β1 integrins
β1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance
... that β1 integrins regulate neural stem cell behaviour within the CNS niche leads us to question the nature of the ligands recognised by these ...four β1 integrins, α1β1, α3β1, α6β1 and ...of ...
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β1 integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer
... [18]. Integrins are pre- dominantly expressed in the basal cell layer of the mammary epithelium in comparison with the luminal ...ligands, β1-integrins play a critical role in the main- tenance of ...
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β1 integrins are required for normal CNS myelination and promote AKT dependent myelin outgrowth
... To define the functions of β 1 integrins in CNS myelination, we inactivated β 1 expression by crossing mice carrying a floxed integrin β 1 gene (Itgb1-flox) with nestin-Cre mice. In this nestin-Cre line, ...
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Non redundant function of dystroglycan and β1 integrins in radial sorting of axons
... 1 integrins, namely PI-3K and Akt, Rac1, RhoA and RhoE, Fyn, and p38 MAPK (this paper) (Nodari et ...1 integrins, probably activate Fak, Ilk, Src and Rac1 at multiple steps, including early extension of ...
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Endothelial β1 integrins regulate sprouting and network formation during vascular development
... b1 integrins inhibited endothelial cell maturation, migration and sprouting, which resulted in defective vascular network ...b1 integrins induced endothelial cell proliferation and apoptosis via PI3K/AKT ...
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β1 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells
... 1 integrins are required to overcome the tenascin-C-mediated inhibition of migration within the caecum and proximal hindgut and to enhance fibronectin-dependent migration in these ...
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Lack of β1 integrins in enteric neural crest cells leads to a Hirschsprung like phenotype
... as integrins activate the pro-survival PI3 kinase and MAP kinase pathways (Stupack and Cheresh, ...1 integrins in ENCCs does not affect their survival and proliferation during the gut ...1 integrins ...
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New mechanistic insights of integrin β1 in breast cancer bone colonization
... reduced β1 expression adopted a more rounded morphology on the ...targeting β1 integrin expression when they were cultured on basement membrane extract and collagen type I ...a β1 integrin ...
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Conditional β1 integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system
... that β1-integrins are required for the interactions of SC with axons or basal lamina and to facilitate the entry of axons into the muscle layers and the targeting of AChR ...
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Integrins are not essential for entry of coxsackievirus A9 into SW480 human colon adenocarcinoma cells
... RGD-binding integrins include five members of αV integrins (αVβ1, αVβ3, αVβ5, αVβ6 and αVβ8), two β1 integrins (α5β1 and α8β1) and the integrin αIIbβ3, and share the ability to recognize ...
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β1 integrin is a crucial regulator of pancreatic β cell expansion
... whereas integrins αvβ3, αvβ5 and α6β4 regulate cell attachment to specific ECMs and the migration of undifferentiated pancreatic epithelial cells from ductal compartments (Cirulli et ...2003), β1 integrin ...
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Integrins and their ligands in rheumatoid arthritis
... Heterodimers containing αν are another family of fi bronectin-binding integrins. A polymorphism in the gene coding for integrin αν is associated with RA in the European Caucasian population [38]. Th e integrin ανβ3 ...
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Molecular imaging of integrins in oncology
... While integrins expressed on endothelial cells are responsible for the regulation of cell motility and survival, those integrins on carcinoma cells increase the metastatic potential of the tumor by ...
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Endosomal integrin signals for survival.
... the contribution of ‘classic’ focal adhesion signalling versus integrin endosomal signalling, and which integrin-containing signalling platforms are specifically assembled on endosomes? Lastly, we feel that it will be ...
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Integrins in invasive growth
... mid- to late G1, allowing cell cycle progression. The molecular mechanisms by which integrin and growth factor receptor signaling pathways synergize to influence Erk activation are not yet clear, and several possible ...
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Human cytomegalovirus promotes the activation of TGF-β1 in human umbilical vein endothelial cells by MMP-2 after endothelial mesenchymal transition
... A logarithmic increase in the number of progeny viruses was observed in the supernatants and HELF cells, which indicated that HELF supports the proliferative infection HCMV TR (Fig. 1A). Human umbilical vein endothelial ...
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TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5
... (ALK5), is commonly used to block SMAD2/3 phospho- rylation induced by TGF-β1 [28-31]. To examine whether the TGF-β1 type I receptor mediates the inhibitory effects of TGF-β1 on Aβ-induced microglial ...
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PGE2 Generation in Myocardium from Isolated Rat Atrium under Hypoxia and Reoxygenation Conditions Effect of Anti β1 IgG from Patients with Chronic Severe Periodontitis
... Influence of β1 adrenoceptor antagonist atenolol and β1 synthetic peptide β1 peptide upon rat atria contractility dF/dt g/s alone or in the presence of pIgG and xamoterol in normoxia, hy[r] ...
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Original Article Integrin β1 overexpression protects nucleus pulposus cells from apoptosis and attenuates intervertebral disc degeneration
... Forty eight-week-old male SD rats were used. L4/5 and L5/6 IVD degeneration model was developed by destroying both dynamic (mus- cles) and static (bony and ligamentous archi- tecture) restraints as previously described ...
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Rapamycin Inhibits Transforming Growth Factor β1 Induced Fibrogenesis in Primary Human Lung Fibroblasts
... In this study, primary human lung fibroblasts were used in- stead of transformed cell lines. To ensure that the inhibition of collagen level was not due to cytotoxicity of rapamycin, primary human lung fibroblasts were ...
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