Uterine Leiomyomas
A rare coincidence of different types of driver mutations among uterine leiomyomas (UL)
... in uterine leiomyomas (UL) that have not been observed to coexist in one tumor and even rarely coexist in different UL tumors of one ...multiple leiomyomas which were studied by cytogenetics, MED12 ...
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GnRH analogs for the treatment of symptomatic uterine leiomyomas
... Abstract Uterine leiomyomas are the most frequent be- nign disease of the female reproductive ...of uterine leiomyomas is lapar- otomic/laparoscopic excision in women who want to preserve ...
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Impact of Genetic Variants in Estrogen Receptor-β Gene in the Etiology of Uterine Leiomyomas
... Estrogens exert their effects on target cells through the activation of estrogen receptors which are classified as nuclear estrogen receptors (ERs) and membrane bound receptors (mERs) (18). The pro- gression of cell ...
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<p>Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas</p>
... 2018, uterine leiomyoma tissues were obtained from 50 patients (the Han nation- ality) with age range ...of uterine myomectomy, subtotal or total ...infections, uterine malignancy and ...of ...
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Cytogenetically normal uterine leiomyomas without MED12-mutations – a source to identify unknown mechanisms of the development of uterine smooth muscle tumors
... uterine leiomyomas. Again a dras- tically reduced ability of some leiomyomas to proliferate in vitro may account for the lack of detection of these massive genomic rearrangements by classical ...
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Proteomics and uterine leiomyomas: a narrative review for better understanding of the disease
... Uterine Leiomyomas (also known as fibroids) are the monoclonal tumors originating from the smooth muscle cells of the myometrium and are generally benign in nature (Linder and Gartler, ...abnormal ...
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Differential Expression of Receptor Tyrosine Kinases (RTKs) and IGF-I Pathway Activation in Human Uterine Leiomyomas
... Uterine leiomyomas (fibroids) are benign tumors that are prevalent in women of reproductive ...in leiomyomas compared with myometrial ...the leiomyomas, and included the IGF-I/IGF-IR, ...
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Estradiol dependent uterine leiomyomas in transgenic mice
... the uterine leiomyomas developed only after puberty in females suggested that they were hormone responsive, probably via this estradiol responsive ...and uterine tumor devel- opment was monitored. No ...
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Utility of a minimal skin incision laparotomy technique for removing uterine leiomyomas at a regional core hospital: a retrospective study
... the leiomyomas were detected. The surface of the uterine trunk was cut with a monopolar electric scal- pel, and a part of the leiomyoma was grasped with a ...
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A Case of Reed Syndrome with a Novel Mutation in the Fumarate Hydratase Gene
... multiple uterine leiomyomas for which she underwent a total abdominal hysterectomy (TAH) that revealed a uterine smooth muscle tumor of uncertain malignant potential ...
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Clinicopathological study of leiomyomas in hysterectomy specimens
... Hysterectomy is a commonly performed procedure in the management of uterine leiomyomas. The ultimate diagnosis and prognosis depends on the histopathological examination; therefore, every operated specimen ...
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The Value of Ultrasonography in the Diagnosis of Leiomyomas in Southeast Nigeria
... Leiomyomas have been shown to increase in size during pregnancy likely due to pregnancy-related increase in estrogens (Baltarowith et al., 1988). However, according to Quyang (Quyang et al., 2006), the current ...
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Case Report Incidental finding of pre-peritoneal leiomyoma during laparoscopic hysterectomy: a case report and literature review
... rather the abdominal wall musculature (Figure 1C). The gynecologist then perform- ed the LH and removed both the uterus and pre-peritoneal ma-ss (Figure 1D) through the vagina. Histological examina- tion of the pelvic ...
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Med12 gain of function mutation causes leiomyomas and genomic instability
... MED12 is located on the X chromosome and encodes a 250- kDa protein that is a subunit of the large mediator complex and is involved in transcriptional regulation of the RNA polymerase II complex. The MED12 protein is ...
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Correlational Analysis of Interleukin 6, Adiponectin and Lipid Indices in Women with Uterine Fibroids
... Furthermore, the progressive adipocyte hypertrophy accentuates low grade chronic inflammation which is thought to play a major role in the progression of uterine fibroids. Adipocytes secrete proinflammatory ...
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Leiomyoma with KAT6B-KANSL1 fusion: case report of a rapidly enlarging uterine mass in a postmenopausal woman
... Monocytic leukemia zinc finger protein-related fac- tor (MORF) located at 10q22, now known as KAT6B, is involved in histone acetyltransferase and allows segments of DNA to be more accessible to transcrip- tion factors. ...
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Dermoscopy as an adjuvant tool for detecting skin leiomyomas in patient with uterine fibroids and cerebral cavernomas
... Cutaneous leiomyomas - accounting for 75% of all extra-uterine leiomyomas - are uncommon benign smooth muscle tumours deriving ei- ther from the erector pili muscle of the pilosebaceous unit ...
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Unexpected pulmonary tumor: metastasis from a benign uterine leiomyoma in a post menopausal woman: a case report
... benign leiomyomas constitute a very rare phenomenon consisting of the occurrence of smooth muscle tumors with similar phenotype and genotype to those of benign uterine leiomyomas [1, ...for ...
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Novel missense mutation in the FH gene in familial renal cell cancer patients lacking cutaneous leiomyomas
... symptomatic uterine leiomyomas before age 40, 2) type 2 papillary renal cell carcinoma before age 40, and 3) a first- degree family member who meets one of the above- mentioned ...cutaneous ...
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Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia
... All MED12 mutations observed in exome or whole genome sequencing studies on CLL have resided in exons 1 and 2. Even though some mutations in other exons might be detectable by targeted sequencing with higher depth of ...
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