Uncoupling protein 3 (UCP3)
Overexpression of uncoupling protein 3 in skeletal muscle protects against fat induced insulin resistance
... muscle. Uncoupling protein 3 (UCP3) has been postulated to dissipate the mitochondrial proton gradient and cause metabolic ...of UCP3 in skeletal muscle might protect against fat- ...
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Alterations in proton leak, oxidative status and uncoupling protein 3 content in skeletal muscle subsarcolemmal and intermyofibrillar mitochondria in old rats
... and uncoupling protein 3 (UCP3) content, since it has been demonstrated that this protein plays a role in the defence of mitochondria from oxidative damage ...
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The Preservation of in vivo Phosphorylated and Activated Uncoupling Protein 3 (UCP3) in Isolated Skeletal Muscle Mitochondria following Administration of 3,4 Methylenedioxymethamphetamine (MDMA aka Ecstasy) to Rats/Mice
... Uncoupling protein 3 (UCP3) was first discovered by Boss et ...characterized uncoupling protein, UCP1, found in brown adipose tissue (Nicholls and Locke, 1984; Cannon and ...
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Association Between Uncoupling Protein 3 Gene and Obesity-Related Phenotypes in the Québec Family Study
... observed UCP3 association with leptin might be secondary to fat ...the UCP3 gene did not induce an obesity phenotype ...of UCP3, as in knockout mice, would induce compensatory mechanisms in contrast ...
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Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo
... and UCP3; thus, untreat- ed cells failed to show any detectable ...human UCP3 (hUCP3), a punc- tate mitochondrial staining appeared, which was completely abolished after preincubation of the anti- body with ...
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Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
... both UCP3 polymorphisms arose on the African continent and genotype frequencies have remained undisturbed in the two related ...and UCP3 in obese and lean individuals increase ...alter UCP3 function ...
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The Role of Mitochondrial Uncoupling Protein 3 in T Cell Function
... for 3 min using a microwave, until ...dye. 3 µL of the GeneRuler™ DNA Ladder Mix and 8 µL of samples were loaded onto the ...and Ucp3 genotyping are displayed in Appendix ...
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Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice
... fasting, UCP3 protein expression is increased in mitochondria isolated from the thymus, but not spleen mitochondria of 129 wild-type mice when compared to fed ...The UCP3 peptide antibody detects ...
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Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells
... Decreased uncoupling protein (UCP)3 is associated with insulin resistance in muscle of pre-diabetic and diabetic individuals, but the function of UCP3 remains ...between UCP3 and ...
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The role of uncoupling protein 3 in human physiology
... by uncoupling protein 1 (UCP1) (previously known as uncou- pling protein or thermogenin), first cloned in 1985 ...additional uncoupling proteins with broader tissue expression, and two other ...
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Post genomic approaches to understanding the mechanisms of environmentally induced phenotypic plasticity
... In order to explore the mechanisms underpinning this response we searched for other sets of muscle genes that showed the opposite response in the cold, that is genes whose mRNA levels increased in skeletal muscle during ...
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Uncoupling protein 2 gene polymorphisms are associated with obesity
... The data exploration and analysis was performed by util- izing custom scripts for data preprocessing and R statis- tical packages employing genetics, rms and haplo.stats libraries. Continuous variables were shown as mean ...
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Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3 adrenergic agonist
... UCP protein. To determine whether the UCP protein is present not only in adipose tissues but also in skeletal muscle, a crude fat-free extract of the tissue was ap- plied to Western blot ...Fig. 3, a ...
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Reptilian uncoupling protein: functionality and expression in sub zero temperatures
... endotherms (5–10 times) compared to ectotherms (Berner, 1999; Brand et al., 1991) and (2) that mitochondria from ectotherms are less leaky to proton than those from endotherms (Brand et al., 1991; Brookes et al., 1998). ...
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Uncoupling protein 2 polymorphisms as risk factors for NTDs
... women. Uncoupling Protein 2 (UCP2) is an attractive candidate to screen for NTD risk because of its possible role in obesity as well as energy metabolism, type-2 diabetes, and the regulation of reactive ...
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UCP2 and UCP3 in muscle controlling body metabolism
... mild uncoupling could prevent a large increase in the mitochondrial proton gradient in situations in which no ADP is available for ATP synthesis and that this mild uncoupling could prevent the mitochondrial ...
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Mitochondrial uncoupling protein 1 overexpression increases yield in Nicotiana Tabacum under drought stress by improving source and sink metabolism
... Overexpression of plant mitochondrial uncoupling protein in transgenic tobacco increases tolerance to oxidative stress.. Activation and function of mitochondrial uncoupling protein in pl[r] ...
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Vitamin D3/VDR resists diet-induced obesity by modulating UCP3 expression in muscles
... respiration uncoupling are implicated in nu- merous physiological and pathological processes, includ- ing adaptive thermogenesis [36], regulation of fatty acid oxidation [37], and body weight regulation ...[38]. ...
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Dietary long-chain, but not medium-chain, triglycerides impair exercise performance and uncouple cardiac mitochondria in rats
... cardiac UCP3 expression in sedentary rats, whereas the MCT-rich diet did not [12], and here we have extended this finding to exercised ...the UCP3 inhibitor, ...
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Anti-obesity effect of the CB2 receptor agonist JWH-015 in diet-induced obese mice
... This experiment was conducted in order to determine the dose of JWH-015 most effective in suppressing food intake. Specifically, 8 week-old male C57BL/6J mice (Animal Resource Cen- tre, Perth; N = 10) were individually ...
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