v-Abl
The Extreme Carboxyl Terminus of v-Abl Is Required for Lymphoid Cell Transformation by Abelson Virus
... Ras assay. Levels of Ras-GTP were assessed by using the method of de Rooij and Bos (9) in which Ras-GTP is recovered through its interaction with a glutathione S-transferase (GST) fusion protein containing the Ras ...
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Mutations Affecting the MA Portion of the v-Abl Protein Reveal a Conserved Role of Gag in Abelson Murine Leukemia Virus (MLV) and Moloney MLV
... affect v-Abl protein expression and tyrosine kinase ...expressed v-Abl proteins ...the v-Abl proteins, except the kinase-inac- tive D484N mutant (20), had intact tyrosine kinase ...
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Gag Influences Transformation by Abelson Murine Leukemia Virus and Suppresses Nuclear Localization of the v-Abl Protein
... 1. v-Abl proteins encoded by the wild-type virus and gag mu- ...P120 v-Abl protein are depicted. (A) The Gag domains of the mutant v-Abl proteins are expanded to show the amino ...
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The Carboxyl Terminus of v-Abl Protein Can Augment SH2 Domain Function
... the v-Abl tyrosine ...the v-Src SH2 domain to substitute for that of v-Abl in the full-length P120 v-Abl protein and in P70 v-Abl, a protein that lacks the ...
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Ras complements the carboxyl terminus of v-Abl protein in lymphoid transformation.
... expressing v-Abl proteins lacking the carboxyl terminus are compromised in the ability to transform lymphoid but not NIH 3T3 ...of v-Ha-ras com- plemented these mutants in primary bone marrow ...
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Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert.
... Genetic analysis of Ab-MuLV v-abl mv-abl has indicated that the protein kinase activity is necessary for transformation of hematopoietic cells and fibroblasts 40, 64; in con- Hardy-Zucke[r] ...
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Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity.
... WITTE'* Department of Microbiology and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90024,1 and Cancer Research Center and Immunology Gradu[r] ...
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Conservation of function of Drosophila melanogaster abl and murine v-abl proteins in transformation of mammalian cells.
... Accordingly, we sought to determine whether i the transforming potential of the Drosophila abl gene can be activated by the same types of lesions shown to activate the transforming poten[r] ...
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Monoclonal antibodies specific for v-abl- and c-abl-encoded molecules.
... 57, 1986 NOTES Panel A Panel B 123123 P210- -P160 anti-pEX-5 sera were able to reprecipitate the 150,000molecular-weight product of the murine c-abl locus panel B, lanes 1 and 2, respect[r] ...
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A membrane-associated, carbohydrate-modified form of the v-abl protein that cannot be phosphorylated in vivo or in vitro.
... In addition to investigating the 72 effects of verapamil on the full human bioequivalent dose of bedaquiline 25 mg/kg, we 73 also used a sub-optimal dose of bedaquiline 12.5 mg/kg daily,[r] ...
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Detection of the v-abl gene product at cell-substratum contact sites in Abelson murine leukemia virus-transformed fibroblasts.
... 547 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Monoclonal antibodies to the p15 and p12 gag proteins were used to detect the P12ogag-ab transforming protein of Abe[r] ...
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The minimum transforming region of v-abl is the segment encoding protein-tyrosine kinase.
... Insertions of four amino acids, generated by putting synthetic DNA linkers into various restriction enzyme cleavage sites, abolished transforming activity, indicating that much of the in[r] ...
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BCR-ABL and v-abl oncogenes induce distinct patterns of thymic lymphoma involving different lymphocyte subsets.
... tween the BCR-ABL and Oncogenic cooperation MlYC oncogenes be- oncogene expression, and phenotypic heterogeneity in some appearance of both Mo-MuLV and P210 patterns of disease fairly co[r] ...
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Disruption of the Shc/Grb2 Complex during Abelson Virus Transformation Affects Proliferation, but Not Apoptosis
... transfections. v-abl and Shc sequences were expressed using the pMIA vector, a modified form of the pMIG vector (21, 60) that contains v-abl sequences downstream of the internal ribosome entry ...
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ABL: Alignment Based Learning
... The system that simply builds right branch- ing structures results in 82.70 % precision and 92.91 % recall on the ATIS corpus, where ABL got 85.31 % and 89.31 %. This was expected, since English is a right ...
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AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders
... Progress in the understanding of the molecular and cellular mechanisms of human cancer, including human leukemia and lymphomas, has been spurred by cloning of fusion genes created by chromosomal translocations or by ...
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Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons
... to Abl activity [23,47,48], treatment of hippocampal slices with PDGF-BB increased ROCK tyrosine phosphoryla- ...attenuated Abl- induced decreases in NMDA-evoked ...for Abl-medi- ated changes in the ...
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Subcellular localization of Bcr, Abl, and Bcr Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation
... We used specific antisera and immunohistochemical methods to investigate the subcellular localization and expression of Bcr, Abl, and Bcr-Abl proteins in leukemic cell lines and in fresh human leukemic and ...
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Pharmacogenetics and Molecular study on BCR/ABL Inhibitors connected with Chronic Myeloid Leukemia; Genotype variability polymorphism among Babylon population
... After the determination of optimum annealing temperature for BCR-ABL genes by selecting the clearest band which is 62 C°, PCR mixture was 5µl DNA, 5µl master mix, 1.5 forward and reverses primer. PCR conditions ...
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The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila
... of Abl with Fra are intriguing, as they suggest that in Drosophila, as in other organisms, this evolutionarily conserved guidance receptor is regulated by tyrosine phosphorylation, and also that Fra may regulate ...
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