uPA/PAI-1
Kazik, Martin Franz (2019): Prognostische Bedeutung disseminierter Tumorzellen und uPA/PAI-1 beim Mammakarzinom. Dissertation, LMU München: Medizinische Fakultät
... des uPA/PAI-1 Systems fernab des Primärtumors ...dass uPA/PAI-1 Proteasen nicht nur Effekte auf Migration und Dissemination haben, sondern auch in der Lage sind, für ...
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Levels of uPA and PAI-1 in breast cancer and its correlation to Ki67-index and results of a 21-multigene-array
... negative uPA/PAI-1 than with increased values, with the threshold between low and high Ki67 be- ing set at 20% ...for uPA/PAI-1 is only possible on fresh or frozen tumour tissue; ...
8
uPA and PAI 1 as biomarkers in breast cancer: validated for clinical use in level of evidence 1 studies
... measure uPA and PAI-1 in research ...of uPA detected, however, varied between the different ...for uPA and between 5.4% and 5.8% for PAI-1 ...detect uPA levels in ...
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Common TNF α, IL 1β, PAI 1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis
... and PAI-1 by allele specific PCR as described [17]. uPA, TLR4, and CD14 were analyzed using a microsphere based assay (Luminex 100, Luminex ...(Table 1) were synthesized and modified at the 5' ...
7
Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells
... by uPA-mediated activation of plasmin and subsequent degradation of extracellular matrix ...[21]. PAI-1 is the unique and specific inhibitor of both tPA and uPA [22] and thus expected to ...
15
Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin
... and PAI-1 regulate adhesion and migration of cells independently of, though influenced by, urokinase, implies an intrinsic duality of the uPA/plasmin sys- ...of uPA and plasmin are ...
11
Protease nexin-1 expression is altered in human breast cancer
... both PAI-1 [24-26] and uPA [24,26] expression levels are known to be elevated in metastatic breast cancer, we measured their levels in our 26 tumor samples for direct comparison with PN-1 ...
7
"Hypoxia induced down regulation of microRNA 449a/b impairs control over targeted SERPINE1 (PAI 1) mRNA a mechanism involved in SERPINE1 (PAI 1) overexpression"
... b 1-3) and bone morphogenetic proteins (BMPs) ...bitor-1, PAI-1) is an inhibitor of plasmin action and was shown to be a target of TGF b -1 which implicates cross- talks between the ...
14
Bleomycin induced pulmonary fibrosis in fibrinogen null mice
... of PAI-1 deficiency on pulmonary fibrosis could also be due to nonproteolytic features of the plasminogen activator/plasmin ...of PAI-1 to the extracellular matrix protein vitronectin reduces ...
11
High Concentrations of Plasminogen Activator Inhibitor-1 in Lungs of Preterm Infants With Respiratory Distress Syndrome
... nary PAI-1 and a high ratio of PAI-1 to uPA during the early postnatal days for preterm infants with ...RDS. PAI-1 levels were associated strongly with the severity of ...
11
Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression
... of uPA secretion was associated with the LPS-induced suppression of TNF, PAI-1 and ...MIP-2. uPA is under the tight control of its inhibitor, PAI-1 ...[44]. PAI-1 ...
11
Plasminogen Activator Inhibitor-1 is Regulated Through Dietary Fat Intake and Heritability: Studies in Twins
... active PAI-1 plasma levels but not PAI-1 mRNA expression in adipose tissue are influenced by insulin levels and ...that PAI-1 concentrations in plasma are at least in part ...
11
Tumor necrosis factor receptor 1 (TNFRI) for ventilator-associated pneumonia diagnosis by cytokine multiplex analysis
... least 1 potentially pathogenic microorganism (PPM) in respiratory samples above predefined thresholds (for bronchoalve- olar lavage specimens, >104 CFU/mL; for sputum or tracheobronchial aspirate specimens, 105 ...
11
Mouse aortic ring assay: A new approach of the molecular genetics of angiogenesis
... Angiogenesis was studied by culturing rings of mouse aorta in three-dimensional collagen gels with some modifications of the method originally reported for the rat aorta (4). Thoracic aortas were removed from mice ...
8
Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence
... Cellular senescence was first described in a study examining the proliferative potential of diploid fibroblasts that had been isolated from human fetal tissue. In this study Hayflick and Moorehead described the ...
10
Cytokines induce urokinase dependent adhesion of human myeloid cells A regulatory role for plasminogen activator inhibitors
... alpha. uPA-dependent adhesiveness was reversible after 24 h of stimulation with cytokines and uPA as adherence was prevented by the subsequent addition of anti-uPA ...
13
Plasminogen Activator Inhibitor-1 (PAI-1) deficiency predisposes to depression and resistance to treatments
... of PAI-1 knockout (PAI-1 − / − ) and wild-type (PAI-1+/+) male mice with a range of behavioral tests assessing depressive-like behaviors ( n = ...relating PAI-1 to ...
12
synergistically increase PAI-1 expression in hepatic stellate cells of rats
... TGF-β 1 expression and activation, leading to the increase in PAI-1 expression, and TGF-β 1 neutralizing antibody may reduce the Ald induced PAI-1 expression, but it may not ...
9
Significant associations of PAI 1 genetic polymorphisms with osteonecrosis of the femoral head
... plasma PAI-1 levels are highest in ONFH patients with the 4G/4G genotype, but that the incidence of ONFH is not related to genotype ...of PAI-1 on ONFH, we selected SNPs in the promoter and ...
7
Lipoatrophy of the footpad in HIV-treated patients is associated with increased PAI-1
... Comparisons regarding the ART patients' and the ART naïve control patients' demographic, clinically and metabolic characteristics at follow-up are shown in Table 1. Not surprisingly, the ART patients were older ...
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