type VI secretion system (T6SS)
Clinical impact of the type VI secretion system on virulence of Campylobacter species during infection
... the Type VI Secretion System (T6SS) [8], one of several bacterial systems for protein secretion ...the T6SS allows the contact-dependent secretion of effectors into ...
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Structural insights into the function of type VI secretion system TssA subunits.
... The type VI secretion system (T6SS) is a multi-protein complex that injects bacterial effector proteins into target cells. It is composed of a cell membrane complex anchored to a con- ...
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Secretome Analysis of Vibrio cholerae Type VI Secretion System Reveals a New Effector Immunity Pair
... The type VI secretion system (T6SS) is a dynamic macromolecular organelle that many Gram-negative bacteria use to inhibit or kill other prokaryotic or eukaryotic ...of T6SS are ...
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Critical role of a sheath phosphorylation site on the assembly and function of an atypical type VI secretion system
... non-canonical type VI secretion system (T6SS) that is required for phagosomal escape in infected ...and secretion of the T6SS in ...the T6SS proteins remained ...
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Physiological Heterogeneity Triggers Sibling Conflict Mediated by the Type VI Secretion System in an Aggregative Multicellular Bacterium
... the type VI secretion system (T6SS) as well as gliding motility; in particular, we identified the effector-immunity pair (TsxEI) as the mediator of this ...the T6SS from the ...
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Double Tubular Contractile Structure of the Type VI Secretion System Displays Striking Flexibility and Elasticity
... The type VI secretion system (T6SS) is a widespread molecular weapon for interspecies interactions and virulence, comprising a long double tubular struc- ture and a ...
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Polar localization of the ATPase ClpV 5 occurs independent of type VI secretion system apparatus proteins in Burkholderia thailandensis
... the type VI secretion system (T6SS) recycles cytoplasmic T6SS proteins following effector ...targeting T6SS‑1 of Burkholderia thailandensis exhibits a virtually random ...
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The Tip of the VgrG Spike Is Essential to Functional Type VI Secretion System Assembly in Acinetobacter baumannii
... The type VI secretion system (T6SS) is a critical weapon in bacterial war- fare between Gram-negative ...the T6SS is transcriptionally downregulated by large multidrug resistance ...
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The CpxR regulates type VI secretion system 2 expression and facilitates the interbacterial competition activity and virulence of avian pathogenic Escherichia coli
... tion system (TCS) regulates surface structure assembly and virulence factors implicated in Gram-negative bacterial ...APEC type VI secretion system 2 ...
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Analysis of Vibrio cholerae genomes identifies new type VI secretion system gene clusters
... Prior studies noted the difficulty involved with accurate identification and classification of diverse T6SS proteins. Unterweger et al. used a common approach, “uclust-then- BLAST,” in which predicted proteins are ...
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Diversification of Type VI Secretion System Toxins Reveals Ancient Antagonism among Bee Gut Microbes
... The accumulation of numerous, potentially functional Rhs genes in S. alvi stands in contrast to what is found in many previously characterized bacteria: Serratia marcescens has two Rhs toxins (27), Dickeya dadantii 3937 ...
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Genetic Dissection of the Type VI Secretion System in Acinetobacter and Identification of a Novel Peptidoglycan Hydrolase, TagX, Required for Its Biogenesis
... of T6SS-containing organisms, and delivery depends on the assem- bly of a core set of 13 conserved T6SS genes (9), called tss genes, as well as a variable number of T6SS-associated genes (tag genes), ...
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A Transcriptional Regulatory Mechanism Finely Tunes the Firing of Type VI Secretion System in Response to Bacterial Enemies
... chances. Type VI secretion systems (T6SSs) are complex bacterial contractile nanomachines able to target toxic effectors into neighboring bacteria competing for the same colonization ...its ...
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Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts
... The type VI secretion system (T6SS) represents a new paradigm of protein secretion and is a key virulence factor for many important pathogenic bacteria contributing to dif- ...
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Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor
... alveolar type II cells ...characterized. Type VI secretion system (T6SS) putative genes were lo- cated in at least three different loci of the ...[38]. T6SS clusters are ...
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Understanding the sequential activation of Type III and Type VI Secretion Systems in Salmonella typhimurium using Boolean modeling
... The presence of several binding sites of YfhA (and its homolog FlrC) in the upstream regions and ORFs of rcsB and sciS, coupled to the fact that YfhA is also a non- cognate response regulator of EnvZ, strongly indicates ...
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An Investigation of the Molecular Mechanism of Identity Communication in the Social Bacterium Proteus Mirabilis
... a type VI secretion (T6S) system and putative cytotoxic elements, respectively, are needed for compe- tition with other ...T6S system has been shown to translocate ...
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Self Labeling Enzyme Tags for Analyses of Translocation of Type III Secretion System Effector Proteins
... SRM has been recently applied to the study of the T3SS translocon assembly during infection by Y. enterocolitica (17) and to analysis of the distribution of SPI2-T3SS effector protein SseJ in STM-infected cells (18). Due ...
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Control of Type III Secretion System Effector/Chaperone Ratio Fosters Pathogen Adaptation to Host Adherent Lifestyle
... ABSTRACT The transition from a planktonic lifestyle to a host-attached state is of- ten critical for bacterial virulence. Upon attachment to host cells, enteropathogenic Escherichia coli (EPEC) employs a type III ...
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Extracytoplasmic stress responses induced by a model secretin : a dissertation presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Manawatū, New Zealand
... and type 4 capsule polysaccharide export operons, wza-wzb-wzc-wcaAB and yjbEFGH, respectively, and inhibit expression of motility regulator, flhDC, and the curli pilin assembly operon, csgDEFG (Wehland & ...
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