uncoupling protein
Mitochondrial uncoupling protein 1 overexpression increases yield in Nicotiana Tabacum under drought stress by improving source and sink metabolism
... Overexpression of plant mitochondrial uncoupling protein in transgenic tobacco increases tolerance to oxidative stress.. Activation and function of mitochondrial uncoupling protein in pl[r] ...
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Original Article Effect of epigallocatechin gallate on uncoupling protein 2 in acute liver injury
... on uncoupling protein 2 regulation in an acute liver injury-animal ...of uncoupling protein 2, CRP, TNF-α and interleukins (IL) 6 and 18 were analyzed in the liver using PCR ...down-regulates ...
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The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study
... [1]. Uncoupling protein 2 (UCP2) inhib- its glucose stimulated insulin secretion, and models of type 2 diabetes are associated with increased expression in islets ...the uncoupling protein ...
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Uncoupling protein 2 regulates myocardial apoptosis via the diabetogenic action of streptozotocin
... of uncoupling protein 2 (UCP2) in the myocardial apoptosis of diabetic melli- tus （ DM ） ...relative protein for myocardial apoptosis, pro-caspase-9, were investigated using western ...pro-caspase-9 ...
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Inhibition of uncoupling protein 2 with genipin exacerbates palmitate-induced hepatic steatosis
... The current concept suggests that the oxidative stress plays an important role in the development of hepatic steatosis. UCP2, a well-established uncoupling protein, has been viewed as an inhibitor of ...
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Reptilian uncoupling protein: functionality and expression in sub zero temperatures
... reptilian uncoupling protein (repUCP) gene from the European common lizard ( Lacerta vivipara ...the protein shows 55%, 72% and 77% sequence homology with rat UCP1, UCP2 and UCP3, respectively, and ...
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Uncoupling protein 2 gene polymorphisms are associated with obesity
... the uncoupling protein 2 (UCP2), a transporter protein present in the mitochondrial inner membrane (UniProt accession P55851) ...via uncoupling of the substrate oxi- dation from ATP synthesis, ...
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Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells
... Decreased uncoupling protein (UCP)3 is associated with insulin resistance in muscle of pre-diabetic and diabetic individuals, but the function of UCP3 remains ...mitochondrial uncoupling and reactive ...
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Uncoupling protein 2 polymorphisms as risk factors for NTDs
... women. Uncoupling Protein 2 (UCP2) is an attractive candidate to screen for NTD risk because of its possible role in obesity as well as energy metabolism, type-2 diabetes, and the regulation of reactive ...
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Involvement of Drosophila Uncoupling Protein 5 in Metabolism and Aging
... A novel uncoupling protein, UCP5, has recently been characterized as a functional mitochondrial uncoupler in Drosophila. Here we demonstrate that UCP5 knockout (UCP5KO) flies are highly sensitive to ...
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An investigation into the physiological expression and function of mitochondrial uncoupling protein 1 in thymus
... In our endeavours to understand the role of mitochondrial uncoupling protein 1 in thymocyte function, we compared cell profiles in thymus and spleen of wild-type mice with those of UCP 1[r] ...
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Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice
... Mitochondrial uncoupling protein 3 (UCP3) is consituitively expressed in mitochondria from thymus and spleen of mice, and confocal microscopy has been used to visualize UCP3 in situ in mouse ...UCP3 ...
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Superoxide mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction
... phenomenon that includes loss of glucose sensing, resulting in impairment of glucose-stimulated insulin secretion (GSIS); increased basal insulin secretion; decreased islet insulin content; altered gene transcrip- tion; ...
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Overexpression of uncoupling protein 3 in skeletal muscle protects against fat induced insulin resistance
... muscle. Uncoupling protein 3 (UCP3) has been postulated to dissipate the mitochondrial proton gradient and cause metabolic ...mitochondrial uncoupling in skeletal muscle may be an excellent ...
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The role of uncoupling protein 3 in human physiology
... by uncoupling protein 1 (UCP1) (previously known as uncou- pling protein or thermogenin), first cloned in 1985 ...additional uncoupling proteins with broader tissue expression, and two other ...
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Mitochondrial uncoupling protein 1 expression in thymocytes
... mitochondrial uncoupling protein 1 (UCP1) peptide, this study confirms the observation that UCP 1 is present in thymocytes isolated from UCP 1 wild-type, but not UCP 1 knock-out ...1 protein appears ...
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Increased uncoupling protein 2 and 3 mRNA expression during fasting in obese and lean humans
... Uncoupling protein-2 and -3 (UCP2 and UCP3) are mito- chondrial proteins that show high sequence homology with the brown adipocyte–specific ...by uncoupling respiration from ATP ...
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Association Between Uncoupling Protein 3 Gene and Obesity-Related Phenotypes in the Québec Family Study
... It has been shown that UCP3, like UCP1, has an uncoupling function and increases thermogenesis in transfected cells (9), although its physiologic role is not known. Other potential roles for UCP3 in the regulation ...
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Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5
... The prefrontal cortex from both hemispheres were homog- enized using a tight pestle with 7 volumes of lysis buffer (10 mM HEPES pH 7.9, 1.5 mM MgCl 2 , 10 mM KCl, 12% glycerol, 0.1 mM EGTA, 0.5 mM DTT, and 0.5 mM ...
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The Role of Mitochondrial Uncoupling Protein 3 in T Cell Function
... The uncoupling activity of UCP1 is subsequently stimulated by the presence of FFAs (which can also serve as fuel) and long-chain fatty acyl CoA esters, causing thermogenesis (Figure ...UCP1 uncoupling ...
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