untranslated regions
Untranslated regions of mRNAs
... ated by cis-acting elements located in the 3 UTR, but there are also examples of elements in the 5 UTR or even in the coding sequence; these are known as mRNA zip codes and interact with zip-code-binding proteins (such ...
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Role of the 3′-Untranslated Regions of Alfalfa Mosaic Virus RNAs in the Formation of a Transiently Expressed Replicase in Plants and in the Assembly of Virions
... -untranslated regions (UTRs) of both RNAs deleted (R1 ⌬ /2 ⌬ construct), no replication of RNAs 1 and 2 was observed, while the infiltrated leaves supported replication of RNA 3 after inoculation of the ...
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Dengue and Zika Virus 5′ Untranslated Regions Harbor Internal Ribosomal Entry Site Functions
... ABSTRACT The Flavivirus genus of the Flaviviridae family encompasses numerous enveloped plus-strand RNA viruses. Dengue virus (DENV), a flavivirus, is the leading cause of serious arthropod-borne disease globally. The ...
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Characterization of untranslated regions of the salmonid alphavirus 3 (SAV3) genome and construction of a SAV3 based replicon
... and E1. The second ORF is transcribed from an anti-sense genome under the control of a subgenomic promoter in the untranslated region that separates the two ORFs [4,5]. The genome is replicated by the nsPs, which ...
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Bunyamwera Orthobunyavirus S-Segment Untranslated Regions Mediate Poly(A) Tail-Independent Translation
... The mRNAs of Bunyamwera virus (BUNV), the prototype of the Bunyaviridae family, possess a 5 ⴕ cap structure but lack a 3 ⴕ poly(A) tail, a common feature of eukaryotic mRNAs that greatly enhances translation efficiency. ...
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Improving plant transient expression through the rational design of synthetic 5′ and 3′ untranslated regions
... ′ untranslated regions (UTRs) as enhancers of expression, there have, to our knowledge, been no systematic attempts to cre- ate synthetic UTRs de ...
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Modification of the Untranslated Regions of Human Enterovirus 71 Impairs Growth in a Cell-Specific Manner
... three regions: P1 encodes structural proteins, and P2 and P3 encode nonstructural proteins ...3= untranslated regions (UTR), with a poly(A) tail at the 3= terminus of the 3= UTR (reviewed in ...
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The 5'-untranslated regions of picornavirus RNAs contain independent functional domains essential for RNA replication and translation.
... 4384-4391 0022-538X/94/$04.00+0 Copyright © 1994, American Society for Microbiology JOURNAL OF VIROLOGY, The 5'-Untranslated Regions of Picornavirus RNAs Contain Independent Functional D[r] ...
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Attenuation of Bunyamwera Orthobunyavirus Replication by Targeted Mutagenesis of Genomic Untranslated Regions and Creation of Viable Viruses with Minimal Genome Segments
... Bunyamwera virus (BUNV) is the prototype virus for both the genus Orthobunyavirus and the family Bunyaviridae. BUNV has a tripartite, negative-sense RNA genome. The coding region of each segment is flanked by ...
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Role of Untranslated Regions in Regulation of Gene Expression, Replication, and Pathogenicity of Newcastle Disease Virus Expressing Green Fluorescent Protein
... of untranslated regions (UTRs) in regulation of foreign gene expression, replication, and pathogenicity of Newcastle disease virus (NDV), a green fluorescent protein (GFP) gene flanked by 5 ⴕ and 3 ⴕ UTRs ...
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Long Untranslated Regions of the Measles Virus M and F Genes Control Virus Replication and Cytopathogenicity
... Measles is still a major cause of mortality mainly in developing countries. The causative agent, measles virus (MeV), is an enveloped virus having a nonsegmented negative-sense RNA genome, and belongs to the genus ...
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Mutational Analyses of the Nonconserved Sequences in the Bunyamwera Orthobunyavirus S Segment Untranslated Regions
... complementary untranslated regions (UTRs) flank the coding region of each ...internal regions are unique to each segment and largely nonconserved between different ...internal regions of both ...
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Genomewide Mapping and Screening of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) 3′ Untranslated Regions Identify Bicistronic and Polycistronic Viral Transcripts as Frequent Targets of KSHV MicroRNAs
... 3= untranslated regions (3=UTRs) of target transcripts, have recently emerged as key regulators of KSHV life ...coding regions of bicistronic or polycistronic transcripts and highlight the unique ...
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Functional equivalence of common and unique sequences in the 3' untranslated regions of alfalfa mosaic virus RNAs 1, 2, and 3.
... * untranslated regions (UTRs) of alfalfa mosaic virus (AMV) RNAs 1, 2, and 3 consist of a common 3 * -terminal sequence of 145 nucleotides (nt) and upstream sequences of 18 to 34 nt that are unique for each ...
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Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions
... specific regions of the target mRNAs, their coverage of the transcripts is essentially incomplete and too sparse to use them as positional markers for direct estimation of the transcripts’ ...
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Genotyping Hepatitis C Viruses from Southeast Asia by a Novel Line Probe Assay That Simultaneously Detects Core and 5′ Untranslated Regions
... core regions of the HCV genome, utilizing the primers HCVPr95 AT&AC, HCVPr96b, HCVPr769b, and HCVPr822b, generating two distinct PCR products from 5⬘UTR and core re- gions, ...
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Sequence and translation initiation properties of the xenopus TGFbeta5, PDGF A, and PDGF alpha receptor 5' untranslated regions
... VanderVelden1362 pm 1 Xenopus TGF, PDGF and PDGF receptor 5?UTRs 851 Original Article Sequence and translation initiation properties of the Xenopus TGF?5, PDGF A, and PDGF ? receptor 5' untranslated r[.] ...
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hnRNP A1 Interacts with the 5′ Untranslated Regions of Enterovirus 71 and Sindbis Virus RNA and Is Required for Viral Replication
... ⴕ untranslated region (UTR) of enterovirus 71 (EV71) and regulates IRES-dependent translation but also binds to the 5 ⴕ UTR of Sindbis virus (SV) and facilitates its ...
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Functional SNPs within Exons and 3-untranslated regions of PAH gene associated with Phenylketonuria: using bioinformatics methods
... PAH gene within dbSNP, where green column shows 25.5% total Homo sapiens SNPs of all species SNPs, in addition red column (11.4%) non-synonymous and blue column (0.7%) 3UTR SNPs of total Homo sapiens. Total SNPs contain ...
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FUSE Binding Protein 1 Interacts with Untranslated Regions of Japanese Encephalitis Virus RNA and Negatively Regulates Viral Replication
... A protein band with a molecular mass of around 72 kDa was pulled down by the biotin-UTR-Luc RNA (Fig. 1A). LC- MS/MS data indicated that 11 of the identified peptides had an amino acid sequence matching different ...
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