β-Lapachone
The conundrum of α and β lapachone isomerization in acidic media : insights from experimental and implicit/explicit solvation approaches
... In summary, through a combination of experimental and computational approaches, for the first time we are able to rationalize the acid-catalyzed regioselective formation of α- and β-lapachones from lapachol. On ...
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β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia
... b]pyran-5,6-dione; β-LAP) is a natural compound which was originally isolated from the bark of the South American lapacho tree ( Tabebuia avellanedae ) ...[7]. β-LAP has been reported to have a wide variety ...
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Potential mechanism of phytochemical-induced apoptosis in human prostate adenocarcinoma cells: Therapeutic synergy in genistein and β-lapachone combination treatment
... of β-lapachone-and genistein-induced growth inhibition and apoptosis in human prostate cancer, PC3 cell lines were treated as previously ...concentrations β-lapachone (bLap), genistein (gen), ...
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Release of Mitochondrial Cytochrome C in Both Apoptosis and Necrosis Induced by β-Lapachone in Human Carcinoma Cells
... Conclusions: ,B-lapachone induces either apoptotic or necrotic cell death in a variety of human carci- noma cells including ovary, colon, lung, prostate, and breast, suggesting a wide sp[r] ...
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β-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryos
... b- lapachone (n = 318 and 627) alone or together with either 5 μM dicoumarol (n = 215) or 50 μM BAPTA- AM (n = 557) for 4 h and fixed them at 48 ...b- lapachone-treated 48-hpf embryos, a linear arrangement ...
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3 Bromo β lapachone
... As part of a search for compounds with therapeutic activity against a number of parasitic diseases endemic to Brazil, a series of derivatives has been prepared from lapachol Cruz et al.,[r] ...
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Potent Induction of Apoptosis by β-Lapachone in Human Multiple Myeloma Cell Lines and Patient Cells
... tion by triggering typical apoptosis in human multiple myeloma (MM) cells including drug- sensitive cells and freshly derived MM cell from patients, but not of normal peripheral blood mononuclear cells (PBMCs). Impor- ...
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β-Lapachone Induces Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells
... In summary, our studies demonstrated that P3-lapachone induced cell cycle arrest and apo- ptosis in human colon cancer cells SW480, SW620, and DLDl with mutant or defective p53. Various [r] ...
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<p>Ultrasound Combined with Core Cross-Linked Nanosystem for Enhancing Penetration of Doxorubicin Prodrug/Beta-Lapachone into Tumors</p>
... and β -Lapachone (2 mg, ...The β -Lapachone/BDOX- loaded non-cross-linked nanosystem ( β -Lapachone /BDOX-NCS) was ...of β -Lapachone/BDOX-NCS was irradiated using ...
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Cytotoxicity Activity of Semisynthetic Naphthoquinone 1 oximes against Cancer Cell Lines
... The cancer is among the most important diseases of our time, being the second leading cause of death in developed countries. The development of more effective chemotherapeutic drugs is one of the challenges of medicinal ...
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Haplotype Analysis of β-Thalassaemia Major and Carriers with Filipino β-Deletion in Sabah, Malaysia
... 219 β-thalassaemia major (β-TM) patients with homozygous Filipino β°-deletion and 157 carriers with heterozygous Filipino β°-deletion from 10 government hospitals in different regions of ...
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Non-contiguous finished genome sequence and description of Kallipyga massiliensis gen. nov., sp. nov., a new member of the family Clostridiales Incertae Sedis XI
... Kallipyga (cal.li.pi’ga N.L. fem. N. Kallipyga of the Greek epithet kallipygos , said of a statue of Aphro- dite having beautifully proportioned buttocks). Gram-positive cocci. Strictly anaerobic. Mesophilic. Non-Motile. ...
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Dysregulation of the (immuno)proteasome pathway in malformations of cortical development
... the β 1i subunit in the nuclear-enriched frac- tion has also been detected in its catalytically active form [40], and several studies indicate a possible functional role of the immunoproteasome in transcriptional ...
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Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation
... The authors are grateful for G. Thinakaran (The University of Chicago), T. Golde (University of Florida), B. De Strooper (VIB Leuven), Y. Li (Sloan- Kettering Cancer Center), and T. Kitamura (The University of Tokyo), S. ...
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TGF-β inhibits IL-1β-activated PAR-2 expression through multiple pathways in human primary synovial cells
... To investigate the mechanism how Transforming growth factor-β(TGF-β) represses Interleukin-1β (IL-1β)-induced Proteinase-Activated Receptor-2 (PAR-2) expression in human primary synovial cells (hPSCs). ...
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Impact of beta2-agonists, beta-blockers, and their combination on cardiac function in elderly male patients with chronic obstructive pulmonary disease
... of β 2 -agonists, β -blockers, or a combination of both, and indices of cardiac function (NT pro-BNP and ...entered β -blocker and β 2 -agonist use and factors associated with NT pro-BNP at a ...
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The search for the gene mutations underlying enterotoxigenic Escherichia coli F4ab/ac susceptibility in pigs: a review
... unclear. A decade later, two brush border glycoproteins, with a weight of 210 and 240 kDa, were found as poten- tial receptors for F4ac [14]. The F4ac fimbriae bind spe- cifically to both cell surface glycoproteins. ...
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Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent
... A β : amyloid-beta peptide; A β 40: 40 amino acid A β ; A β 42: 42 amino acid A β ; AD: Alzheimer ’ s disease; ANOVA: analysis of variance; BBB: blood-brain barrier; BCSFB: blood-CSF bar[r] ...
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Immune effects of Alarelin on ovarian development and GnRH receptor mRNA expression levels of pituitary in tilapia (Oreochromis niloticus)
... GnRH-a, which indicates that LH can be induced by exogenous GnRH (Mylonas et a1., 1997). An analysis of the genes that express LH-β and FSH-β during the development of the gonad in the male striped bass ...
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Non contiguous-finished genome sequence and description of Peptoniphilus obesi sp. nov.
... α-fucosidase, β-galactosidase, glutamic acid de- carboxylase, 6-phospho-β-galactosidase β- glucosidase, β-glucuronidase, N-acetyl-β- glucosaminidase, D-mannose, D-raffinose, alkaline ...
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