Urokinase and the uPA Receptor
ORIGINAL ARTICLE. Expression of Urokinase-type Plasminogen Activator and Its Receptor in Keloids
... The uPA receptor is present in many tissues and has been identified on monocytes, neutrophil granulocytes, leukocytes, endo- thelial cells, macrophages, fibroblasts, and cancer ...
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Nanoparticle Binding to Urokinase Receptor on Cancer Cell Surface Triggers Nanoparticle Disintegration and Cargo Release
... factor receptor (EGFR) [24], transferrin receptor [25], folate receptor [26], integrins [27] and urokinase-type plasminogen activator (uPA) receptor (uPAR) ...candidate ...
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TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation
... As mentioned above, there are three forms of uPA, namely HMW-scuPA, HMW-tcuPA, and LMW-uPA. uPA is initially translated as pro-urokinase containing 431 amino acid residues. After excision of ...
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Role of Urokinase Receptor in Tumor Progression and Development
... of urokinase receptor (uPAR) is detected in various aggressive cancer types and is closely associated with poor prognosis of ...of uPA to uPAR triggers the conversion of plasminogen to plasmin and ...
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The urokinase receptor is required for human monocyte chemotaxis in vitro
... Mononuclear phagocytes (Mphi) produce urokinase-type plasminogen activator (uPA) and also express a specific cell-surface receptor for urokinase, uPAR. The concomitant expression of these ...
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Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis
... The mechanism through which uPAR expression delays the onset of anoikis in cancer cells must be elucidated. uPAR-induced resistance to anoikis in the nontrans- formed retinal epithelial cells resulted from uPA ...
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The urokinase receptor (CD87) facilitates CD11b/CD18 mediated adhesion of human monocytes
... uPAR-associated uPA in modulating CR3- mediated ...between uPA and CR3. In this scenario, uPA may bind to CR3 and alter its adhesive ...brane-associated uPA or plasmin catalytic activities may ...
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Urokinase Plasminogen Activator Receptor (uPAR) Targeted Nuclear Imaging and Radionuclide Therapy
... with uPA, which would make it rather chal- lenging if the imaging probe binds to the same site of uPAR as ...with uPA-uPAR binding, may be advantageous for uPAR-targeted imaging in this ...
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Evaluation of diagnostic value of soluble urokinase-type plasminogen activator receptor in sepsis
... and urokinase PA ...while uPA is mainly involved in peri- cellular matrix degradation during tissue ...of uPA is intensified and localized through binding to a specific cell bound receptor ...
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Receptor-bound urokinase-type plasminogen activator in human colon cancer invasion and metastasis
... This study explores the biological role of receptor-bound uPA in the process of human colon cancer invasion and metastasis an.d the therapeutic potential of uPA [r] ...
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Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia
... the urokinase plasminogen activator receptor (uPAR). Urokinase plasminogen activator (uPA), or a 7-residue peptide derived from this protein (u7-peptide), bound the receptor and ...
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Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor
... of uPA in both uPAR° and uPAR°/tPA° livers underscore the non-essential contribution of uPAR and tPA in the liver- specific plasminogen activation/fibrinolysis during liver ...of uPA to its receptor ...
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Formation of Polyomavirus-Like Particles with Different VP1 Molecules That Bind the Urokinase Plasminogen Activator Receptor
... of urokinase plasminogen activator (uPA) or a related phage display peptide reduced the solubility of VP1 molecules when expressed in insect cells, and insertions into the EF loop reduced VP1 solubility ...
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Urokinase receptor promotes ovarian cancer cell dissemination through its 84-95 sequence
... bind uPA and focus proteolytic activity on cell ...supports uPA-activity at the cell surface, nor binding to vitronectin [18, 28, ...of uPA and becomes able to interact with FPR which, in turn, ...
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Imaging the Urokinase Plasminongen Activator Receptor in Preclinical Breast Cancer Models of Acquired Drug Resistance
... The urokinase plasminogen activator receptor (uPAR) is an attractive target for the development of imaging probes for drug-resistant breast ...protease uPA, uPAR and the inhibitor of uPA, ...
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Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD
... activator receptor (uPAR) is expressed on various cell types, and the complex interac- tion with its ligand urokinase plasminogen activator (uPA) has been shown to promote tissue invasion in ...
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Urokinase Receptor Counteracts Vascular Smooth Muscle Cell Functional Changes Induced by Surface Topography
... observations indicate that on micro-structured sub- strates VSMC reveal elongated morphology and ex- hibit a very strong alignment along the direction of the grooves (Fig. 2B). Expression of both SMA and calponin in VSMC ...
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Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients
... Similarly, limited information on the commercial ELISA used means that we cannot conclude whether both uPA bound and/or free scuPAR were measured in serum. While the subjects in our study were recruited and ...
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Involvement of urokinase receptor in the cross-talk between human hematopoietic stem cells and bone marrow microenvironment
... We now analyze the levels of circulating soluble uPAR forms before and after the myeloablative conditioning regimen preceding HSC transplantation, to identify variations suggesting a possible involvement also in HSC ...
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Prognostic role of urokinase plasminogen activator receptor in gastric and colorectal cancer: a systematic review and meta-analysis
... uPAR, urokinase plasminogen activator receptor; OS, overall survival; CI, confidence ...this receptor is located on chromosome ...of uPA to uPAR orchestrates different signaling molecules that ...
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