vaccine delivery
In Vivo Electroporation of Minicircle DNA as a Novel Method of Vaccine Delivery To Enhance HIV-1-Specific Immune Responses
... gene delivery system. In vivo electroporation (EP)-based DNA delivery has attracted great attention for its potency to enhance cellular uptake of DNA vaccines and function as an ...gene delivery in ...
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Dual stimulation of antigen presenting cells using carbon nanotube based vaccine delivery system for cancer immunotherapy
... itant delivery of the model antigen OVA and CpG using S /þ to ...a delivery vehicle for an- tigens [7,9] or immunoadjuvants [11,12] in vitro and in ...
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Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector.
... viral vaccine vector, especially against ...HIV vaccine delivery strategy using VEE-based vectors could induce protection against invasion across a mucosal ...
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Route of Adenovirus-Based HIV-1 Vaccine Delivery Impacts the Phenotype and Trafficking of Vaccine-Elicited CD8+ T Lymphocytes
... to immunized or control animals (n ⫽ 4/group). At day 6 following adoptive transfer, proliferation, as assessed by CFSE dilution, was evaluated at multiple anatomic sites. Only mini- mal proliferation of OT-1 lymphocytes ...
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The impact of a human papillomavirus (HPV) vaccination campaign on routine primary health service provision and health workers in Tanzania: a controlled before and after study
... 9-valent vaccine targeting an additional 5 oncogenic HPV genotypes has been licensed in the USA and Europe ...HPV vaccine delivery is recom- mended by the World Health Organization (WHO) for 9– 13 ...
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Engineering T7 bacteriophage as a potential DNA vaccine targeting delivery vector
... caveolae pathway. Although the amount of Tat-phage penetrate into the cells was much higher than the phage without Tat displayed, the gene transfer efficiency medi- ated by Tat peptide was lower than that via ...
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Comparison of polystyrene nanoparticles and UV inactivated antigen displaying adenovirus for vaccine delivery in mice
... vectors, delivery on polystyrene particles does not change the antibody profile compared to protein immunization, which con- sists predominantly of IgG1 subtype ...
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Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A
... recipients of the IRIV formulation seroconverted (> or = 20 mIU/ml) versus 30 and 44% for those who received the fluid and alum-adsorbed vaccines, respectively (P < 0.001). The geometric mean anti-HAV antibody ...
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A Nonproliferating Parvovirus Vaccine Vector Elicits Sustained, Protective Humoral Immunity following a Single Intravenous or Intranasal Inoculation
... ideal vaccine delivery system would elicit persistent protection following a single administration, pref- erably by a noninvasive route, and be safe even in the face of immunosuppression, either inherited ...
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Characterization and optimization of bilosomes for oral vaccine delivery
... the vaccine and comply with 3R protocols, the key correlate of protection, the Median temperature differential, was measured to follow protection against fever and inflammatory cell counts in nasal washes (Fig ...
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Airway Delivery of an Adenovirus-Based Ebola Virus Vaccine Bypasses Existing Immunity to Homologous Adenovirus in Nonhuman Primates
... at day 0. This virus preparation, administered with identical dos- ing and conditions, had been fully lethal in 13 control macaques challenged in our laboratory in the previous 18 months (44). NHP vaccinated i.m. in the ...
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POLIO: A REVIEW
... polio vaccine (OPV) Poliomyelitis has been a notifiable disease in Australia since ...polio vaccine (IPV-Salk) first started in Australia in ...polio vaccine (OPV-Sabin) in the publicly funded ...
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Delivery of Human Immunodeficiency Virus Vaccine Vectors to the Intestine Induces Enhanced Mucosal Cellular Immunity
... p.o. delivery of replication-defective rAd vectors has posed a challenge and has met with variable levels of ...systemic delivery (33), and a much higher dose is required to induce immune responses ...HIV ...
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Metal organic frameworks : from anticancer multifunctional drug delivery systems to novel vaccine adjuvants
... 6 This free radical molecule (it has an unpaired electron in the 2π orbital) can interact with transition metals and an unpaired electron could accept an electron and thus acting as an anti-oxidant 47 . NO is an ...
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From concept to content: assessing the implementation fidelity of a chronic care model for frail, older people who live at home
... care delivery that relieve the pressure on primary care systems whilst upholding quality standards for elderly ...care delivery based on the Chronic Care Model (CCM) ...the delivery of chronic care ...
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Hepatitis B - Its Prevention by Vaccine
... Many different tests are carried out in the course of vaccine production to assure the precise content and composition of surface antigen and the absence of extraneous virus. Testing is conducted in artificial ...
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Current scenario of vaccine development against a neglected disease: visceral leishmaniasis
... Salivary proteins of vector-sandfly also fetch attraction as suitable anti-VL vaccine candidates. They received little attention in spite of the fact that salivary proteins from the vector are also delivered to ...
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The landscape of vaccines in China: history, classification, supply, and price
... acellular vaccine; DTaP-Hib: Diphtheria- tetanus-acellular pertussis combined vaccine and Haemophilus influenza type b conjugate vaccine; DTwP: Diphtheria-tetanus-pertussis whole cell vaccine; ...
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Characterization of a Neuraminidase-Deficient Influenza A Virus as a Potential Gene Delivery Vector and a Live Vaccine
... Intranasal infection of mice with an NA-deficient virus gen- erated protective immunity against lethal influenza virus chal- lenge (Table 2). Although the NA protein is a major surface antigen and can induce protection ...
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Immunoprotective Activity and Safety of a Respiratory Syncytial Virus Vaccine: Mucosal Delivery of Fusion Glycoprotein with a CpG Oligodeoxynucleotide Adjuvant
... candidate vaccine has ad- vanced to clinical trials in immunologically naive infants in 4 ...heat-stable vaccine that could be administered without needles, combined with ongoing difficulties in formulating ...
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