β-amyloid (A β)
Decreased levels of soluble amyloid β protein precursor and β amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus
... as β-amyloid protein (A β 42) have not been assessed at all in this ...CSF-A β 42 levels reflect either increased deposition of this molecule in senile plaques and cerebral blood vessels ...of ...
8
Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... FE65 specifically bind ψXNPXpY (where ψ is a hydropho- bic residue and pY is phosphotyrosine) motifs within receptor tails [73]. APP binding to FE65 is not dependent on phosphorylation, but can be abolished by mutation ...
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β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice
... A β deposition to the ...A β levels [12,13], whereas others have discovered no differ- ence [10,11], with multiple methodological approaches used across ...A β was unchanged with induction of ...
11
Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
... A β : amyloid β peptide; AD: Alzheimer ’ s disease; APH-1: anterior pharynx- defective 1; APP: amyloid β precursor protein; BACE-1: β -site amyloid precursor protein ...
10
Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice
... A β : Amyloid-beta; A β PP swe : Amyloid-beta precursor protein, human Swedish mutation; AD: Alzheimer ’ s disease; C3B6: Mice with a combination C3H/He and C57BL/6 background; CAT: Catalase; ...
21
Cross-talk of membrane lipids and Alzheimer-related proteins
... extracellular β - amyloid plaques and intracellular neurofibrillary tangles in the ...the amyloid β -peptide (A β ), tangles are formed by fibrillar forms of the microtubule associated ...
12
Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... A β levels are mainly determined by the kinetic of SorLA and APP interaction according to the mathematic model which supports the fact that APP sorting pathway is a very im- portant factor in defining the risk of ...
6
APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment
... A β : Amyloid β ; AD: Alzheimer ’ s disease; APLP1: Amyloid-like protein 1; APP: Amyloid precursor protein; CSF: Cerebrospinal fluid; GSM: γ -Secretase modulator; MALDI-TOF/TOF: Matrix-a[r] ...
10
Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab
... 3D6A β 1-40: Fab 3D6 + A β residues 1 – 40; 3D6A β 1-7: Fab 3D6 + A β residues 1 – 7; AAA: amino acid analysis; AD: Alzheimer ’ s disease; APP: amyloid precursor protein; A β : ...
13
Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer’s disease dementia in mild cognitive impairment
... A β : Amyloid beta; A β 40: 40-aminoacid isoform of amyloid beta; A β 42: 42-aminoacid isoform of amyloid beta; BLAD: Bateria de Lisboa para Avaliação de Demência (Lisbon Battery ...
15
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
... AICD: Amyloid intracellular domain; APP: Amyloid precursor protein; A β : Amyloid β ; BACE1: β -secretase; CHO: Chinese hamster ovary cell line; CHX: Cycloheximide – inhibitor of ...
24
Clinical validation of the Lumipulse G cerebrospinal fluid assays for routine diagnosis of Alzheimer’s disease
... positive β-amyloid plaques marker (either reduced Aβ42 or reduced Aβ42/Aβ40 ratio) in combination with a positive marker of fibrillary tau (in- creased p-Tau ...
12
Decreasing the expression of PICALM reduces endocytosis and the activity of β secretase: Implications for Alzheimer's disease
... The amyloid cascade hypothesis is the leading theory to explain the aetiology of AD [6], suggesting that under- standing how the production of β-amyloid (Aβ) from amyloid precursor protein ...
17
Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease
... in β amyloid precursor protein pathways with a general decline in the production of ...between amyloid alterations reflected in the CSF with those in Aβ-PET in a cohort of 199 ...
15
Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer’s disease and transgenic mouse models
... A β 42/40 ratio may be of particu- lar significance as Aβ40 has been found to hinder the aggregation of Aβ42 [24, ...A β 1-40 plays a different role in tau pathogenesis compared to ...
12
Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
... It has been established that CaMKII is dysregulated in AD hippocampus (Fig. 1). We suggest that this dysregu- lation is a key contributor to synaptic degeneration, NFT formation and memory deficits. However, the nature ...
7
Cell adhesion molecules in Alzheimer's disease
... in amyloid-β (Aβ) metabolism, cell plasticity, neuroinflammation, and vascular changes, all of which are considered central to the pathogenesis and progression of Alzheimer’s disease ...
13
Adult hippocampal neurogenesis and its role in Alzheimer's disease
... Alzheimer’s disease (AD), first described by the German neuropathologist Alois Alzheimer as Dementia Praecox in 1907, is an age-related neurodegenerative disease characterized by progressive loss of memory and dete- ...
9
Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent
... Ab concentration is increased in the CP of AD brains, and the expression of the CP A b transporters is altered to decrease A b efflux and/or degradation [39,40]. A b is shuttled bi-directionally across the BCSFB, and the ...
11
RIG-1 receptor expression in the pathology of Alzheimer’s disease
... Alzheimer’s disease (AD) pathogenesis is associated with central nervous system (CNS) inflammatory responses [1-4]. Amyloid-β (Aβ) fibrils trigger inflammatory re- sponses mediated by Toll-like receptors ...
9