Ubiquitin Specific Peptidase
Ubiquitin specific peptidase 5 regulates colorectal cancer cell growth by stabilizing Tu translation elongation factor
... subfamilies: ubiquitin-specific proteases, ubiquitin C-terminal hydrolases, ovarian tumor proteases, Josephins, JAMMs, and MINDYs ...[7]. Ubiquitin specific peptidase 5 (USP5) ...
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Original Article Gain of microRNA-103 triggers metastatic behavior by targeting ubiquitin specific peptidase 10 in pancreatic cancer
... Abstract: Emerging studies have shown that microRNAs (miRNAs) play key roles in regulating progression of pancre- atic cancer (PaCa). miR-103 has been reported to serve as an oncomiR in hepatocellular carcinoma and ...
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miR-34b inhibits nasopharyngeal carcinoma cell proliferation by targeting ubiquitin-specific peptidase 22
... USP22, ubiquitin-specific peptidase 22; RT-PCR, reverse transcription-polymerase chain reaction; NPC, nasopharyngeal carcinoma; MTT, 3-(4,5-dimethyl- 2-thiazolyl)-2,5-diphenyl-2h-tetrazolium bromide; ...
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Expression of ubiquitin specific peptidase and ATG7 genes in U87 glioma cells upon glutamine deprivation
... Ubiquitin specific peptidase 4 function is im- portant during tumorigenesis because this deubiqui- tinating enzyme has a key role in the regulation of TP53 and TGFβ signaling and is also a positive ...
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Lentivirus mediated silencing of Ubiquitin Specific Peptidase 39 inhibits cell proliferation of human hepatocellular carcinoma cells in vitro
... [11,12]. Ubiquitin Specific Peptidase 39 (USP39) is a 65 kDa SR-related protein in human cells involved in as- sembly of spliceosome, as well as a deubiquitinating en- zyme without protease activity ...
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Ubiquitin-Specific Peptidase 20 Targets TRAF6 and Human T Cell Leukemia Virus Type 1 Tax To Negatively Regulate NF-κB Signaling
... Tax- and IL-1  -induced NF- B activation. (A) Sequence-specific siRNA was used to knock down USP20. The knockdown of cell- endogenous USP20 by siRNA was confirmed with real-time RT-PCR. USP20-specific ...
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Ubiquitin specific peptidase 21 regulates interleukin-8 expression, stem-cell like property of human renal cell carcinoma
... underlying DNA sequence [7–11]. USP21, which can epigenetically activate transcriptional activity of target genes, is a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes ...
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Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro
... tin peptidase also affected p21 expression in breast can- cer cell which inhibited the activity of cyclin-dependent kinase 1 (CDK1) [27], an essential regulator of mitosis as it controls the centrosome cycle as ...
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The Ubiquitin-Specific Peptidase USP15 Regulates Human Papillomavirus Type 16 E6 Protein Stability
... proteins are also targeted for degradation in an E6AP-depen- dent manner (22, 29). While the major mechanism of onco- genesis revolves around E6’s ability to inhibit the proapoptotic effects of p53, recent work involving ...
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<p>Ubiquitin-specific peptidase 28 enhances STAT3 signaling and promotes cell growth in non-small-cell lung cancer</p>
... Notes: (A, B) Myc-USP28 or Flag-STAT3 plasmids were transfected into HEK293T for 36 hours, and then whole cell lysates were prepared for reciprocal Co-IP and immunoblotting against specific antibodies as ...
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Young scientists conference “Modern aspects of Biochemistry and Biotechnology – 2018”
... of ubiquitin specific peptidase (USP) and cathepsin (CTS) genes, during glutamine depri- vation in wild type U87 glioma cells (control cells) and cells with inhibited ...
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SUMO specific proteases/isopeptidases: SENPs and beyond
... Regulated deconjugation of SUMO from its substrates is a central element of the SUMO system as it assures the plasticity of protein interaction networks. The deconjuga- tion process is catalyzed by a family of cysteine ...
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Prevalence of Plasmodium falciparum delayed clearance associated polymorphisms in adaptor protein complex 2 mu subunit (pfap2mu) and ubiquitin specific protease 1 (pfubp1) genes in Ghanaian isolates
... Malaria is still a debilitating disease, especially in sub- Saharan Africa (sSA) where there were 212 million cases and 429,000 malaria-related deaths in 2015 [1]. There has been a 21 and 29% reduction in morbidity and ...
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Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle
... Serum/plasma cellular proteins represent complex bio- logical systems, and it has to be considered that NPs can form Bio/Nano complexes when exposed to several, very different systems in vivo. An inhaled NP may pass ...
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Reciprocal Activities between Herpes Simplex Virus Type 1 Regulatory Protein ICP0, a Ubiquitin E3 Ligase, and Ubiquitin-Specific Protease USP7
... cellular ubiquitin-spe- cific protease enzyme USP7 (HAUSP) (17), and we have shown that this interaction protects ICP0 from auto-ubiquiti- nation in vitro and RING finger- and proteasome-dependent degradation ...
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Mutagenesis of the Active-Site Cysteine in the Ubiquitin-Specific Protease Contained in Large Tegument Protein pUL36 of Pseudorabies Virus Impairs Viral Replication In Vitro and Neuroinvasion In Vivo
... Herpesviruses specify a ubiquitin-specific protease activity located within their largest tegument protein. Although its biological role is still largely unclear, mutation within the active site abolished ...
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Core Protein of Pestiviruses Is Processed at the C Terminus by Signal Peptide Peptidase
... Two different mechanisms of release of core protein from the polyprotein have been described for members of the Fla- viviridae. Members of the genus Flavivirus (e.g., yellow fever virus [YFV]) employ the virally encoded ...
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Epstein-Barr Virus Encodes Three Bona Fide Ubiquitin-Specific Proteases
... with specific DUB subfamilies, BGLF4 and BBLF4 clus- tered with the OTU subfamily and BcLF1 ORF aligned with JAMMs (not shown), but the homologous regions did not contain Cys or His residues, and these viral ORFs ...
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A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase
... A conditional SpsB-deficient strain was generated by inserting a Tar- geTron (Tgn; a Lactococcus lactis LI.LtrB group II intron) into the spsB gene and coexpressing a temperature-sensitive plasmid, pNL9164-ltrA, that ...
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Transcriptome analysis of peripheral blood mononuclear cells in human subjects following a 36 h fast provides evidence of effects on genes regulating inflammation, apoptosis and energy metabolism
... The expression profiles of a number of genes, selected on the basis of array data analysis, were checked by real-time RT- qPCR. The RT-qPCR was performed using an ABI Prism 7300 (Applied Biosystems) for each of four test ...
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