UCP2, UCP3
UCP2 and UCP3 in muscle controlling body metabolism
... homologues UCP2 and UCP3, it has become evident that these novel uncoupling proteins are unlikely to play an important role in the regulation of adaptive ...However, UCP2 and UCP3 are able to ...
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Uncoupling protein 2 polymorphisms as risk factors for NTDs
... Uncoupling proteins are mitochondrial membrane transporters that disrupt the coupling between the mitochondrial proton gradient and ATP synthesis. UCP1, found in the inner mitochondrial membrane of brown adipose tissue, ...
10
Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo
... of UCP2 and UCP3; thus, untreat- ed cells failed to show any detectable ...human UCP3 (hUCP3), a punc- tate mitochondrial staining appeared, which was completely abolished after preincubation of the ...
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Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
... both UCP3 polymorphisms arose on the African continent and genotype frequencies have remained undisturbed in the two related ...both UCP2 and UCP3 in obese and lean individuals increase ...alter ...
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Superoxide mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction
... how UCP2 activ- ity is acutely regulated inside ...vated UCP2 and its homologs UCP1 and UCP3 ...increase UCP2 protein in islets (10, 11), it is possible that, under hyperglycemic conditions ...
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Increased uncoupling protein 2 and 3 mRNA expression during fasting in obese and lean humans
... human UCP2 and -3 mRNA levels by RT–competitive PCR. Top, Determination of UCP2 mRNA level in adipose tissue of an obese subject before ...of UCP3 mRNA level in skeletal muscle of the same obese ...
7
The ACE I/D gene variant predicts ACE enzyme content in blood but not the ACE,
... skeletal muscle ACE, UCP2 or UCP3 protein content at baseline or post HIIE. These results, 413[r] ...
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Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice
... (B) UCP2 in the spleen of one-month-old female and male mice; (C) UCP3 in SkM of one-month-old female and male mice; and (D) UCP4 in the brain of five-month-old female and male mice compared to a tissue ...
10
Effect of conjugated linoleic acid on inhibition of prolyl hydroxylase 1 in hearts of mice
... for UCP2 and UCP3, there is a consensus that the primary function of UCP2 and UCP3 is to attenuate mitochondrial production of free radical to protect against oxidative damage, degenerative ...
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The Role of Mitochondrial Uncoupling Protein 3 in T Cell Function
... Nancy-520 was warmed to RT. For genotyping experiments and reverse transcription (RT)-PCR experiments, 1.5 or 2.5 % (w/v) agarose gels were prepared by boiling 1.5 or 2.5 grams (g), respectively, of agarose in 100 mL of ...
379
The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction
... the UCP2-866AA genotype and CHD have been shown to have lower total antioxidant status and higher levels of plasma F2-isoprostanes ...on UCP2 genotypes groups, we did detect an association of MPO levels and ...
8
Effect of speed endurance training and reduced training volume on running economy and single muscle fiber adaptations in trained runners
... (CS), UCP3 as well as SERCA- and myosin heavy chain (MHC) isoforms in different muscle fiber types, 88 5 single-fiber segments were collected from each freeze-dried muscle ...
12
Compound porcine cerebroside and ganglioside injection attenuates cerebral ischemia–reperfusion injury in rats by targeting multiple cellular processes
... to polyvinylidene fluoride membranes. The membranes were blocked in 5% nonfat milk for 1 hour at room temperature and then incubated overnight at 4 ° C with the desired primary antibodies: rabbit anti-GADD45 α (1:1,000; ...
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The Preservation of in vivo Phosphorylated and Activated Uncoupling Protein 3 (UCP3) in Isolated Skeletal Muscle Mitochondria following Administration of 3,4 Methylenedioxymethamphetamine (MDMA aka Ecstasy) to Rats/Mice
... mitochondrial UCP3 is one of those proteins phosphorylated in vivo, on serine(s) and tyrosine(s) (but not threonine) following treatment of animals with MDMA (Figure ...4). UCP3 phosphorylation is not ...
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The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism
... Opposite effects of feeding a vitamin A-deficient diet and retinoic acid treatment on brown adipose tissue uncoupling protein 1 (UCP1), UCP2 and leptin expression. In vitro and in vivo[r] ...
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Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes
... and UCP3 in mus- cle cells alone, or in muscle cells pretreated with condi- tioned medium previously collected from adipocyte culture or co-cultured with muscle ...
8
Correlation of sTREM-1 content with hepatic fibrosis, inflammatory response and oxidative stress response in hepatic infective ascites
... (pg/mL), UCP2 (pg/mL), iNOS (pg/mL) and NO (nmol/mL) in ascites among the three groups of subjects was as follows: MDA, NOX1, UCP2, iNOS and NO contents in ascites of infection group and non-infection group ...
5
ACE and UCP2 gene polymorphisms and their association with baseline and exercise related changes in the functional performance of older adults
... While considerable heterogeneity exists in the physical function of many older adults, even when chronic conditions and medications are controlled for, the relative contribution of genetics and long-term physical ...
18
Uncoupling protein 2 gene polymorphisms are associated with obesity
... In the Balinese population studied, we observed that urban subjects with A/A genotype of the SNP G(−866)A has higher BMI than rural subjects with the same genotype, suggesting the important role of the environment. ...
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Original Article Effect of epigallocatechin gallate on uncoupling protein 2 in acute liver injury
... Abstract: Background: The aim of this study was to investigate the effect of epigallocatechin gallate (EGCG) on uncoupling protein 2 regulation in an acute liver injury-animal model. Methods: Twenty seven male Wistar ...
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