V3 peptide
Human Immunodeficiency Virus Type 1 Env Trimer Immunization of Macaques and Impact of Priming with Viral Vector or Stabilized Core Protein
... YU2-derived V3 peptide and a scrambled control V3-derived peptide, we found that V3-specific antibodies were responsible for a significant frac- tion (up to 90% in some sera) of the ...
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Factors Determining the Breadth and Potency of Neutralization by V3-Specific Human Monoclonal Antibodies Derived from Subjects Infected with Clade A or Clade B Strains of Human Immunodeficiency Virus Type 1
... bonded V3 domains ...native V3 structures was usually greater than that of MAbs screened with linear V3 peptides, and such MAbs possessed greater functional activities than previ- ously available ...
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The V3-directed immune response in natural human immunodeficiency virus type 1 infection is predominantly directed against a variable, discontinuous epitope presented by the gp120 V3 domain.
... linear V3 loop structures. First, we probed full- length V3 loops expressed as fusion proteins for binding to antibodies present in serum samples from HIV-1-infected in- ...the V3 loop, as the major ...
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Mapping of the CXCR4 Binding Site within Variable Region 3 of the Feline Immunodeficiency Virus Surface Glycoprotein
... the V3 region required for interaction with ...SU V3 in the FIV-CXCR4 interaction. Therefore, the 41-amino-acid V3 loop peptide was assessed for the ability to block SU binding to ...the ...
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Immunotyping of Human Immunodeficiency Virus Type 1 (HIV): an Approach to Immunologic Classification of HIV
... the V3 loops of viruses from group M (clades A through H) and group O were ...Eleven V3 peptides, representing the sequences of MN, SF2, SC, NY/5, RF, WMJ2, CDC4, BRU, SF33, MAL and ELI, were purchased from ...
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Antibodies That Are Cross-Reactive for Human Immunodeficiency Virus Type 1 Clade A and Clade B V3 Domains Are Common in Patient Sera from Cameroon, but Their Neutralization Activity Is Usually Restricted by Epitope Masking
... a V3 loop from a clade B primary isolate virus (JR-CSF) but not from a clade A primary isolate virus ...consensus V3 peptides demonstrated that the majority of the cross-reactive Cameroonian sera contained ...
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Brucella abortus conjugated with a gp120 or V3 loop peptide derived from human immunodeficiency virus (HIV) type 1 induces neutralizing anti-HIV antibodies, and the V3-B. abortus conjugate is effective even after CD4+ T-cell depletion.
... The difference in isotype patterns observed when B. abortus or KLH was used as carriers suggests that these carriers stim- ulate different cytokines in the immunized mice, probably as a consequence of stimulating ...
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Mutations in both gp120 and gp41 Are Responsible for the Broad Neutralization Resistance of Variant Human Immunodeficiency Virus Type 1 MN to Antibodies Directed at V3 and Non-V3 Epitopes
... the V3 neu- tralization determinant and other non-V3 neutralization do- mains with mutations in other regions of the envelope ...the V3 region proximal to the neutralization epitope was found in the ...
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Maternal Binding and Neutralizing IgG Responses Targeting the C-Terminal Region of the V3 Loop Are Predictive of Reduced Peripartum HIV-1 Transmission Risk
... wild-type peptide. We therefore measured the isolated contributions of maternal V3-specific neutralizing responses to tier 1 virus neutralization using sensitive HIV-2/HIV-1 V3 chimeric ...maternal ...
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Replacement of the V3 Region of gp120 with SDF-1 Preserves the Infectivity of T-Cell Line-Tropic Human Immunodeficiency Virus Type 1
... The V3 region of any strain of HIV-1 has a simple loop structure with one disulfide ...cyclized V3 peptides but not the linear or M-tropic V3 peptides could directly bind to CXCR4 and inhibit ...
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MR appearance of trigeminal and hypoglossal motor denervation
... in V3 and hy- poglossal denervation depend on the chronicity of the ...in V3 denervation in the acute stage but was present in subacute V3 denervation and in both acute and subacute hypoglossal ...
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Effect of the V3 Loop Deletion of Envelope Glycoprotein on Cellular Responses and Protection against Challenge with Recombinant Vaccinia Virus Expressing gp160 of Primary Human Immunodeficiency Virus Type 1 Isolates
... the V3 loop induces both humoral and cellular responses against HIV-1 (29), possibly explaining the antigenic variation associated with this ...the V3 loop (22) or using gp160 proteins that lack V3 ...
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An accurate and efficient experimental approach for characterization of the complex oral microbiota
... rRNA V3–V4 hypervariable region [12, ...16S V3–V4 sequencing data obtained for the same ...and V3–V4 regions from a single mock community with known ...
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HmmUFOtu: An HMM and phylogenetic placement based ultra fast taxonomic assignment and OTU picking tool for microbiome amplicon sequencing studies
... V1 V3 datasets), suggesting the consensus of all observed sequences generally better repre- sents the true bacterial target gene sequences by aggregat- ing information across multiple reads and/or ...
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Evolution of the V3 envelope domain in proviral sequences and isolates of human immunodeficiency virus type 1 during transition of the viral biological phenotype.
... It was shown that replacement of the original HXB-2 V3 region by the H168 SI-associated V3 region resulted in a virus that had SI capacity in SupTl cells, whereas replacement with a sequ[r] ...
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The "V3" domain is a determinant of simian immunodeficiency virus cell tropism.
... Replication of SlVmac "V3" mutants in CEMx174 cells, alveolar macrophages, and rhesus PBMC SIVmac239 "V3" loop amino acid sequence ENV* ..... Locations and biological effects of amino ac[r] ...
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High resolution deep sequencing reveals biodiversity, population structure, and persistence of HIV 1 quasispecies within host ecosystems
... rather than the dominant variants, to next generation plasma HIV-1 populations with enhanced fitness. Low- frequency variants expand the fitness landscape for virus populations, while providing an array of evolutionary ...
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A Diagnostic HIV 1 Tropism System Based on Sequence Relatedness
... the V3 region (36), most tests focus today on V3-derived information (19, 37, ...the V3 region of the envelope glycoprotein gp120 of ...the V3 region of known coreceptor tropism is hybridized ...
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V3 loop of the human immunodeficiency virus type 1 Env protein: interpreting sequence variability.
... Four features of the sequence heterogeneity in V3 were observed: i approximately 70%o of all nonconservative basic substitutions occur at four positions in V3, and V3 sequences with a ba[r] ...
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Brucella abortus conjugated with a peptide derived from the V3 loop of human immunodeficiency virus (HIV) type 1 induces HIV-specific cytotoxic T-cell responses in normal and in CD4+ cell-depleted BALB/c mice.
... Effect of anti-L3T4 treatment on the induction of an an- ti-MN V3 CTL response. All of the previously described ex- periments were conducted with immunologically intact BALB/c mice. However, the potential target ...
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