β-Catenin/TCF
Roles of β-catenin, TCF-4, and survivin in nasopharyngeal carcinoma: correlation with clinicopathological features and prognostic significance
... of β‑catenin, TCF‑4, and ...of β‑catenin, TCF‑4, and ...of β‑catenin, TCF‑4, and survivin was higher in NPC tissues than in CNP ...amongst ...
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Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10
... attenuate TCF transcriptional activity [12, 20, 31–33], which is particularly significant for its antineoplastic activity given that stabilized β-catenin is associated with colorectal ...reduced ...
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Aberrant nuclear localization of EBP50 promotes colorectal carcinogenesis in xenotransplanted mice by modulating TCF 1 and β catenin interactions
... EBP50 knockdown blocks cell cycle progression and inhibits cell prolifera- tion. (A) Western blot analysis for EBP50, β-catenin, TCF-1, and α-tubulin in mock transfectant and two independent SW480 ...
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Inhibition of β-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear β-Catenin/TCF-1 complex: Critical role of STAT-3
... 33]. β-catenin and other components of Wnt signaling have been found to play an important role in human cancers and that aberrant activation of this signaling pathway was observed in pancreatic tumors ...of ...
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Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation
... between β-catenin and TCF and inhibited the expression of β-catenin/TCF target genes (ZEB1, c-Myc and CyclinD1), which played important roles in doxorubicin- induced EMT in HCC ...
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Gastrin is a target of the β catenin/TCF 4 growth signaling pathway in a model of intestinal polyposis
... of β-catenin, preventing formation of β- catenin/T-cell factor-4 (TCF-4) complexes (3, ...The β- catenin/TCF-4 complex is transported into the nucleus where it acts ...
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A combinatorial code of maternal GATA, Ets and β catenin TCF transcription factors specifies and patterns the early ascidian ectoderm
... The permissive nature of GATA signaling is in keeping with the finding that the down regulation of  -catenin leads to the formation of ectopic epidermis in the vegetal territories (Imai et al., 2000). However, ...
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Role of β-Catenin and TCF/LEF Family Members in Transcriptional Activity of HIV in Astrocytes
... between TCF-4 and the HIV LTR. Indirect effects of  -catenin/TCF-4-mediated inhibition of HIV transcription may include impacting transcriptional factors im- portant for HIV ...that TCF-4 ...
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NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells
... ( β -catenin/TCF complex downstream genes) (Figure ...of β -catenin/TCF signaling. Moreover, downregulation of β -catenin rescued the functions of NOP7, such as the ...
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Distinct roles for Xenopus Tcf/Lef genes in mediating specific responses to Wnt/β catenin signalling in mesoderm development
... of Tcf/Lef factors in mesoderm development? The molecular structures of Tcf/Lef factors are highly conserved in the N-terminal  -catenin-binding domain and the DNA- binding HMG box, but are highly ...
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Identification of Novel T Cell Factor 4 (TCF-4) Binding Sites on the HIV Long Terminal Repeat Which Associate with TCF-4, β-Catenin, and SMAR1 To Repress HIV Transcription
... which TCF-4 mediates inhibition of HIV transcription in ...for TCF-4, which associates with  -catenin and the nuclear matrix protein SMAR1 to create a repressive com- plex for HIV ...
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Original Article miR-140-5p inhibits proliferation, invasion, and promote apoptosis of non-small cell lung cancer cells through targeted inhibition of Wnt signaling pathway
... Wnt1, β-catenin, TCF-4, PCNA, E-cadherin, N-cadherin, Bcl-2 and Bax in each group were detected using quantitative real-time PCR (qRT-PCR) and Western ...Wnt1, β-catenin, TCF-4, ...
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Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method
... The TCF/β-catenin level varied by about 1 order within the range examined in Figure 5 (thin solid line with solid ...The TCF/β-catenin complex varied less than ...
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Original Article Expression of β-catenin and axin in metaplastic breast carcinomas
... The β-catenin, Tcf-4 and Axin protein are key molecules in wnt signaling ...of β-catenin, Tcf-4 and Axin proteins were examined in 40 MBC tissues and 43 invasive ductal carcinoma ...
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Aberrant activation of Wnt/β-catenin signaling drives proliferation of bone sarcoma cells
... active β-catenin, increased levels of β-catenin/TCF transcriptional activity, and activated the downstream target genes, which promoted the proliferation and survival of bone sarcoma ...
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miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a
... Wnt/ β -catenin signaling ...expression β -catenin by transactivating miR-34b/c in prostate cancer [22], and FOXO3a can directly bind to β -catenin and compete with T cell factor ...
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Novel naphthoquinone analogs that target Wnt/β Catenin/TCF4 signaling pathway and clonogenic activity of colon carcinoma cells
... by β- ...Wnt/β- catenin/TCF ...potent β-catenin/TCF inhibitor, BC21 (C 21 H 14 ClN 3 O 4 S), which contains both naphthoquinoneand ...
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Maternal β catenin and E cadherin in mouse development
... E-cadherin, TCF/LEF, APC and AXIN are partially removed, but in the cases cited above the WNT/β-catenin signaling pathway is ...truncated β-catenin undergo normal maturation, ...
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PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway
... of β-catenin at its N-terminal Ser/ Thr residues by CK1 and GSK3β ...Phosphorylated β-catenin is ubiquitinated and undergoes proteasomal ...in β-catenin stabilization and ...
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Function of Wnt/β catenin in counteracting Tcf3 repression through the Tcf3–β catenin interaction
... the Tcf/Lef circuit model in ...cancer, Tcf/Lef–-catenin appears to stimulate the expression of endogenous NTcf1 and full-length Lef1 isoforms, which provide feedback on ...
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