other bacterial or host cells ...
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Structural insights into the function of type VI secretion system TssA subunits.
... The type VI secretion system (T6SS) is a multi-protein complex that injects bacterial effector proteins into target cells. It is composed of a cell membrane complex anchored to a con- tractile ...
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The CpxR regulates type VI secretion system 2 expression and facilitates the interbacterial competition activity and virulence of avian pathogenic Escherichia coli
... tion system (TCS) regulates surface structure assembly and virulence factors implicated in Gram-negative bacterial ...APEC type VI secretion system 2 ...
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Secretome Analysis of Vibrio cholerae Type VI Secretion System Reveals a New Effector Immunity Pair
... The type VI secretion system (T6SS) is a dynamic macromolecular organelle that many Gram-negative bacteria use to inhibit or kill other prokaryotic or eukaryotic ...
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Polar localization of the ATPase ClpV 5 occurs independent of type VI secretion system apparatus proteins in Burkholderia thailandensis
... The type VI secretion system (T6SS) is a widespread nanomachine bearing considerable structural and mecha- nistic similarity to contractile phage tails ...
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Diversification of Type VI Secretion System Toxins Reveals Ancient Antagonism among Bee Gut Microbes
... However, we also found that T6SS presence and toxin abundance vary among strains. The loss of T6SSs in some lineages indicates that participation in this mode of competition may not always be beneficial. Human gut ...
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Analysis of Vibrio cholerae genomes identifies new type VI secretion system gene clusters
... Results: We sequence two dozen V. cholerae strain genomes from diverse sources and develop a novel and adaptable bioinformatics tool based on hidden Markov models. We identify two new T6SS auxiliary gene clusters and ...
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A Transcriptional Regulatory Mechanism Finely Tunes the Firing of Type VI Secretion System in Response to Bacterial Enemies
... Which signals are able to induce Serratia T6SS expression? The components of A. baumannii’s T6SS have been comprehensively analyzed in a previous work by Weber et al. (13), showing that the T6SS gene cluster encodes four ...
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Genetic Dissection of the Type VI Secretion System in Acinetobacter and Identification of a Novel Peptidoglycan Hydrolase, TagX, Required for Its Biogenesis
... to secretion of effector proteins, contraction of the T6SS also leads to the export of two hallmark proteins, Hcp and ...for secretion and required for T6SS activity, multiple similar VgrG proteins are ...
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Understanding the sequential activation of Type III and Type VI Secretion Systems in Salmonella typhimurium using Boolean modeling
... the Type VI Secretion System (T6SS) has also been reported to be functionally active in ...these secretion systems of the pathogen is depicted in Figure ...
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Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor
... a type VI secretion system locus, is expressed in vivo, is involved in controlling bacterial mem- brane lipid composition, and is a new virulence ...
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The pseudomonas aeruginosa Type VI secretion PGAP1 like effector induces host autophagy by activating endoplasmic reticulum stress
... The type VI secretion system (T6SS) is responsible for the secretion of numerous virulence effector proteins that can both interfere with competing microbes and manipulate host ...
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Engineering the flagellar type III secretion system: improving capacity for secretion of recombinant protein.
... improved secretion in the absence of the 3 ′ UTR, as FlgM might be more readily secreted from the FT3SS—how- ever at this time we have no evidence to support this the- ...direct secretion and ensure ...
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EspZ of Enteropathogenic and Enterohemorrhagic Escherichia coli Regulates Type III Secretion System Protein Translocation
... ABSTRACT Translocation of effector proteins via a type III secretion system (T3SS) is a widespread infection strategy among Gram-negative bacterial pathogens. Each pathogen translocates a particular ...
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Migration of Type III Secretion System Transcriptional Regulators Links Gene Expression to Secretion
... unaltered secretion profile of HrpA2, HrpZ1 showed dramatic differences in its extracellular and intracellular detection for wild-type ...a secretion- incompetent mutant. The absence of HrpZ1 ...
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Engineering the flagellar type III secretion system: improving capacity for secretion of recombinant protein
... the secretion signal employed in the plasmid- based modular secretion ...All secretion construct (denoted SC) variants were inserted in frame with the cutinase gene, with the predicted size in kDa ...
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