β-catenin
PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway
... c-myc, β-Catenin (ProteinTech, Wuhan, China), CK1α, GSK-3β, phosphor- GSK-3β (Ser9), β-TrCP (Abcam, Cambridge, MA, USA); phosphor-β-catenin (Ser45), phosphor-β-catenin ...
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β catenin dependent transcription is central to Bmp mediated formation of venous vessels
... in β -catenin (+) ECs (Table ...of β -catenin in nr2f2 ...that β -catenin plays a role in nr2f2 ...of β -catenin and increased by treatment with BIO (supplementary ...
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Original Article MicroRNA-374a promotes osteogenic differentiation of periodontal ligament stem cells through directly targeting APC/Wnt/β-catenin signaling pathway
... It has been demonstrated that miRNAs modu- late gene expression by binding to target mRNAs, thereby inhibiting their translation. Previous studies reported that miR-374a exhib- ited its functions on the progression of a ...
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Original Article Activation of β-catenin causes defects in embryonic development during maternal-to-zygotic transition in mice
... of β-catenin did not affect preimplantation embryonic develop- ment [13, ...activated β-catenin in mouse embryos, we generated an activated β-catenin assay during embryo ...The ...
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Original Article Expression of E-cadherin, vimentin and β-catenin in ameloblastoma and association with clinicopathological characteristics of ameloblastoma
... use anti-human β-catenin monoclonal antibody in 1% PBS (1:100) at 4°C over night, and then washed in PBS thrice (5 min for each). In neg- ative control, the primary anti- body was replaced with PBS. ...
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Original Article Tubeimoside-1 inhibits the growth and invasion of colorectal cancer cells through the Wnt/β-catenin signaling pathway
... reduced β-catenin expression in CRC ...of β-catenin rescued TBMS1- induced proliferation and invasion inhibition, and knockdown of β-catenin potentiated TBMS1-induced ...
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Original Article Expression of β-catenin and axin in metaplastic breast carcinomas
... of β-catenin in 292 invasive ductal breast ...cytoplasmic β-catenin expression, and high tumor grade, positive Ki67, negative estro- gen receptor ...of β-catenin was associated ...
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IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation
... Western blotting. Western blotting was performed as previously described (7, 18). Briefly, cell or tissue lysate samples, prepared as described above, were resolved on SDS-PAGE. Proteins were then transferred to ...
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RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer
... in β-catenin, LEF1, TCF1 and Wnt10b expression were found in these cells ...Wnt/ β -catenin pathway was activated when RUNX1 was overexpressed and inhibited when RUNX1 was ...
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Simplet/Fam53b is required for Wnt signal transduction by regulating β catenin nuclear localization
... regulates β -catenin nuclear ...of β -catenin in mismatch controls and (D) overexpression of β -catenin in smp ...for β -catenin (red) and staining of nuclei with ...
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The phosphatase Pgam5 antagonizes Wnt/β Catenin signaling in embryonic anterior posterior axis patterning
... Wnt/ β -Catenin signaling (reviewed by Niehrs, ...Wnt/ β - Catenin signaling underlies the Pgam5 morphant ...active β -Catenin as well as increased Dvl2 phosphorylation in Pgam5 ...
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Wnt/β catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse
... and β-catenin conditional mutant ESC lines that were stably transfected with a ubiquitously expressed red fluorescent protein reporter transgene to trace the ESC contribution to chimeric embryos (see ...
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Deubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growth
... Next, we demonstrated that USP9X inhibition retarded the Wnt/β-catenin signal pathway through β-catenin. As transcriptional regulation of c-myc and cyclin D1 may be manifested indirectly by ...
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Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer
... of β-catenin concomitant with nuclear localization of ...with β-catenin, alters the sub-cellular localization of β-catenin, and significantly reduces the protein levels of ...
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miR-96 exerts carcinogenic effect by activating AKT/GSK-3β/β-catenin signaling pathway through targeting inhibition of FOXO1 in hepatocellular carcinoma
... of β-catenin ...degrade β-catenin [31, 32]. β-catenin was the key molecule in this signaling ...of β-catenin was damaged, it would accumulate in the cytoplasm and ...
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Regulation of Wnt/β-catenin signaling by posttranslational modifications
... the β-catenin destruction complex [49,186], it is rea- sonable to expect that sumoylation of Axin is involved in the regulation of Wnt signaling by controlling Axin steady-state ...destabilize ...
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Original Article FAT1 inhibits the proliferation and metastasis of cervical cancer cells by binding β-catenin
... CC metastasis is one of major causes of patient death. It is closely related to EMT, which is char- acterized by the loss of epithelial features and the gain of mesenchymal and migratory fea- tures [5]. Hu et al. showed ...
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Farnesoid X receptor associates with β-catenin and inhibits its activity in hepatocellular carcinoma
... of β-catenin in the cytoplasm and then translocation into the nucleus, where it binds to TCF/LEF transcription factors and then forms a transcriptionally active complex with CBP, Bcl9, and Pygo proteins, to ...
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Activation of Wnt/β-catenin signalling promotes mesenchymal stem cells to repair injured alveolar epithelium induced by lipopolysaccharide in mice
... administered MSCs to migrate and home to inflamed, traumatised, ischaemic, and tumourous tissues [21-25] and their ability to specifically colonise the injured site, rather than intact loci [26]. Likewise, several ...
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Original Article Expression of miR-9 and Wnt/β-catenin in Uyghur and Han patients with high-grade gliomas in Xinjiang
... and β-catenin were overexpressed in high-grade ...and β-catenin expression in high-grade glio- ...and β-catenin was associated with poor prognosis in ...and β-ca- tenin ...
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