UNTRANSLATED REGION
The U Rich Untranslated Region of the Hepatitis E Virus Induces Differential Type I and Type III Interferon Responses in a Host Cell Dependent Manner
... 3= untranslated region (UTR) of the HEV genome induced higher levels of IFN mRNA, interferon regulatory factor-3 (IRF3) phosphorylation, and nuclear translocation than the 5= UTR of ...U-rich region ...
15
Comparative performance evaluation of hepatitis C virus genotyping based on the 5' untranslated region versus partial sequencing of the NS5B region of brazilian patients with chronic hepatitis C
... NS5B region or other coding regions of the HCV gen- ome ...geographical region, genotype identification based on 5’UTR may be unreli- able because some genotype 6 variants that have been found in Southeast ...
5
The Pseudoknot Region of the 5′ Untranslated Region Is a Determinant of Viral Tropism and Virulence of Foot-and-Mouth Disease Virus
... 5= untranslated region (UTR) plays an important role during FMDV ...PK region is predicted to be involved in the conserved structures of the FMDV genome ...PK region remains largely unknown ...
17
Identification of nuclear and cytoplasmic proteins that interact specifically with an AU-rich, cis-acting inhibitory sequence in the 3' untranslated region of human papillomavirus type 1 late mRNAs.
... * untranslated region of human papillomavirus type 1 late ...* untranslated region of human papillomavirus type 1 early mRNAs, which does not show inhibitory ...
9
A nuclear factor binding domain in the 5' untranslated region of the amyloid precursor protein promoter: Implications for the regulation of gene expression
... UTR: untranslated region; CAT: chloramphenicol acetyltransferase; DTT: dithiothreitol; CHAPS: 3 [(3- cholamidopropyl)dimethylammonio]-propanesulfonic acid; Hepes: N-2- Hydroxyethylpiperazine-N ’ ...
6
Suppression of a Nuclear aep2 Mutation in Saccharomyces cerevisiae by a Base Substitution in the 5′-Untranslated Region of the Mitochondrial oli1 Gene Encoding Subunit 9 of ATP Synthase
... oli1 region of mtDNA using rho 2 genetic mapping techniques coupled with PCR analysis; DNA sequencing revealed, in each case, a T-to-C nucleotide transition in mtDNA 16 nucleotides upstream of the oli1 reading ...
12
Characterization of an Essential RNA Secondary Structure in the 3′ Untranslated Region of the Murine Coronavirus Genome
... We have previously identified a functionally essential bulged stem-loop in the 3 ⴕ untranslated region of the positive-stranded RNA genome of mouse hepatitis virus. This 68-nucleotide structure is composed ...
11
Mitochondrial Aconitase Binds to the 3′ Untranslated Region of the Mouse Hepatitis Virus Genome
... Mouse hepatitis virus (MHV), a member of the Coronaviridae, contains a polyadenylated positive-sense single-stranded genomic RNA which is 31 kb long. MHV replication and transcription take place via the synthesis of ...
11
The 3' untranslated region of picornavirus RNA: features required for efficient genome replication.
... * untranslated region (3 * UTR) in the replication of enteroviruses has been studied with a series of mutants derived from either poliovirus type 3 (PV3) or a PV3 replicon containing the reporter gene ...
10
An RNA tertiary structure in the 3' untranslated region of enteroviruses is necessary for efficient replication.
... Enteroviruses make up one genus of the Picornaviridae, a diverse family of small viruses including several of clinical or economic importance such as polioviruses, hepatitis A virus, rhinoviruses (the major cause of the ...
8
The 5′ Untranslated Region of the Major Immediate Early mRNA Is Necessary for Efficient Human Cytomegalovirus Replication
... ABSTRACT The human cytomegalovirus (HCMV) immediate early 1 (IE1) and IE2 proteins are critical regulators of virus replication. Both proteins are needed to effi- ciently establish lytic infection, and nascent expression ...
14
Nucleotide Variability and Translation Efficiency of the 5′ Untranslated Region of Hepatitis A Virus: Update from Clinical Isolates Associated with Mild and Severe Hepatitis
... ⬘ untranslated region (5 ⬘ UTR), a single open reading frame that encodes both structural and nonstructural proteins, and a 3 ⬘ UTR with a short poly(A) ...
9
Prevalence of thymidylate synthase gene 5'-untranslated region variants in an Argentinean sample.
... The mRNA expression of the TYMS gene is thought to be affected by a 28-bp tandem repeat polymorphism within its 5'-untranslated region (UTR; Kaneda et al., 1987). The majority of human TYMS alleles harbor ...
7
The non-primate hepacivirus 5 ' untranslated region possesses internal ribosomal entry site activity
... 9 untranslated region (5 9 UTR) of the recently described non-primate hepacivirus (NPHV) contains a region with sequence homology to the internal ribosomal entry site (IRES) of hepatitis C virus ...
8
Roles of the 5′ Untranslated Region of Nonprimate Hepacivirus in Translation Initiation and Viral Replication
... Efficiency of EHcV IRES activity. Comparison of the complete nucleotide sequence of the EHcV 5= UTR (strain JPN3; GenBank accession no. AB863589.1) with that of the HCV 5= UTR (strain JFH1; GenBank accession no. ...
18
The 5′ Untranslated Region of Human Bocavirus Capsid Transcripts Regulates Viral mRNA Biogenesis and Alternative Translation
... unique region (VP1u) sequence with (pT7-R6, pT7-R7, and pT7-R8) or without (pT7-VP1) the 5= UTR of the R6, R7, and R8 transcripts were inserted into a PCR-BluntII-TOPO vector that contained a 27-nt A tract to ...
16
The plausible reason why the length of 5' untranslated region is unrelated to organismal complexity
... fishes) or invertebrate species. Furthermore, the source of the increased regulatory complexity in complex organisms has not been fully explained, although the elongation of 5’ untranslated regions (5’UTRs) has ...
12
Influence of Theiler's murine encephalomyelitis virus 5' untranslated region on translation and neurovirulence.
... Our previous results from chimeric cDNA studies had indicated that GDVII 1B-2C has a major role in determining neurovirulence but that the addition of GDVII sequences 5' to this also con[r] ...
10
Cap-independent translation by the 5' untranslated region of Theiler's murine encephalomyelitis virus.
... Comparison of the Cat and Luc activities expressed by the various bicistronic mRNAs both in transfected cells and in in vitro translation reactions strongly suggests that the TMEV 5'UTR [r] ...
8
Structural Domains within the 3′ Untranslated Region of Turnip Crinkle Virus
... loop region of helix H5 lead to its distortions away from the helical form, and, past the ...loop region and the resulting bending of the entire H5 helix follow the movements of this ...
15