UC-MSCs
Concise Review on Clinical Applications of Conditioned Medium Derived from Human Umbilical Cord-Mesenchymal Stem Cells (UC-MSCs)
... MSCs are population of stem cells with greater self-renewal and ...multipotentiality. MSCs are potential seed cells in regenerative medicine and have been used for the treatment of various ...especially ...
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Multiple injections of human umbilical cord derived mesenchymal stromal cells through the tail vein improve microcirculation and the microenvironment in a rat model of radiation myelopathy
... of UC-MSCs still survived in the radiation-injured spinal cord due to some limitations of immunohistochemical ...injected MSCs may survive, engraft, differenti- ate into specific cell types, and ...
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The Potential of Basal Medium Astemporary Prolong Culture of Umbilical Cord Derived Mesenchymalstem Cells
... Keeping harvested cell suspension in storage solution is often needed due to incompatible harvesting time and stem cell application schedule, either in clinical or preclinical setting, such as in organoid culture, where ...
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Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis
... performed UC-MSC treatment to explore the efficacy and the underlying mechanisms of UC-MSCs in the treatment of ...that UC-MSCs could migrate to the kidneys and effectively repair renal ...
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Original Article Human umbilical cord mesenchymal stem cells restore imatinib and doxorubicin sensitivity in drug-resistant chronic myeloid leukemia cells
... in UC-MSC-mediated chemosensitivity, we ana- lyzed expression in imatinib-sensitive and-res- istant cell lines following co-culture with UC- ...with UC-MSCs (Figure ...to UC-MSC ...
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Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis
... of UC-MSCs on T cells and FLSs in human RA promoted us to investigate the potential therapeutic effects of UC-MSCs in CIA, which is an arthritis model that shares a number of clinical, ...
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Comparison of osteogenic differentiation capacity in mesenchymal stem cells derived from human amniotic membrane (AM), umbilical cord (UC), chorionic membrane (CM), and decidua (DC)
... identified MSCs from placental tissues, including the amniotic membrane (AM) [13], the umbilical cord (UC) [14], the chorionic membrane (CM) [15], and the decidua (DC) ...
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Analysis of Treatment of 3 Patients with Acute-on-Chronic Liver Failure
... Male, 48 years old, with a history of chronic hepatitis B, had been treated with entecavir for antiviral therapy for two years, which has been stopped without doctors’ guidance for five months till now. Two weeks ago, the ...
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Clinical evaluation of haploidentical hematopoietic combined with human umbilical cord-derived mesenchymal stem cells in severe aplastic anemia
... UC-MSCs: umbilical cord mesenchymal stem cells; SAA: severe aplastic anemia; GVHD: graft versus host disease; HSCT: hematopoietic stem cell transplantation; HLA: the human leukocyte antigen; aGVHD: acute ...
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Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial
... Background: Intrauterine adhesions (IUA) are the most common cause of uterine infertility and are caused by endometrium fibrotic regeneration following severe damage to the endometrium. Although current stem cell ...
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Transplantation of umbilical cord-derived mesenchymal stem cells into the striata of R6/2 mice: behavioral and neuropathological analysis
... high-passage UC MSCs showed positive expression of SCA1, a marker of mouse MSCs (Figure ...low-passage UC MSCs displayed ...high-passage UC MSCs displayed ...low-passaged ...
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Polycaprolactone nanofiber scaffold enhances the osteogenic differentiation potency of various human tissue-derived mesenchymal stem cells
... endowed MSC-based therapy with a great potential therapeutic strategy for wound healing and tissue regen- eration, which is also thanks to few ethical issues and low risk of tumorigenesis in contrast to embryonic stem ...
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Intravenous injection of allogeneic umbilical cord-derived multipotent mesenchymal stromal cells reduces the infarct area and ameliorates cardiac function in a porcine model of acute myocardial infarction
... progenitor cells [6, 27]. In our study, we demonstrated that UC-MSCs attenuated inflammation and increased angiogenesis in the infarct and peri-infarct area of the in- farcted heart. Moreover, we also ...
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Mechanical fibrinogen depletion supports heparin free mesenchymal stem cell propagation in human platelet lysate
... of UC-MSCs, fibrinogen and hep- arin do critically influence at least proliferative capac- ...ity. UC-MSCs of the same donor primarily isolated and maintained in the absence of fibrinogen, but ...
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Allogeneic mesenchymal stem cells as induction therapy are safe and feasible in renal allografts: pilot results of a multicenter randomized controlled trial
... by MSCs in deceased donor renal transplantation ...autologous MSCs, which possess several key disadvantages due to lack of donor selection and availability “off-the-shelf” for clinical use without the delay ...
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Umbilical cord-derived mesenchymal stem cells on scaffolds facilitate collagen degradation via upregulation of MMP-9 in rat uterine scars
... human UC-MSCs was checked by adipogenic, osteogenic and neural-like differentiation assays at the fourth ...differentiation, UC-MSCs seeded on poly-L-lysine-coated coverslips in a 24-well ...
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Simple production method of umbilical cord derived mesenchymal stem cell using xeno free materials for translational research
... get UC-MSCs using xeno-free material to provide safe MSCs for translational research in regenerative ...conclusion, UC-MSCs can be isolated and expanded easily in 10% PC containing ...
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Regeneration of a full-thickness defect of rotator cuff tendon with freshly thawed umbilical cord-derived mesenchymal stem cells in a rat model
... manipulate UC MSCs, no difference was found in CPDL, proliferation, pluripotent stem cell markers, or differenti- ation among UCMSCs with passages 2, 3, 7, and 9, and the stemness persisted even with ...
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Proteomic analysis of porcine mesenchymal stem cells derived from bone marrow and umbilical cord: implication of the proteins involved in the higher migration capability of bone marrow mesenchymal stem cells
... differential protein levels between the technical repli- cates was assessed by using a scatter plot (Figure 3B). Briefly, the x-axis represents the log value of the iTRAQ ratios of the UC-MSCs to ...
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Over expression of Nrf2 in Umbilical Cord-derived Mesenchymal Stem Cells Up regulates Cytoprotective Genes, TXNRD1 and GCLC
... Methods: 3-5 passages of UC-MSCs were cultured. Recombinant vector containing Nrf2 (pcDNA3.1-Nrf2) and empty vector were transfected into MSCs using FuGENE HD. After exposing the cells to UV light ...
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