urokinase type plasminogen
Interaction between plasminogen activator inhibitor type 1 (PAI 1) bound to fibrin and either tissue type plasminogen activator (t PA) or urokinase type plasminogen activator (u PA) Binding of t PA/PAI 1 complexes to fibrin mediated by both the finger and the kringle 2 domain of t PA
... by urokinase-type plasminogen activator ...by plasminogen activator inhibitor type 1 (PAI-1) that is either present in plasma or bound to fibrin, present in a ...activate ...
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Acceleration of the thrombin inactivation of single chain urokinase type plasminogen activator (pro urokinase) by thrombomodulin
... chain urokinase-type plasminogen activator (scu-PA) by thrombin were investigated by incubating scu-PA with varying concentrations of human thrombin, in both the absence and presence of soluble ...
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Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD
... Soluble urokinase-type plasminogen activator receptor (suPAR) levels increase in acute viral and bacterial infections and in diseases involving chronic ...
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A role for urokinase-type plasminogen activator in human immunodeficiency virus type 1 infection of macrophages.
... Urokinase-type plasminogen activator (uPA), a proteinase which activates plasminogen by cleaving at -CPGR2V-, was shown to cleave the V3 loop in recombinant gp120 of human immunodeficiency ...
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Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma
... elevated urokinase-type plasminogen activator receptor (uPAR; Plaur) expression in rat tissues, which was associated with poor ...of urokinase-type plasminogen activator (uPA; ...
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Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models
... soluble urokinase-type plasminogen activator (uPA) receptor (suPAR) in approximately two-thirds of patients with FSGS, and suPAR levels were predictive of FSGS recur- rence in transplanted kidneys ...
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Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor
... of plasminogen) is able to restore the lobular architecture in a timely ...of plasminogen to implement effective liver repair, plasmin-mediated extracellular pro- teolysis is likely to couple receptor-free ...
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Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report
... In our case, interestingly, α 2AP expression was observed mostly in the corneal stromal opacity area presumably affected with fibrosis and was barely seen in the ulcer- ation area.. Doub[r] ...
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Receptor-bound urokinase-type plasminogen activator in human colon cancer invasion and metastasis
... Statement Acknowledgements Abstract Abbreviations List of Figures CHAPTER 1 INTRODUCTION 1.1 Mechanisms of Tumour Invasion and Metastasis 1.1.1 Major steps in the process of metastasis 1[r] ...
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Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival
... and urokinase type plasminogen activator (uPA), resulting in p27 induction, cell cycle arrest at G1 phase and cell growth suppression in human urothelial carcinoma cell lines expressing ...
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Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase 2 and NAD(P)H oxidase
... tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) protein levels and/or activities without affecting that of uPAR, uPA receptor ...
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Enhanced bioreduction-responsive diselenide-based dimeric prodrug nanoparticles for triple negative breast cancer therapy
... that urokinase-type plasminogen activator receptor (uPAR) plays a major role in invasive cancer cells and also shows high expression in TNBC [32, 33], a uPAR ligand, uPA peptide (sequence: ...
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Current insights into matrix metalloproteinases and glioma progression: transcending the degradation boundary
... Specific Interference of urokinase-type plasminogen activator receptor and matrix metallopro- teinase-9 gene expression induced by double-stranded RNA results in decreased invasion, tu[r] ...
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Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria
... Background: Acute kidney injury (AKI) complicating severe Plasmodium falciparum malaria occurs in up to 40% of adult patients. The case fatality rate reaches 75% in the absence of renal replacement therapy (RRT). The ...
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Organization, evolution and functions of the human and mouse Ly6/uPAR family genes
... Ly6/urokinase-type plasminogen activator receptor-related protein 1 (SLURP1) is expressed in a variety of cells including immune cells [75], sensory neu- rons [76], and epithelial cells [77–80], and ...
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Be Active or Not: the Relative Contribution of Active and Passive Tumor Targeting of Nanomaterials
... Malignant tumor (cancer) remains as one of the deadliest diseases throughout the world, despite its overall mortality drops. Nanomaterials (NMs) have been widely studied as diagnostic and/or therapeutic agents for ...
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UROKINASE RECEPTORS, AND ITS STRUCTURE, SIGNAL TRANSDUCTION AND IMPORTANCE IN ‘PULMONARY RENAL CASCADE’
... Aim: Urokinase is an important and critical enzyme of the Pulmonary renal ...The urokinase-type plasminogen activator (uPA) receptor (uPAR), was identified, isolated and cloned as the plasma ...
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Elevated circulating PAI-1 levels are related to lung function decline, systemic inflammation, and small airway obstruction in chronic obstructive pulmonary disease
... Background: Plasminogen activator inhibitor-1 (PAI-1) and soluble urokinase-type plasminogen activator receptor (suPAR) participate in inflammation and tissue remolding in vari[r] ...
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Factors influencing the cell adhesion and invasion capacity of Mycoplasma gallisepticum
... and plasminogen-binding properties have also been reported for a limited number of Mycoplasma species like ...and plasminogen on adhesion and in- vasion capabilities has been documented ...
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Isolation from human plasma of a plasminogen activator identical to urinary high molecular weight urokinase
... plasmatic plasminogen activators (PA) can be demonstrated after sodium dodecyl sulfate polyacrylamide gel electrophoresis of plasma freshly collected from resting volunteers, followed by transfer of the gels onto ...
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