β Amyloid precursor protein (APP)
Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... surface APP compared to LRP-null cells, suggesting that the internalization rate of APP is enhanced with LRP ...affect APP endocytosis and ...
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... all APP mutations causative of FAD cluster around the sites of proteolytic processing by the β-secretase and γ-secretase enzymes, releasing the Aβ peptides into the luminal/ extracellular ...Swedish ...
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Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A2 in a spatial-specific manner
... fibrillar amyloid beta (A β ) in the form of amyloid plaques and the development of intraneuronal neurofibrillary tangles consisting of aggregated hyperphosphorylated ...Although amyloid ...
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Association between total-Tau and brain atrophy one year after first-ever stroke
... A β -42: Amyloid- β peptide-42; AD: Alzheimer ’ s disease; ApoE: Apolipoprotein E genotype; APP: Amyloid precursor protein; CSF: Cerebrospinal fluid; IQ- CODE: Informant ...
6
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
... A β generation but not AICD ...total protein extracts from parental and Syt1 KD PC12 cells (n = 4 for PS1 FL, n = 8 for PS1 NTF and PS1 CTF, n = 7 for ...to β actin ...A β 40 and A β 42 ...
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Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review
... E; APP: Amyloid precursor protein; A β plaques: Amyloid- β plaques; BDNF: Brain neurotrophic factor; BFCNs: Basal forebrain cholinergic neurons; cAMP: Cyclic adenosine ...
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EXTRACTION AND IN VITRO SCREENING OF POTENTIAL ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE AND BACE1 INHIBITORS FROM THE LEAVES OF OCIMUM SANCTUMRajbongshi Lata, Rahman Azizur, Rahman Mizanur, Howlader Saurav*DOWNLOAD/VIEW
... (β)- amyloid cascade ...which amyloid precursor protein (APP) is sequentially cleaved by β-site amyloid precursor protein cleaving enzyme 1 (BACE1) ...
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Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
... aggregated amyloid-β (Aβ) peptides [2–4] and hyperphosphorylated tau protein [5–8], ...the amyloid precursor protein (APP) by β- and γ-secretases, can aggregate ...
7
The autophagy related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
... a protein with a key role in autophagy, was decreased in affected brain regions of patients with Alzheimer disease (AD) early in the disease ...human amyloid precursor protein (APP), a ...
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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
... A β : amyloid beta-peptide; AD: Alzheimer ’ s disease; APP: amyloid precursor protein; APPsw: Swedish familial Alzheimer ’ s disease mutant isoform of APP: BACE: ...
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Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... precursor protein (APP) processing [13, 18]. A β levels are mainly determined by the kinetic of SorLA and APP interaction according to the mathematic model which supports the fact that ...
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The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
... the amyloid-β protein (Aβ) was isolated from brains with amyloid depositon and it was subsequently identified as the core protein of neuritic plaques ...from amyloid-β ...
8
CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem
... Similarly, the cognitive composite scores from the 2 cohorts have some differences that should be considered. There are also some intrinsic characteristics of the samples that have to be taken into account: (1) the ...
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Cell adhesion molecules in Alzheimer's disease
... The alteration of the glutamatergic and cholinergic sys- tems are other well-described AD features. The glutamateric aberration, including glutamate excitotoxicity mediated through glutamate receptors such as ...
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RIG-1 receptor expression in the pathology of Alzheimer’s disease
... Alzheimer’s disease (AD) pathogenesis is associated with central nervous system (CNS) inflammatory responses [1-4]. Amyloid-β (Aβ) fibrils trigger inflammatory re- sponses mediated by Toll-like receptors ...
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Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors
... lipid-cholesterol-carrying protein apolipoprotein E (ApoE) are key participants in the pathogenesis of Alzheimer’s disease ...distinct protein sequences, ApoE2, ApoE3, and ...
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Adjusting the compass: new insights into the role of angiogenesis in Alzheimer’s disease
... of amyloid beta (A β ) plaques and ...A β in the cerebral vasculature is closely associated with cognitive decline, and disruption of the blood – brain barrier (BBB) has been shown to coincide with ...
9
Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer’s disease patients
... Analysis of neuropil in the stacks of images of layer II of the TEC revealed that AD patients did not show a sig- nificantly lower synaptic density. However, since we found that TEC thickness in AD patients was 35% thin- ...
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Alzheimer’s in a dish – induced pluripotent stem cell based disease modeling
... of APP in early ...of APP in its close proximity enables BACE-1 to readily cleave an abundance of ...in APP dp neurons but not in fAD neurons carrying the PSEN1ΔE9 mutation [89, ...in APP ...
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Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivomodel of Alzheimer’s disease
... (K670N/M671L) and London (V717I) mutations. These mice feature characteristics of other already published APP Swedish and London mouse models [21,24], but are bred heterozygously on a pure C57BL/6 background at ...
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