uPA/uPAR
Effects of ulinastatin and docetaxel on breast cancer invasion and expression of uPA, uPAR and ERK
... that uPA, uPAR and p-ERK expression is obviously inhibited by ...of uPA, uPAR and ERK1/2, its cell toxicity still plays a dominant role, so when treated with docetaxel alone, the proliferation ...
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Antibody-based PET of uPA/uPAR signaling with broad applicability for cancer imaging
... vivo uPA targeting [20]. Compared with other uPA-targeted antibodies, ATN- 291 used in this study is unique in at least three aspects: it has an extremely high affinity for its target (K d : ~ ...with ...
13
uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy
... of uPAR is associated with an invasive and metastatic phenotype in studies done using in vivo murine models of head and neck ...of uPAR reduces tumor growth and downregulates the expression of genes ...
16
Inhibitory effect of ethanol extract of Ocimum sanctum on osteopontin mediated metastasis of NCI H460 non small cell lung cancer cells
... for uPA, uPAR and EGFR, Western blotting for osteopontin (OPN), and CD44, ELISA for VEGF and PI3K/Akt inhibitor LY294002 study in OPN treated NCI-H460 non-small cell lung cancer ...
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Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor
... of uPAR in uPA-mediated plasminogen activation during liver repair, mice were challenged with a single dose of CCl 4 ...of uPAR or plas- minogen activator (Figure 1). Interestingly, uPA° mice ...
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Clinical significance of the uPA system in gastric cancer with peritoneal metastasis
... the uPA receptor (uPAR) on the surface of the tumor ...cell-bound uPA is capable of converting plasminogen into plasmin, which is then able to degrade several com- ponents of the extracellular matrix ...
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Coordinate regulation of fibronectin matrix assembly by the plasminogen activator system and vitronectin in human osteosarcoma cells
... In addition to binding to uPA/uPAR complexes, PAI-1 also binds directly to matrix vitronectin. To determine whether the effects of PAI-1 on matrix assembly required vitronectin, MG-63 cells were seeded ...
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Original Article Urokinase-type plasminogen activator protects human umbilical vein endothelial cells from apoptosis in sepsis
... by uPA, and cell viability, apoptosis, TNF-α, IL-6, GMCSF and uPAR levels were evaluated by CCK-8, AV/PI, qPCR, western blot and ELISA, ...Subsequently, uPA shRNA was transferred into septic HUVECs, ...
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TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation
... in uPA-induced cell migration, LMW-uPA lacking the uPAR binding domain was added to various tumor cells to stimulate ...the uPAR-independent migration of HepG2 hepatoma cells; this activity ...
16
The urokinase receptor is required for human monocyte chemotaxis in vitro
... to uPAR completely ablates chemotaxis, but blocking uPA expression with an antisense oligonucleotide to uPA has a minimal ...of uPAR plays an obligate role in M phi chemotaxis by mechanisms ...
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Analysis of Lipoprotein(a) Receptors: Roles in Catabolism and Pericellular Plasminogen Activation
... the uPAR in the plasminogen activation system. The uPAR functions by binding to pro-uPA or active uPA to accelerate plasminogen ...to uPAR followed by plasmin cleavage of pro-uPA ...
255
First-in-human uPAR PET: Imaging of Cancer Aggressiveness
... higher uPA activity and markedly increased expression of uPAR in the rheu- matoid arthritis synovial tissue, especially at the marginal zone between pannus and ...that uPAR PET imaging could also be ...
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Shear stress modulates macrophage induced urokinase plasminogen activator expression in human chondrocytes
... (tPA), uPA receptor (uPAR), and PA inhibitor-1 (PAI-1). uPA is a 55-kDa serine protease, which is released as an inactive single-chain zymogen ...receptor, uPAR, pro-uPA is activated ...
13
Targeting of surface alpha-enolase inhibits the invasiveness of pancreatic cancer cells
... anti-human uPAR polyclonal antibody (10µg/ml; Santa Cruz Biotechnology by ...of uPA, cells were fixed with 4% paraformaldehyde (20 min at room temperature (RT) and then permeabilized with 5% ...anti-human ...
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Enhancement of cutaneous wound healing by Dsg2 augmentation of uPAR secretion
... including uPA and uPAR (Werner and Grose, 2003). There was increased uPAR expression in the epidermis and secretion into the dermis of the K14-Dsg2 mice as well as the actively proliferating and ...
34
A ligand free, soluble urokinase receptor is present in the ascitic fluid from patients with ovarian cancer
... of uPAR from the ascitic fluids by ligand-affinity chromatography (pro-uPA Sepharose), the uPAR was initially identified by cross-linking to a radiolabeled amino-terminal fragment of human ...The ...
9
Enhanced bioreduction-responsive diselenide-based dimeric prodrug nanoparticles for triple negative breast cancer therapy
... a uPAR ligand, uPA peptide (sequence: VSNKYFSNIHW) [34], was covalently anchored onto the PTXD-Se NPs surface to achieve TNBC-targeting capability in vivo through binding with ...
14
Original Article Co-expression of uPAR and CXCR4 promotes tumor growth and metastasis in small cell lung cancer
... of uPAR and CXCR4 on small cell lung cancer (SCLC), the most aggressive type of lung cancer, is not ...of uPAR and CXCR4 in SCLC tissue samples (n = 50) by ...both uPAR and CXCR4 (12/50) had larger ...
10
Expression of Urokinase Plasminogen Activator Receptor on Monocytes from Patients with Relapsing-Remitting Multiple Sclerosis: Effect of Glatiramer Acetate (Copolymer 1)
... The pathogenesis of multiple sclerosis (MS) is a complex, multicellular process in which the infiltration of both mono- cytes and lymphocytes plays a key role (34, 39). Despite con- siderable experimental evidence and ...
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UPA 1 Government Kashmir Issue
... the UPA-I though that alliance emerged as the Single targest coalition with the congress winning 153 seats and other coalition parties together 78 in the 2004 general election, it still needed the support of a new ...
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