Ubiquitin-conjugating enzyme
The Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Requires the Ubiquitin-Conjugating Enzyme Ubc13 for NF-κB Activation
... Ubiquitination of the human T-cell leukemia virus 1 Tax oncoprotein provides an important regulatory mechanism that promotes the Tax-mediated activation of NF- B. However, the type of polyubiquitin chain linkages and ...
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Effect of prolonged intravenous glucose and essential amino acid infusion on nitrogen balance, muscle protein degradation and ubiquitin-conjugating enzyme gene expression in calves
... the ubiquitin proteasome ...in ubiquitin-conjugating enzyme 14-kDa E2 mRNA and C2 proteasome sub unit, and a small trend for a decrease in Ubiquitin and the C8 proteasome sub ...the ...
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Functional Interaction between Human Herpesvirus 6 Immediate-Early 2 Protein and Ubiquitin-Conjugating Enzyme 9 in the Absence of Sumoylation
... The immediate-early 2 (IE2) protein of human herpesvirus 6 is a potent transactivator of cellular and viral promoters. To better understand the biology of IE2, we generated a LexA-IE2 fusion protein and screened, using ...
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Cdc34p Ubiquitin-Conjugating Enzyme Is a Component of the Tombusvirus Replicase Complex and Ubiquitinates p33 Replication Protein
... chaperones, ubiquitin-associated proteins, translation factors, RNA-modifying enzymes, and other proteins with yet-unknown ...E2 ubiquitin-conjugating enzyme, which is one of the host proteins ...
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lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2
... minimal ubiquitin ligase activity of the APC/C, depend- ing on the type of ubiquitin conjugating enzyme (E2) used in these reactions ...E2 enzyme Ubc4 and therefore inhibits the ...
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Ubiquitin conjugating enzyme involved in the immune response caused by pathogens invasion
... [1], ubiquitin-proteasome pathway (UPP) is responsible for the degradation of 80% - 90% bulk protein in eukaryotic cell ...of ubiquitin-activating en- zyme (E1), ubiquitin-conjugating ...
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The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis
... the ubiquitin-proteasome pathway under the direction of ubiquitin ligase HERC4 ...its ubiquitin- conjugating enzyme is yet to ...
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Structure-Function Analysis of Yeast mRNA Cap Methyltransferase and High-Copy Suppression of Conditional Mutants by AdoMet Synthase and the Ubiquitin Conjugating Enzyme Cdc34p
... the ubiquitin conjugating enzyme Cdc34p as a high-copy abd1 ...its ubiquitin conjugation activity or its capacity to interact with the E3-SCF complex abrogate its abd1 suppressor ...
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RING-H2 Protein WSSV249 from White Spot Syndrome Virus Sequesters a Shrimp Ubiquitin-Conjugating Enzyme, PvUbc, for Viral Pathogenesis
... by ubiquitin is essential for numerous cellular ...in ubiquitin-conjugating enzyme (E2)-dependent ...shrimp ubiquitin-conjugating enzyme, PvUbc, and mediates ...
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Functional Characterization of Residues Required for the Herpes Simplex Virus 1 E3 Ubiquitin Ligase ICP0 To Interact with the Cellular E2 Ubiquitin-Conjugating Enzyme UBE2D1 (UbcH5a)
... E3 ubiquitin ligases counteract multiple aspects of antiviral immunity using a variety of ...E2 ubiquitin-conjugating enzymes to induce both monoubiquitination and K63-linked polyubiquitination of ...
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Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage
... both ubiquitin-dependent and ubiquitin-independent pro- teasome pathways ...The ubiquitin-proteasome system (UPS) regulates cellular protein homeostasis by removing abnormal proteins in response to a ...
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Ubiquitin conjugating enzyme complex Uev1A Ubc13 promotes breast cancer metastasis through nuclear factor кB mediated matrix metalloproteinase 1 gene regulation
... Figure 3 Depletion of ubiquitin conjugating enzyme variant (Uev)1 reduces cell invasion in vitro and metastasis in a xenograft mouse model. (A) MDA-MB-231 cells were transfected with shRNA lentiviral ...
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Effete, a Drosophila Chromatin-Associated Ubiquitin-Conjugating Enzyme That Affects Telomeric and Heterochromatic Position Effect Variegation
... E2 ubiquitin-conjugating enzyme encoded by the eff ...in ubiquitin-mediated degradation of several Drosophila proteins, including the Drosophila Inhibitor of Apotosis Protein 1 (DIAP1) (Ryoo ...
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Microarray-based analysis and clinical validation identify ubiquitin-conjugating enzyme E2E1 (UBE2E1) as a prognostic factor in acute myeloid leukemia
... Results: Microarray-based analysis suggested that expression of eight genes was each associated with 1-year and 3-year AML OS in both GSE12417 and GSE8970 datasets ( p < 0.05). Next, we validated our findings in an ...
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Ubiquitin conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection
... years, ubiquitin modifications have been re- ported as important regulators of antiviral innate re- sponses including the interferon signaling ...of ubiquitin is conjugated to the α -amino group of ...
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Gene expression in HCV-associated HCC-identification of an up-regulated gene encoding a protein related to ubiquitin conjugating enzyme
... of ubiquitin conjugated proteins was higher in B-CLL compared with normal human lymphocytes and that alteration in the ubiquitin- proteasome system in B-CLL was associated with modification of the ...
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Molecular cloning and characterization of pigeon (Columba liva) ubiquitin and ubiquitin-conjugating enzyme genes from pituitary gland library
... is ubiquitin, a highly conserved protein that appears to play a role in the chromatin structure and in an ATP-dependent proteolytic degradation of unstable cellular proteins ...uitin-conjugating ...
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Ubiquitin control of S phase: a new role for the ubiquitin conjugating enzyme, UbcH7
... the ubiquitin proteasome proteolytic ...of ubiquitin conjugating enzymes, or E2s, functions in control of the cell cycle have been defined for only UbcH10 and ...one ubiquitin ligase or ...
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A ubiquitin-conjugating enzyme, RAD6, affects the distribution of Ty1 retrotransposon integration positions.
... T h e sizes of the altered EcoRI bands defined the orientation of the Tyl ele- ments and indicated that four area IV insertions were probably Ty2 elements since they di[r] ...
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Original Article Bioinformatics analysis of gene expression profiles in chronic lymphocytic leukemia
... (Ubiquitin-Conjugating Enzyme E2I), CBLB (Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase) and SIRT1 (Sirtuin 1) with higher degrees in PPI network for down-regulated genes were important ...
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